Butequine (phenylbutazone) Paste for Horses

Effective Musculoskeletal Inflammation Relief for Horses

Product Description

Butequine™ paste is a prescription NSAID formulated to relieve inflammatory conditions affecting the musculoskeletal system in horses using phenylbutazone. It is an easy-to-administer oral paste in a pre-filled syringe with a dosing ring and calibrated markings to help deliver the correct dose based on weight. Use only under veterinary guidance to support improved comfort and mobility.

Benefits

• Inflammation Relief: Provides targeted support for inflammatory conditions in the musculoskeletal system of horses.
• Easy Dosing: Adjustable ring and clear syringe markings make it simple to deliver accurate, weight-based doses.
• Prompt Response: Many horses show clinical improvement within about 24 hours of therapy.
• Veterinarian Recommended: Prescription-only formulation to ensure safe, supervised use in horses requiring anti-inflammatory treatment.

Ingredients

Active Ingredients

Phenylbutazone: 1g per 3 ml

How to Use

Recommended-Dosage Chart

Dosage & Administration Instructions

• Adjust Ring First: Move the dosing ring to correct the gram marking before administration to prevent overdosing.
• Empty Oral Cavity: Ensure the horse’s mouth is empty before placing paste on the back of the tongue.
• Initial Higher Dose: Use a relatively higher dose during the first 48 hours without exceeding four grams daily.
• Reduce Gradually: Gradually reduce to the lowest effective maintenance dose producing the desired clinical response.
• Evaluate After Five Days: Reevaluate the diagnosis if no significant clinical improvement is observed after five days.
• Veterinary Prescription Required: Federal law restricts this medication to licensed veterinarian supervision and authorization.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Keep Track of Blood Counts: Start with weekly blood counts and then move to every two weeks as therapy progresses.
• Stop at the First Signs: If any gastrointestinal upset or jaundice shows up, discontinue the medication right away.
• Use With Caution: Be careful when administering this to horses with a known history of drug allergies.
• Handle Infections Separately: Make sure to provide specific anti-infective treatment when inflammation is linked to an infection.
• Not for Human Consumption: Do not use this medication in horses that are meant for human consumption.

Possible Side Effects

• Gastrointestinal Disturbances: This may cause digestive irritation, which requires stopping treatment right away and getting a veterinary evaluation.
• White Cell Reduction: There may be significant decreases in total white blood cell counts during treatment.
• Tarry Stools Warning: If you notice black or tarry stools, you need to stop the medication immediately and take the necessary steps to address it.
• Agranulocytosis Risk: This is a rare but serious blood disorder reported in humans and in long-term canine treatment.

Storage Information

• Controlled Room Temperature: Store at temperatures between 15°C and 25°C to maintain stability.
• Keep Securely Stored: Keep out of reach of children and other animals to prevent accidental exposure.

Frequently Asked Questions

Q1: What is Butequine paste used for in horses?

Ans: Butequine paste helps relieve inflammatory conditions in the musculoskeletal system of horses. It contains phenylbutazone, a non-hormonal anti-inflammatory that also lowers fever and improves comfort by reducing inflammation.

Q2: How much Butequine paste should I give my horse?

Ans: The recommended dosage is 1-2 grams of phenylbutazone per 500 lbs of body weight daily, not exceeding 4 grams per day. A relatively higher dose may be used during the first 48 hours before reducing to the lowest effective maintenance dose.

Q3: How quickly does Butequine paste start working?

Ans: Response to Butequine paste therapy is generally prompt, with clinical improvement usually occurring within 24 hours. If no significant response is observed after five days of treatment, the diagnosis and therapeutic approach should be reevaluated by a veterinarian.

Q4: Is Butequine paste safe for all horses?

Ans: Butequine paste should be used cautiously in horses with a history of drug allergies and must not be used in horses intended for human consumption. It is restricted to use by or on the order of a licensed veterinarian.

Q5: What monitoring is required during Butequine therapy?

Ans: Routine blood counts are recommended weekly during the early phase of therapy and every two weeks thereafter. Any significant drop in white blood cell counts or signs such as black or tarry stools requires immediate discontinuation and veterinary evaluation.

Clinical Research:

https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=ac2448b6-b7e9-47fe-9b32-0b96c7b14672
https://www.federalregister.gov/documents/2003/07/25/03-18910/oral-dosage-form-new-animal-drugs-phenylbutazone-paste

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/1025