{"product_id":"trifexis-flea-worm-chewable-tablets-for-extra-large-dogs-brown-box","title":"Trifexis Chewable Tablets for Dogs 60.1-120 lbs (Spinosad + Milbemycin Oxime)","description":"\u003ch2\u003e5-in-1 Monthly Flea, Heartworm \u0026amp; Intestinal Parasite Protection for Large Dogs (60.1–120 lbs)\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eTrifexis Chewable Tablets (Brown Box) are a prescription, once-monthly oral treatment for dogs and puppies weighing between 60.1 and 120 pounds. Each beef-flavored tablet brings together Spinosad and Milbemycin Oxime to tackle five different parasites in a single monthly dose. It kills fleas fast, keeps heartworm disease at bay, and clears adult hookworm, roundworm, and whipworm infections all at once. Works for puppies that are 8 weeks or beyond in age and have reached at least 5 pounds in weight.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eKills Fleas Fast:\u003c\/strong\u003e Spinosad starts killing fleas within 30 minutes of the tablet being given, reaching full flea kill effectiveness within 4 hours.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrevents Heartworm Disease:\u003c\/strong\u003e Milbemycin Oxime targets the L3 and L4 larval stages of Dirofilaria immitis before they grow into adult heartworms in large dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eControls Flea Infestations:\u003c\/strong\u003e Wipes out existing flea infestations and stops new ones; field studies recorded flea reductions of 98% to 99.8% over three monthly treatments.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Roundworms:\u003c\/strong\u003e Clears adult Toxocara canis and Toxascaris leonina infections with 90% or greater effectiveness against these common intestinal parasites.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Hookworms:\u003c\/strong\u003e Gets rid of adult Ancylostoma caninum infections, a parasite that can cause serious blood loss even in larger, stronger dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Whipworms:\u003c\/strong\u003e Also tackles adult Trichuris vulpis infections, a level of coverage that many heartworm-only products simply do not offer.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLarge Breed Dosing:\u003c\/strong\u003e Formulated specifically for dogs between 60.1 and 120 pounds, making sure every large breed gets the right body-weight-based dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEasy to Give:\u003c\/strong\u003e The beef-flavored tablet can be offered by hand, tucked into food, or given as a treat, making monthly dosing simple for large dog owners.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNo Drying Time Needed:\u003c\/strong\u003e Unlike topical treatments, there is no waiting period after giving this tablet; dogs can be handled and played with straight away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWidely Trusted Formula:\u003c\/strong\u003e Over 272 million doses across nearly ten years show how consistently this tablet has performed for dogs and their owners.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eActive Ingredients (per tablet, 60.1–120 lb dogs)\u003c\/h4\u003e\n\u003cp\u003eSpinosad 1620 mg, Milbemycin Oxime 27 mg\u003c\/p\u003e\n\u003ch4\u003eOther Ingredients\u003c\/h4\u003e\n\u003cp\u003eThe beef flavoring in this tablet comes from artificial beef flavoring derived from pork-based proteins and hydrolyzed soy, not from actual beef.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDosage \u0026amp; Administration Instructions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e This FDA-approved medication can only be obtained through a licensed veterinarian with a valid veterinarian-client-pet relationship in place.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonthly Oral Dose:\u003c\/strong\u003e Give one full chewable tablet by mouth once every month, keeping to roughly the same date each time for consistent year-round coverage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAlways Give With Food:\u003c\/strong\u003e This tablet must be given alongside a meal for best absorption; giving it on an empty stomach can reduce how well it works.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHow to Offer the Tablet:\u003c\/strong\u003e The tablet can be handed over directly, stirred into food, or hidden inside a treat; it is made to be palatable for large dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWatch After Dosing:\u003c\/strong\u003e Keep an eye on your dog for one hour after giving the tablet; if vomiting happens within that window, give a full replacement dose right away.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMinimum Dose:\u003c\/strong\u003e Each tablet delivers at least 13.5 mg\/lb (30 mg\/kg) Spinosad and 0.2 mg\/lb (0.5 mg\/kg) Milbemycin Oxime per dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDogs Over 120 lbs:\u003c\/strong\u003e Your veterinarian will advise on the right combination of tablet sizes to reach the correct total dose for heavier dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSeasonal Use:\u003c\/strong\u003e When used during mosquito season only, begin dosing within one month of first mosquito exposure and continue for at least three months after the last.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMissed Dose:\u003c\/strong\u003e If more than 30 days pass between doses, give the tablet with food right away and carry on with the regular monthly schedule from that point.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMinimum Age and Weight:\u003c\/strong\u003e Safe for puppies that are at least 8 weeks old and have reached a body weight of 5 pounds.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any medication for your pet.\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHeartworm Screening First:\u003c\/strong\u003e Every dog should be checked for heartworm by a vet before the first dose, as adult heartworm infections already in the body are beyond what this product can treat.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot for Adult Heartworms:\u003c\/strong\u003e This product does not clear adult Dirofilaria immitis; dogs confirmed positive should go through adulticide therapy before starting this product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eThree Doses for Full Cover:\u003c\/strong\u003e Fewer than three back-to-back monthly doses after the final mosquito exposure may leave gaps in heartworm prevention for your large dog.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Use With Ivermectin:\u003c\/strong\u003e Serious reactions have been reported when Spinosad is combined with ivermectin; always tell your vet about every medication your dog is currently on.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDogs Only:\u003c\/strong\u003e This product was developed solely for dogs and must not be given to cats under any circumstances.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigh Microfilariae Counts:\u003c\/strong\u003e Dogs with a large number of circulating microfilariae may show brief, mild reactions such as laboured breathing, vomiting, or lethargy when given milbemycin oxime.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreeding Dogs:\u003c\/strong\u003e Check with your vet before giving this product to breeding females; safety in males intended for breeding has not been assessed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFleas After Dosing:\u003c\/strong\u003e Any fleas seen within a month of dosing are newly hatched from existing pupae in the surroundings; they will be killed before they can breed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWorms in Stool:\u003c\/strong\u003e Intestinal worms passed in your dog's stool after dosing are a normal sign that the product is doing its job correctly.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eVomiting:\u003c\/strong\u003e Monitor your dog closely for 60 minutes post-dose and give a complete second tablet right away if the first one comes back up.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDigestive Upset:\u003c\/strong\u003e Loose stools, a reduced appetite, or excessive drooling have been reported in some dogs following administration of this tablet.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLow Energy:\u003c\/strong\u003e A noticeable drop in activity levels and longer-than-usual sleep periods have been reported in some treated large dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSkin Reactions:\u003c\/strong\u003e Itching, skin reddening, and localised skin inflammation have been observed in a number of dogs after receiving this product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological Reactions:\u003c\/strong\u003e Trembling, shaking, poor coordination, and seizures have been reported post-approval; contact your vet right away if any of these appear.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSevere Allergic Reaction:\u003c\/strong\u003e Though rare, facial swelling, hives, very pale gums, sudden collapse, or cold limbs all require urgent emergency veterinary care.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage:\u003c\/strong\u003e Store it in a spot that stays between 68°F (20°C) and 77°F (25°C) and keep this product there consistently.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSafe Storage Practice:\u003c\/strong\u003e Store this prescription product well out of reach of children and other household animals to prevent any accidental ingestion.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/en-ca\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ca\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What parasites does Trifexis (Brown Box) protect large dogs against?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Trifexis provides 5-in-1 coverage in one monthly tablet: it kills fleas, prevents heartworm disease, and treats adult hookworms, roundworms, and whipworms. It covers the most common parasites large dogs face but does not include protection against ticks.\u003c\/p\u003e\n\u003ch3\u003eQ2: How does the Brown Box formula differ from smaller Trifexis variants?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The Brown Box holds 1620 mg Spinosad and 27 mg Milbemycin Oxime per tablet, the highest dose across the full Trifexis range. The Blue Box for 40.1 to 60 lb dogs carries half that amount. All variants deliver the same five-way protection; the larger dose ensures full coverage for heavy breeds.\u003c\/p\u003e\n\u003ch3\u003eQ3: My large dog weighs more than 120 lbs. Can I still use Trifexis?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Yes, dogs over 120 pounds can still be treated using the right mix of available Trifexis tablet sizes to hit the correct total dose. Your vet will work out the exact combination needed. Never rely on a single Brown Box tablet alone for a dog above that weight threshold.\u003c\/p\u003e\n\u003ch3\u003eQ4: Can Trifexis be given to a large dog that already has heartworms?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e No. This product does not treat adult heartworms and is not cleared for that purpose. Every dog must be tested before starting. If a large dog tests positive, adulticide treatment should be completed first before this product is introduced as a preventive measure.\u003c\/p\u003e\n\u003ch3\u003eQ5: Does Trifexis contain anything that could affect dogs with food sensitivities?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The beef flavoring in this tablet comes from artificial beef flavoring using pork-based proteins and hydrolyzed soy, not real beef. Dogs with known soy or pork sensitivities should be checked with a vet before starting. The product does not contain gluten.\u003c\/p\u003e\n\u003ch2\u003eClinical Research\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.heartwormsociety.org\/pet-owner-resources\/heartworm-basics\" title=\"Heartworm basics - american heartworm society\" aria-label=\"Visit a webpage about Heartworm basics - american heartworm society\"\u003eAmerican Heartworm Society\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.avma.org\/resources-tools\/pet-owners\/petcare\/external-parasites\" title=\"External parasites | american veterinary medical association\" aria-label=\"Visit a webpage about External parasites | american veterinary medical association\"\u003eAmerican Veterinary Medical Association (AVMA)\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.petsandparasites.org\/dog-owners\/overview\" title=\"Overview | pets \u0026amp; parasites: the pet owner’s parasite resource\" aria-label=\"Visit a webpage about Overview | pets \u0026amp; parasites: the pet owner’s parasite resource\"\u003eCompanion Animal Parasite Council (CAPC)\u003c\/a\u003e\u003c\/p\u003e","brand":"Elanco","offers":[{"title":"1 Chewable Tablet (1 Month Supply)","offer_id":41109202665633,"sku":"CA4336Y07AM-1","price":44.0,"currency_code":"CAD","in_stock":true},{"title":"6 Chewable Tablets (6 Months Supply)","offer_id":41109202698401,"sku":"CA4336Y07AM","price":259.0,"currency_code":"CAD","in_stock":true},{"title":"12 Chewable Tablets (12 Months Supply)","offer_id":44200296841377,"sku":"CA4336Y07AM-PK2","price":517.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/trifexis-chewable-tablets-for-dogs-60-1-120-lbs-spinosad-374.jpg?v=1778102087","url":"https:\/\/hardypaw.com\/en-ca\/products\/trifexis-flea-worm-chewable-tablets-for-extra-large-dogs-brown-box","provider":"HardyPaw","version":"1.0","type":"link"}