{"product_id":"numelvi-atinvicitinib-tablets-for-dogs","title":"Numelvi (atinvicitinib tablets) for Dogs","description":"\u003cp align=\"center\"\u003e\u003cimg width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/hardypaw.com\/cdn\/shop\/files\/rx-map.webp\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003c\/p\u003e\n\u003ch2\u003eOnce-Daily Itch Relief Tablet for Dogs with Allergic Dermatitis\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eNumelvi (atinvicitinib tablets) is a vet-prescribed oral medication that helps dogs get on top of the itch that comes with allergic dermatitis. It gets to work quickly, bringing noticeable relief in as little as 2 to 4 hours. Given once daily with food around mealtime, dogs and puppies that have crossed the 6-month mark can safely be put on this treatment. Sourced directly from the manufacturer or an approved distributor, every pack is guaranteed authentic.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eActs Fast:\u003c\/strong\u003e Gets absorbed quickly, with allergic itch starting to ease within 2 to 4 hours based on a canine itch model.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSuitable for Young Dogs:\u003c\/strong\u003e Dogs and puppies that have crossed the 6-month mark can safely be started on this treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEasy, Once-Daily Dosing:\u003c\/strong\u003e Just one daily dose given with food around mealtime keeps allergic itch under consistent, straightforward control.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo Interference with Routine Treatments:\u003c\/strong\u003e Works well alongside routine treatments and vaccines, with no meaningful drug interactions flagged during field trials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHighly Selective for JAK1:\u003c\/strong\u003e At least 10 times more selective for JAK1 over JAK2, JAK3, and TYK2 in laboratory assays.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePreserves Immune Function:\u003c\/strong\u003e High JAK1 selectivity minimises interference with the beneficial immune roles of other JAK enzymes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSupports Vaccine Response:\u003c\/strong\u003e Dogs on Numelvi demonstrated an adequate immune response to standard canine vaccinations in studies.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eVariants\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e4.8 mg tablets\u003c\/li\u003e\n\u003cli\u003e7.2 mg tablets\u003c\/li\u003e\n\u003cli\u003e21.6 mg tablets\u003c\/li\u003e\n\u003cli\u003e31.6 mg tablets\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eActive Ingredients\u003c\/h4\u003e\n\u003cp\u003eAtinvicitinib\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDosage \u0026amp; Administration Instructions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e Numelvi is a prescription-only medication and must be used only under the direction of a licensed veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnce-Daily Oral Dose:\u003c\/strong\u003e Administer orally once daily at 0.36 to 0.54 mg\/lb (0.8 to 1.2 mg\/kg) body weight as per the dosing table.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGive With Food:\u003c\/strong\u003e Always administer Numelvi with food at or around mealtime to ensure proper absorption and reduce stomach upset.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTablet Size by Weight:\u003c\/strong\u003e Use the tablet strength that matches your dog's body weight as directed in the veterinarian-provided dosing chart.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eScored Tablets:\u003c\/strong\u003e Each tablet is scored and can be split in half when half-tablet dosing is required for your dog's weight.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInform Your Vet:\u003c\/strong\u003e Always tell your veterinarian about all other medicines and supplements your dog is currently receiving before starting Numelvi.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot for Young Puppies:\u003c\/strong\u003e Numelvi should not be used in dogs younger than 6 months of age under any circumstances.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid in Serious Infections:\u003c\/strong\u003e Do not administer Numelvi to dogs that are currently suffering from serious active infections.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eIncreased Infection Risk:\u003c\/strong\u003e Numelvi may increase susceptibility to opportunistic infections, including demodicosis and interdigital furunculosis; monitor your dog closely during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHistory of Demodicosis:\u003c\/strong\u003e Weigh the risks and benefits carefully before starting treatment in dogs with a history of recurrent demodicosis.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eJAK Inhibitor — Risk of New Growths:\u003c\/strong\u003e Numelvi is a JAK inhibitor; new benign and malignant neoplastic conditions have been reported in dogs treated with other JAK inhibitors; discuss this risk with your veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLimited Field Study Duration:\u003c\/strong\u003e Numelvi's effectiveness and safety beyond 28 days remain unstudied, so loop in your vet for any long-term use decisions.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreeding, Pregnant, or Lactating Dogs:\u003c\/strong\u003e How Numelvi affects breeding, pregnant, or nursing dogs has not yet been looked into.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImmunosuppressive Combinations:\u003c\/strong\u003e Pairing Numelvi with glucocorticoids, cyclosporine, or other immunosuppressive agents has not been studied for safety.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eVomiting or Nausea:\u003c\/strong\u003e Observed in some dogs during clinical studies; monitor your dog after each dose if this occurs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Upset:\u003c\/strong\u003e Flatulence, retching, bloating, anorexia, and diarrhea were among the gastrointestinal effects reported in the field study.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEar Infections:\u003c\/strong\u003e Otitis externa was noted in a small number of dogs treated with Numelvi during clinical trials.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eUrinary Changes:\u003c\/strong\u003e Hematuria, crystalluria, increased urination, and urinary tract infections were reported in some treated dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlood Work Changes:\u003c\/strong\u003e Some dogs showed abnormal results including leukopenia, neutropenia, and elevated liver enzymes such as ALT and AST.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological Signs:\u003c\/strong\u003e Tremors and ataxia were observed in a small number of dogs; consult your vet immediately if these signs appear.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage:\u003c\/strong\u003e Store Numelvi tablets at 15 to 30°C (59 to 86°F) to maintain product integrity and effectiveness.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep Away from Pets:\u003c\/strong\u003e Always store in a secure, closed location well out of reach of dogs and other household animals.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep Away from Children:\u003c\/strong\u003e This is a prescription veterinary drug; store it safely away from children at all times.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/en-ca\/pages\/shipping-policy\" target=\"_blank\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ca\/policies\/refund-policy\" target=\"_blank\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What is Numelvi used for in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Numelvi (atinvicitinib tablets) is a prescription oral tablet used to control itching caused by allergic dermatitis, including atopic dermatitis, in dogs six months of age and older weighing at least 2 kg.\u003c\/p\u003e\n\u003ch3\u003eQ2: How does this atinvicitinib itch tablet work for dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Numelvi works by selectively blocking JAK1, the main enzyme responsible for triggering itch and inflammation in allergic skin conditions. Its high selectivity helps preserve the dog's broader immune function while reducing pruritus.\u003c\/p\u003e\n\u003ch3\u003eQ3: How quickly does Numelvi start working in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Numelvi starts relieving allergic itch within 2 to 4 hours after dosing, based on a canine interleukin-31-induced pruritus model study. Results in individual dogs may vary; always follow your veterinarian's guidance.\u003c\/p\u003e\n\u003ch3\u003eQ4: How often should I give my dog the Numelvi itch relief tablet?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Numelvi is administered once daily by mouth with food at or around mealtime. The correct tablet strength and dose are determined by your dog's body weight, and your veterinarian will provide a personalised dosing chart for your pet.\u003c\/p\u003e\n\u003ch3\u003eQ5: What sizes does the Numelvi dog allergy tablet come in?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Numelvi is available in four scored tablet strengths: 4.8 mg, 7.2 mg, 21.6 mg, and 31.6 mg. Each strength is marked with S, M, L, or XL and is available in 30 or 90 count bottles.\u003c\/p\u003e\n\u003ch2\u003eReferences\u003c\/h2\u003e\n\u003cp\u003eBased on a canine interleukin-31 (cIL-31) itch model, no meaningful drug interactions were picked up during a 28-day field trial in dogs with allergic dermatitis. This covered use alongside antimicrobials including topicals, ecto- and endoparasiticides such as isoxazolines, milbemycins, avermectins, pyrethrins, and pyrethroids, as well as analgesics, anesthetics, nutritional supplements, non-glucocorticoid topical skin and ear cleansers, and medicated shampoos.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/doi.org\/10.1111\/vde.70046\" target=\"_blank\" rel=\"noopener\" title=\"1. Kowalski t, prohaczik a, locke k, et al. The second-generation janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet dermatol. 2026;0:17-18. Https:\/\/doi.org\/10.1111\/vde.70046\" aria-label=\"Visit a webpage about 1. Kowalski t, prohaczik a, locke k, et al. The second-generation janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet dermatol. 2026;0:17-18. Https:\/\/doi.org\/10.1111\/vde.70046\"\u003e1. Kowalski T, Prohaczik A, Locke K, et al. The second-generation Janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet Dermatol. 2026;0:17-18. https:\/\/doi.org\/10.1111\/vde.70046\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e2. Data on File. Study Summary REF-11196. Merck Animal Health\u003c\/p\u003e","brand":"Merck Animal Health","offers":[{"title":"4.8-mg \/ 30 Tablets","offer_id":46334339121313,"sku":"217935","price":112.0,"currency_code":"CAD","in_stock":true},{"title":"4.8-mg \/ 60 tablets","offer_id":46334339154081,"sku":"217935-2","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"4.8-mg \/ 90 tablets","offer_id":46334339186849,"sku":"217942","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"7.2-mg \/ 30 Tablets","offer_id":46334339219617,"sku":"218073","price":112.0,"currency_code":"CAD","in_stock":true},{"title":"7.2-mg \/ 60 tablets","offer_id":46334339252385,"sku":"218073-2","price":224.0,"currency_code":"CAD","in_stock":true},{"title":"7.2-mg \/ 90 tablets","offer_id":46334339285153,"sku":"218075","price":336.0,"currency_code":"CAD","in_stock":true},{"title":"21.6-mg \/ 30 Tablets","offer_id":46334339317921,"sku":"218062","price":120.0,"currency_code":"CAD","in_stock":true},{"title":"21.6-mg \/ 60 tablets","offer_id":46334339350689,"sku":"218062-2","price":239.0,"currency_code":"CAD","in_stock":true},{"title":"21.6-mg \/ 90 tablets","offer_id":46334339383457,"sku":"218061","price":358.0,"currency_code":"CAD","in_stock":true},{"title":"31.6-mg \/ 30 Tablets","offer_id":46334339416225,"sku":"218059","price":120.0,"currency_code":"CAD","in_stock":true},{"title":"31.6-mg \/ 60 tablets","offer_id":46334339448993,"sku":"218059-2","price":239.0,"currency_code":"CAD","in_stock":true},{"title":"31.6-mg \/ 90 tablets","offer_id":46334339481761,"sku":"218058","price":358.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/numelvi-atinvicitinib-tablets-for-dogs-pet-medicine-172.png?v=1781205128","url":"https:\/\/hardypaw.com\/en-ca\/products\/numelvi-atinvicitinib-tablets-for-dogs","provider":"HardyPaw","version":"1.0","type":"link"}