{"product_id":"dechra-osphos-clodronate-injection-horses","title":"Osphos (clodronate) Injection for Horses 60mg\/mL (15 mL)","description":"\u003cp align=\"center\"\u003e\u003cimg width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/hardypaw.com\/cdn\/shop\/files\/rx-map.webp\" data-original=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\" data-files=\"rx-map.jpg\" loading=\"lazy\"\u003e\u003c\/p\u003e\n\u003ch2\u003eAdvanced Pain Relief for Horses’ Navicular Syndrome\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eOSPHOS® is a bisphosphonate injection given by veterinarians to manage lameness in horses due to navicular syndrome. This one-time treatment helps decrease bone resorption and enhances comfort in the forelimbs. Clinical studies show that many horses experience significant improvement in just two months, and many continue to benefit for up to six months. OSPHOS® offers a scientifically backed solution for horses dealing with pain and lameness.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eRapid Relief:\u003c\/strong\u003e Horses often show improvement in lameness within two months post-treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLong-lasting Effects:\u003c\/strong\u003e Many horses maintain reduced clinical signs for up to six months.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eScientifically Proven:\u003c\/strong\u003e Effectiveness validated in controlled field studies with measurable outcomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVeterinarian Approved:\u003c\/strong\u003e Administered under professional supervision to ensure safety and proper dosage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eImproves Comfort:\u003c\/strong\u003e Reduces discomfort, nervousness, and pawing associated with navicular syndrome.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBone Health Support:\u003c\/strong\u003e Inhibits osteoclast activity to limit bone resorption without impacting overall bone density.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eActive Ingredients\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cp\u003eClodronate disodium tetrahydrate 74.98 mg\/mL (equivalent to 60 mg\/mL clodronate disodium)\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 49.3341%; height: 46px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd width=\"82\" style=\"width: 14.4004%; height: 55.1989px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eHorse Weight\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"127\" style=\"width: 22.5006%; height: 55.1989px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eRecommended Dose\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"100\" style=\"width: 17.6405%; height: 55.1989px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eMaximum Dose\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"256\" style=\"width: 44.4613%; height: 55.1989px;\"\u003e\n\u003cp\u003e\u003cstrong\u003eInjection Sites\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd width=\"82\" style=\"width: 14.4004%; height: 55.1989px;\"\u003e\n\u003cp\u003eAll weights\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"127\" style=\"width: 22.5006%; height: 55.1989px;\"\u003e\n\u003cp\u003e1.8 mg\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"100\" style=\"width: 17.6405%; height: 55.1989px;\"\u003e\n\u003cp\u003e900 mg per horse\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"256\" style=\"width: 44.4613%; height: 55.1989px;\"\u003e\n\u003cp\u003eDivide evenly into 3 separate intramuscular sites\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eSingle Dose Use:\u003c\/strong\u003e Administer a single intramuscular injection per treatment session for optimal effect.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDivide Injections: \u003c\/strong\u003eDistribute the total dose evenly among three different injection sites to minimize discomfort.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMaximum Volume Limit:\u003c\/strong\u003e Make sure that each injection site does not exceed 15 mL for safety and proper absorption.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitor Response:\u003c\/strong\u003e Watch the horses for at least two hours post-injection for any clinical signs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Requirement: \u003c\/strong\u003eOSPHOS® needs a prescription and should be administered by or under the guidance of a licensed veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRe-administration Guidelines: \u003c\/strong\u003eIf improvement decreases, re-administer every 3 to 6 months based on the return of clinical signs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAge Restriction:\u003c\/strong\u003e Not evaluated for horses less than 4 years old due to possible effects on their developing bones.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnant Mares:\u003c\/strong\u003e Should not be used in pregnant or lactating mares because of potential risks to the fetus.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eRenal Function: \u003c\/strong\u003eAvoid in horses with kidney dysfunction or those on nephrotoxic medications.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMineral Imbalance: \u003c\/strong\u003eUse caution in horses with electrolyte disorders, as bisphosphonates can temporarily change mineral levels.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHuman Safety: \u003c\/strong\u003eKeep away from humans; not for human consumption, and in case of accidental exposure, seek medical advice.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eColic and Pawing:\u003c\/strong\u003e Some horses may experience colic, pawing, or abdominal discomfort shortly after injection.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNervousness or Agitation:\u003c\/strong\u003e Horses may show signs of restlessness, circling, or tail twitching post-treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCNS Signs:\u003c\/strong\u003e Yawning, flehmen, head shaking, or neck writhing can occur temporarily after administration.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eInjection Site Reactions: \u003c\/strong\u003eThere may be mild to moderate swelling at the injection site, which usually resolves in about 10 days\u003cstrong\u003e.\u003c\/strong\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLaboratory Changes:\u003c\/strong\u003e Transient increases in BUN, creatinine, or potassium may occur following treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature Management: \u003c\/strong\u003eKeep at 25°C, allowing for variations between 15°C and 30°C to ensure the drug remains stable.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSingle-Use Vial: \u003c\/strong\u003eThrow away any leftover portion after injection to avoid contamination.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOriginal Packaging:\u003c\/strong\u003e Keep in original carton until use to protect from light and maintain sterility.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/p\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e \u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: How does OSPHOS® help horses with navicular syndrome?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e OSPHOS® functions by blocking osteoclast activity and lowering bone resorption, which enhances comfort in the forelimbs and reduces lameness. Clinical research indicates that most horses see considerable improvement within two months, and many continue to enjoy benefits for as long as six months.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: What is the recommended dosage for OSPHOS®?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The recommended dosage is 1.8 mg\/kg via intramuscular injection, with a maximum limit of 900 mg for each horse, distributed over three distinct sites. If clinical signs return, re-administration can happen every 3–6 months.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: Can OSPHOS® be used in young or pregnant horses?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e OSPHOS® is not tested on horses less than 4 years old or on pregnant or lactating mares due to potential risks to bones and fetuses. It should only be administered to adult horses under the guidance of a veterinarian.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: What side effects should I monitor after treatment?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Horses can show signs like colic, nervousness, pawing, yawning, head shaking, or swelling at the injection site soon after getting the shot. Most symptoms go away in a few hours, usually with some hand walking. If there are serious reactions, a vet should be consulted.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: Is OSPHOS® available without a prescription?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e No. OSPHOS® is a prescription-only medication and must be administered by or on the order of a licensed veterinarian to ensure proper dosing and safety.\u003c\/p\u003e\n\u003ch2\u003eClinical Researches\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/dta.3050\" title=\"Https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/dta.3050\" aria-label=\"Visit a webpage about Https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/dta.3050\"\u003ehttps:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/abs\/10.1002\/dta.3050\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/beva.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/evj.13244\" title=\"Https:\/\/beva.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/evj.13244\" aria-label=\"Visit a webpage about Https:\/\/beva.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/evj.13244\"\u003ehttps:\/\/beva.onlinelibrary.wiley.com\/doi\/abs\/10.1111\/evj.13244\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/84\/8\/ajvr.23.03.0051.xml\" title=\"Pharmacokinetics and plasma protein binding of a single dose of clodronate disodium are similar for juvenile sheep and horses in: american journal of veterinary research volume 84 issue 8 (2023)\" aria-label=\"Visit a webpage about Pharmacokinetics and plasma protein binding of a single dose of clodronate disodium are similar for juvenile sheep and horses in: american journal of veterinary research volume 84 issue 8 (2023)\"\u003ehttps:\/\/avmajournals.avma.org\/view\/journals\/ajvr\/84\/8\/ajvr.23.03.0051.xml\u003c\/a\u003e\u003c\/p\u003e","brand":"Dechra","offers":[{"title":"Default Title","offer_id":43337616130209,"sku":"OSPHOS","price":2230.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/osphos-clodronate-injection-for-horses-60mg-ml-15-ml-pet-medicine-106.png?v=1778528920","url":"https:\/\/hardypaw.com\/en-ro\/products\/dechra-osphos-clodronate-injection-horses","provider":"HardyPaw","version":"1.0","type":"link"}