Comfortis for Dogs 60.1-120 lbs

Comfortis Chewable Tablet for Large Dogs (60.1–120 lbs)

Fast-Acting Flea Control

Comfortis for Large Dogs is an oral, beef-flavored chewable tablet formulated to kill and prevent flea infestations on dogs weighing between 60.1 to 120 lbs. This fast-acting flea control medication contains spinosad, a trusted veterinary-approved active ingredient that begins killing fleas within 30 minutes and provides full protection for 30 days. Ideal for households dealing with persistent flea issues, Comfortis offers systemic protection by circulating through your dog’s bloodstream, delivering continuous flea elimination with no mess or greasy residue.

This product is a preferred choice for pet parents who want an easy-to-administer, mess-free solution that doesn’t interfere with topical treatments or bathing routines.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Also Available in Other Comfortis Weight Ranges

Comfortis Chewable Tablets come in multiple weight-specific options to ensure safe and effective flea protection for both dogs and cats. Select the right strength based on your pet’s weight for maximum efficacy:

• Comfortis Chewable Tablet for Dogs 5–10 lbs / Cats 4.1–6 lbs – Ideal for small dogs and petite cats.
• Comfortis Chewable Tablet for Dogs 10.1–20 lbs / Cats 6.1–12 lbs – Designed for small to mid-sized dogs and growing cats.
• Comfortis Chewable Tablet for Dogs 20.1–40 lbs / Cats 12.1–24 lbs – Suitable for medium-sized dogs and larger cats.
• Comfortis Chewable Tablet for Dogs 40.1–60 lbs – Perfect for large breed dogs needing reliable monthly flea protection.
• Comfortis Chewable Tablet for Dogs 60.1–120 lbs – Specially formulated for extra-large dogs to ensure full-body flea defense. (you are viewing this product)

Pro Tip: For best results, match the product to your pet’s exact weight range and administer monthly. Always consult your veterinarian if you're unsure which variant is right for your pet.

What Are the Benefits of Comfortis Chewable Tablets for Dogs 60.1–120 lbs?

Comfortis stands out in the flea treatment category with several advanced features not found in many topical treatments:

• Fast onset of action – starts killing fleas in 30 minutes
• Full month protection – one tablet provides 30 days of flea prevention
• Highly palatable beef-flavored chewable – easy to administer
• Kills fleas before they can lay eggs – breaks the flea life cycle effectively
• No residue or odor – great for households with children or other pets
• Safe for multi-pet households – doesn’t affect other pets via contact
• Vet-recommended alternative to topical flea treatments

How to Administer Comfortis for Large Dogs?

Always consult your veterinarian for exact dosage instructions depending on your pet's condition. As a general guideline:

• Give orally once a month
• Administer with food for optimal absorption
• Ensure your dog consumes the full dose
• Use year-round to maintain consistent protection

Tips for Pet Parents Using Comfortis for the First Time

If you're new to oral flea treatments, here are some vet-approved tips:

• Give with a full meal – Helps absorption and reduces nausea
• Use a pill pocket or wrap in soft food if your dog is fussy
• Set a reminder on your phone or calendar for monthly doses
• Monitor your dog for 24 hours after the first dose for any mild side effects
• Combine with an environmental flea treatment if you have a severe infestation

What Ingredients Are in Comfortis for Dogs?

Comfortis uses a powerful veterinary-grade active compound:

• Active Ingredient: Spinosad (810 mg) – derived from a natural soil bacterium (Saccharopolyspora spinosa), it targets flea nervous systems, causing paralysis and death.
• Inactive Ingredients: Artificial beef flavoring, cellulose, starch, preservatives, and other inert binders.

Note: Spinosad is considered safe for long-term use in dogs over 14 weeks of age.

How Does Comfortis Compare to Other Flea Treatments?

Choosing the right flea protection can be confusing with so many options—topicals, collars, sprays, or tablets. Here’s why Comfortis stands out for large dogs:

💡 Pet parents love the no-mess aspect of Comfortis—it doesn’t interfere with grooming, cuddling, or bathing.

When Should I Start Using Comfortis for My Dog?

Start using Comfortis when:

• You notice your dog scratching more than usual
• Flea dirt or adult fleas are visible on the coat
• You’ve just treated your home/environment for fleas
• Your dog frequents parks, trails, or daycare facilities
• You're switching from a topical and want continuous protection without skin residue

🕒 Pro tip: Start Comfortis before flea season (typically spring) to stay one step ahead of infestations.

Are There Any Side Effects of Comfortis Tablets?

Most dogs tolerate Comfortis well. However, some may experience:

• Vomiting or decreased appetite
• Lethargy or increased salivation
• Diarrhea or trembling

These side effects are usually mild and transient. If symptoms persist or worsen, consult your veterinarian promptly.

What Precautions or Warnings Should I Be Aware Of?

• Only for dogs 14 weeks and older, weighing between 60.1 to 120 lbs
• Do not split tablets; each dose is pre-measured
• Not approved for breeding, pregnant, or lactating females
• Keep out of reach of children and other animals
• Avoid using with ivermectin-based medications unless advised by a vet

Shipping & Returns

Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Comfortis for Large Dogs FAQs 

Is Comfortis safe for dogs with sensitive stomachs?

Some dogs may vomit if Comfortis is taken on an empty stomach. Always administer with food to reduce the risk of gastrointestinal upset.

Does Comfortis kill ticks as well as fleas?

No, Comfortis is only effective against fleas. If you need tick protection, consider using an additional tick preventive product approved by your vet.

Can I give Comfortis to pregnant or lactating dogs?

Comfortis has not been evaluated for use in pregnant or nursing dogs, so it’s best to avoid unless your veterinarian advises otherwise.

How do I know Comfortis is working on my dog?

You may notice a reduction in scratching and the presence of dead fleas in your dog’s bedding or coat within hours. Full flea death occurs within 4 hours post-dose.

Is it okay to bathe my dog after giving Comfortis?

Yes! Since it’s an oral flea treatment, bathing, swimming, or rain exposure will not impact its effectiveness.

Can I crush Comfortis and mix it with food?

Crushing is not recommended, as it may affect the medication’s palatability or absorption. Instead, try hiding the tablet in a pill pocket or soft treat.

Do I still need to treat my home for fleas if my dog is on Comfortis?

Yes. While Comfortis kills adult fleas on your dog, flea eggs, larvae, and pupae in the environment can still mature. Combine Comfortis with environmental control measures for full effectiveness.

How long does it take to eliminate a flea infestation with Comfortis?

Most infestations improve within a few days to weeks, but monthly use for 3 consecutive months is often needed to break the flea life cycle entirely.

Authoritative Resources 

• Spinosad Factsheet – NPIC (Oregon State University)
• Flea Allergy Dermatitis in Pets – VCA Animal Hospitals
• Flea Control Strategies – Merck Veterinary Manual