{"product_id":"barrier-topical-solution-dogs-yellow-box","title":"Barrier Topical Solution for Dogs, 88.1-110 lbs, (Yellow)","description":"\u003cp align=\"center\"\u003e\u003cimg width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/hardypaw.com\/cdn\/shop\/files\/rx-map.webp\" loading=\"lazy\" data-original=\"https:\/\/hardypaw.com\/cdn\/shop\/files\/rx-map.webp\" data-files=\"rx-map.webp\"\u003e\u003c\/p\u003e\n\u003ch2\u003eMonthly 6-in-1 Spot-On for Heartworm, Fleas and Parasites in Large Dogs\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eBarrier Topical Solution (88.1 to 110 lbs) is an FDA-approved, prescription-only monthly spot-on for dogs and puppies 7 weeks or older weighing 88.1 to 110 lbs. Each 5 mL tube delivers 10% imidacloprid and 2.5% moxidectin, the same active ingredients as Advantage Multi for Dogs. One monthly dose prevents heartworm, treats microfilariae, \u003ca href=\"\/en-hk\/collections\/dog-flea-tick-medications\" title=\"Dog flea \u0026amp; tick medications: fast \u0026amp; effective protection | hardypaw\" aria-label=\"Dog flea \u0026amp; tick medications: fast \u0026amp; effective protection | hardypaw\"\u003ekills adult fleas\u003c\/a\u003e, treats intestinal worms, and controls sarcoptic mange in large dogs.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrevents Heartworm Disease:\u003c\/strong\u003e Moxidectin prevents Dirofilaria immitis larval development into adult heartworms when applied once monthly to large dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Circulating Microfilariae:\u003c\/strong\u003e Unlike many preventives, Barrier for Dogs also treats existing Dirofilaria immitis circulating microfilariae in heartworm-positive dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKills Adult Fleas:\u003c\/strong\u003e Imidacloprid kills adult fleas fast, providing effective flea treatment and preventing flea infestations with each monthly dose.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Intestinal Worms:\u003c\/strong\u003e Effectively treats and \u003ca href=\"\/en-hk\/collections\/dog-dewormers\" title=\"Dog dewormers: best tapeworm, hookworm \u0026amp; roundworm treatment | hardypaw\" aria-label=\"Dog dewormers: best tapeworm, hookworm \u0026amp; roundworm treatment | hardypaw\"\u003econtrols intestinal infections\u003c\/a\u003e caused by hookworms, roundworms, and whipworms in large dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Sarcoptic Mange:\u003c\/strong\u003e Treats and controls sarcoptic mange (Sarcoptes scabiei) infestations in large dogs with each monthly topical application.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHigher Moxidectin Concentration:\u003c\/strong\u003e Contains 2.5% moxidectin, significantly higher than the cat formulation, providing the dose required for large dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSame Ingredients, Better Value:\u003c\/strong\u003e Contains the same active ingredients as Advantage Multi for Dogs, offering equivalent six-in-one parasite protection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMade in the USA:\u003c\/strong\u003e Manufactured and packaged in the USA from a registered FDA facility, ensuring quality and regulatory compliance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eComposition Table\u003c\/h4\u003e\n\u003ctable\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd\u003e\u003cstrong\u003eIngredient\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd\u003e\u003cstrong\u003eQuantity\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eImidacloprid\u003c\/td\u003e\n\u003ctd\u003e10% (500 mg per 5.0 mL tube)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd\u003eMoxidectin\u003c\/td\u003e\n\u003ctd\u003e2.5% (125 mg per 5.0 mL tube)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003eOther Ingredients\u003c\/h4\u003e\n\u003cp\u003eBenzyl alcohol, Propylene carbonate\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDirections for Use\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e Federal law in the US permits use of this medicine only as directed by a licensed veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDog Must Be Standing:\u003c\/strong\u003e Have your large dog standing throughout the entire application process to ensure even solution distribution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOpen the Tube Correctly:\u003c\/strong\u003e Position the tube vertically, turn the cap to break the seal, and apply without removing the cap.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApply Along the Backline:\u003c\/strong\u003e Part the hair and apply the entire contents at 3 to 4 spots along the top of the backline from the neck.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSqueeze Entire Contents:\u003c\/strong\u003e Apply directly onto the skin at each spot and allow the area to dry naturally without rubbing the product in.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLift Tube Before Releasing:\u003c\/strong\u003e Remove the tube from the skin before releasing pressure to prevent the solution from being drawn back in.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApply Once Monthly:\u003c\/strong\u003e Administer every 30 days for \u003ca href=\"\/en-hk\/collections\/dog-heartworm-preventives\" title=\"Dog heartworm prevention: monthly chews \u0026amp; medication | hardypaw\" aria-label=\"Dog heartworm prevention: monthly chews \u0026amp; medication | hardypaw\"\u003econtinuous heartworm prevention\u003c\/a\u003e, flea control, and parasite protection throughout the year.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrevent Post-Application Licking:\u003c\/strong\u003e Keep the dog from licking application sites for 30 minutes and separate treated animals from other pets.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eTest for Heartworm First:\u003c\/strong\u003e Test all dogs for existing heartworm infection before starting Barrier; consult your veterinarian about adulticide treatment if needed.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eMinimum Age and Weight:\u003c\/strong\u003e Not suitable for dogs younger than 7 weeks or lighter than 3 lbs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNever Use on Cats:\u003c\/strong\u003e This dog formulation contains 2.5% moxidectin, far higher than the cat formula, and can be fatal to cats.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDo Not Give Orally:\u003c\/strong\u003e Never administer this product orally; ingestion may cause depression, salivation, dilated pupils, incoordination, panting, and muscle tremors.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvermectin-Sensitive Dogs:\u003c\/strong\u003e In MDR1-mutation dogs, accidental oral ingestion may cause severe reactions including coma and death; use with extreme caution.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSick or Debilitated Dogs:\u003c\/strong\u003e Use with caution in sick, debilitated, or underweight animals and always seek veterinary guidance before applying Barrier.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBreeding, Pregnant, Lactating Dogs:\u003c\/strong\u003e Safety has not been established in breeding, pregnant, or lactating dogs; consult your veterinarian before use.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep Children Away:\u003c\/strong\u003e Children should not come into contact with the application sites for two hours after applying the product.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eEye Irritant for Humans:\u003c\/strong\u003e Rinse eyes with water for 15 minutes if exposure happens, and make sure to wash hands properly with soap and water afterward.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHematochezia and Diarrhea:\u003c\/strong\u003e Blood in stool and diarrhea have been reported in field studies; contact your veterinarian if these occur.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVomiting and Inappetence:\u003c\/strong\u003e Vomiting and reduced appetite have been reported following treatment in field safety studies with dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLethargy and Pyoderma:\u003c\/strong\u003e Lethargy and skin infection at the application site have been reported in dogs during field studies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNeurological Signs:\u003c\/strong\u003e Weakness, depression, and unsteadiness have been reported in dogs after application; contact your veterinarian immediately if observed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eApplication Site Reactions:\u003c\/strong\u003e \u003ca href=\"\/en-hk\/collections\/dog-hot-spot-itch-relief\" title=\"Dog hot spot \u0026amp; itch relief: shop top products \u0026amp; treatments | hardypaw\" aria-label=\"Dog hot spot \u0026amp; itch relief: shop top products \u0026amp; treatments | hardypaw\"\u003eLocalized itching\u003c\/a\u003e and hyperkeratosis at the application site have been reported in dogs with pre-existing flea allergy dermatitis.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eStore at Cool Temperature:\u003c\/strong\u003e Store between 4°C (39°F) and 25°C (77°F); avoid exposure to excess heat or cold at all times.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSecure Storage Required:\u003c\/strong\u003e Store this prescription product securely out of reach of children and other animals at all times.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/en-hk\/pages\/shipping-policy\" title=\"Shipping policy\" aria-label=\"Shipping policy\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-hk\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What does Barrier Topical Solution (88.1 to 110 lbs) treat in large dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Barrier for Large Dogs is a once-a-month topical treatment that protects dogs 7 weeks and older by preventing heartworm, killing adult fleas, \u003ca href=\"\/en-hk\/collections\/dog-flea-tick\" title=\"Dog tick \u0026amp; flea: best products for prevention \u0026amp; treatment | hardypaw\" aria-label=\"Dog tick \u0026amp; flea: best products for prevention \u0026amp; treatment | hardypaw\"\u003etreating flea infestations\u003c\/a\u003e, addressing circulating microfilariae, and controlling hookworms, roundworms, whipworms, and sarcoptic mange.\u003c\/p\u003e\n\u003ch3\u003eQ2: Can the large dog heartworm spot-on be used on dogs over 110 lbs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e For dogs over 110 lbs, the appropriate combination of Barrier tube sizes should be used to achieve the correct total dose of 4.5 mg\/lb imidacloprid and 1.1 mg\/lb moxidectin, as directed by your veterinarian. Never rely on a single 88.1 to 110 lbs tube alone.\u003c\/p\u003e\n\u003ch3\u003eQ3: Can Barrier for Dogs treat a heartworm-positive dog?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Yes. Barrier for Dogs is indicated for the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. It does not eliminate adult heartworms, so veterinarians may also recommend adulticide treatment to remove existing adult worms alongside the microfilariae treatment protocol.\u003c\/p\u003e\n\u003ch3\u003eQ4: Is the large dog monthly spot-on safe for herding or avermectin-sensitive breeds?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Barrier contains moxidectin, a macrocyclic lactone similar to ivermectin. In avermectin-sensitive breeds carrying the MDR1 gene mutation, such as Collies and Australian Shepherds, accidental oral ingestion can cause severe reactions including coma and death. Always consult your veterinarian before use in herding breeds.\u003c\/p\u003e\n\u003ch3\u003eQ5: How does the large dog spot-on compare to Advantage Multi for Dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Barrier for Dogs and Advantage Multi for Dogs contain identical active ingredients, 10% imidacloprid and 2.5% moxidectin, at the same concentrations, providing equivalent six-in-one parasite protection. Both are FDA-approved monthly prescription topicals, with the primary difference being the brand name and price point.\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/npic.orst.edu\/factsheets\/imidagen.html\" title=\"Imidacloprid general fact sheet\" aria-label=\"Visit a webpage about Imidacloprid general fact sheet\"\u003eImidacloprid – NPIC (National Pesticide Information Center)\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/wcvm.usask.ca\/learnaboutparasites\/parasites\/dirofilaria-immitis.php\" title=\"Dirofilaria immitis - learn about parasites - western college of veterinary medicine | university of saskatchewan\" aria-label=\"Visit a webpage about Dirofilaria immitis - learn about parasites - western college of veterinary medicine | university of saskatchewan\"\u003eDirofilaria immitis (Heartworm) – University of Saskatchewan (WCVM)\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.sciencedirect.com\/topics\/agricultural-and-biological-sciences\/moxidectin\" title=\"Moxidectin – sciencedirect\" aria-label=\"Visit a webpage about Moxidectin – sciencedirect\"\u003eMoxidectin – ScienceDirect\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/vcahospitals.com\/know-your-pet\/mange-sarcoptic-in-dogs\" title=\"Sarcoptic mange – vca animal hospitals\" aria-label=\"Visit a webpage about Sarcoptic mange – vca animal hospitals\"\u003eSarcoptic Mange – VCA Animal Hospitals\u003c\/a\u003e\u003c\/p\u003e","brand":"Aurora Pharmaceutical","offers":[{"title":"1 Dose (1-mos. supply)","offer_id":44288821362849,"sku":"5107210005-1","price":88.0,"currency_code":"HKD","in_stock":true},{"title":"6 Doses (6-mos. supply)","offer_id":44288821395617,"sku":"5107210005","price":509.0,"currency_code":"HKD","in_stock":true},{"title":"12 Doses (12-mos. supply)","offer_id":44288821428385,"sku":"5107210005-PK2","price":1002.0,"currency_code":"HKD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/barrier-topical-solution-for-dogs-88-1-110-lbs-yellow-1-dose-1-246.jpg?v=1777932725","url":"https:\/\/hardypaw.com\/en-hk\/products\/barrier-topical-solution-dogs-yellow-box","provider":"HardyPaw","version":"1.0","type":"link"}