{"product_id":"dechra-vetoryl-capsules-trilostane-for-dogs-20mg","title":"Vetoryl Capsules (Trilostane) for Dogs - 20mg","description":"\u003ch2\u003eOnce-Daily Trilostane Capsule for Cushing's Disease in Dogs\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eVetoryl Capsules (Trilostane) 20 mg is an FDA-approved, prescription-only oral medication for managing Cushing's disease in dogs. Each capsule delivers 20 mg of trilostane, a synthetic steroid analogue that reversibly inhibits cortisol production in the adrenal cortex. Given once daily with food, it effectively manages both pituitary-dependent and adrenal-dependent forms of the disease, offering a precise intermediate dose option for small to medium-sized dogs.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eTreats Cushing's Disease:\u003c\/strong\u003e Indicated for both pituitary-dependent and adrenal-dependent hyperadrenocorticism, the two most common forms in dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAddresses Root Cause:\u003c\/strong\u003e Trilostane blocks excessive cortisol by reversibly inhibiting 3-beta-hydroxysteroid dehydrogenase within the adrenal cortex of dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eClinically Proven Results:\u003c\/strong\u003e Field studies showed improvement in signs like reduced thirst, urination, and panting in most dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOnce-Daily Convenience:\u003c\/strong\u003e Given orally once a day, making it straightforward to include in a dog's long-term daily routine.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrecise Intermediate Dose:\u003c\/strong\u003e The 20 mg capsule bridges the gap between 10 mg and 30 mg strengths for more accurate dosing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eReversible Suppression:\u003c\/strong\u003e Trilostane's cortisol inhibition is reversible, allowing therapy to be safely adjusted or stopped under veterinary guidance.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eComposition Table\u003c\/h4\u003e\n\u003ctable style=\"width: 36.1546%; height: 5px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 19.6023px;\"\u003e\n\u003ctd style=\"width: 37.9811%; height: 19.6023px;\"\u003e\u003cstrong\u003eIngredient\u003c\/strong\u003e\u003c\/td\u003e\n\u003ctd style=\"width: 61.7418%; height: 19.6023px;\"\u003e\u003cstrong\u003eQuantity\u003c\/strong\u003e\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 19.6023px;\"\u003e\n\u003ctd style=\"width: 37.9811%; height: 19.6023px;\"\u003eTrilostane\u003c\/td\u003e\n\u003ctd style=\"width: 61.7418%; height: 19.6023px;\"\u003e20 mg per capsule\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003eOther Ingredients\u003c\/h4\u003e\n\u003cp\u003eGelatin capsule shell, Lactose, Magnesium Stearate, Colloidal Silicon Dioxide\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDosage \u0026amp; Administration Instructions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrescription Required:\u003c\/strong\u003e US law requires this drug to be given only when prescribed or directed by a licensed veterinarian.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFor Dogs Only:\u003c\/strong\u003e Intended for oral use in dogs only and must not be given to humans or other animal species.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eGive With Food:\u003c\/strong\u003e Administer orally once daily, preferably in the morning with food to improve absorption and reduce stomach upset.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDo Not Divide Capsules:\u003c\/strong\u003e Never empty the capsule contents or split it; always administer the whole capsule as dispensed.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eMonitor After Starting:\u003c\/strong\u003e Around 10 to 14 days in, a re-examination, ACTH stimulation test, and serum biochemical panel should be conducted.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDose Adjustments:\u003c\/strong\u003e Any changes to the dose should be based on ACTH stimulation results and made under your veterinarian's guidance.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStop If Side Effects Occur:\u003c\/strong\u003e Stop therapy immediately and contact your veterinarian if vomiting, diarrhea, lethargy, appetite loss, or collapse occurs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWash Hands After Handling:\u003c\/strong\u003e Always wash hands thoroughly with soap and water after handling the capsules each time.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eHypersensitivity Contraindication:\u003c\/strong\u003e Do not use in dogs that have previously shown an allergic reaction or hypersensitivity to trilostane.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver or Kidney Disease:\u003c\/strong\u003e Dogs with hepatic disease or poor kidney function should not receive Vetoryl, and organ tests should be done first.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eNot for Pregnant Dogs:\u003c\/strong\u003e Trilostane has caused teratogenic effects and early pregnancy loss in lab animals; never use in pregnant dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePregnant Handlers:\u003c\/strong\u003e Women who are pregnant or trying to conceive must never handle Vetoryl capsules due to teratogenic risks.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAdrenal Over-Suppression Risk:\u003c\/strong\u003e Addison's disease can develop at any dose and some dogs may never fully regain normal adrenal function.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eCaution With Heart Medications:\u003c\/strong\u003e Use with caution in dogs on heart disease medications; inform your veterinarian of all current medications beforehand.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePrior Mitotane Treatment:\u003c\/strong\u003e Wait at least one month after stopping mitotane and until ACTH levels normalize before starting Vetoryl therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLactating and Breeding Males:\u003c\/strong\u003e The safety of Vetoryl has not been evaluated in lactating dogs or males intended for breeding.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eAnorexia and Vomiting:\u003c\/strong\u003e Loss of appetite and vomiting are among the most commonly reported side effects; contact your vet immediately.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLethargy and Weakness:\u003c\/strong\u003e Depression, reduced activity, and physical weakness have been frequently reported in both field studies and post-approval experience.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDiarrhea:\u003c\/strong\u003e Loose stools or diarrhea have been reported; monitor your dog's bowel movements and report any changes promptly.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElevated Liver Enzymes:\u003c\/strong\u003e Elevated hepatic enzyme levels have been reported; routine biochemical monitoring helps detect these changes at an early stage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eElectrolyte Imbalances:\u003c\/strong\u003e Elevated potassium and decreased sodium levels have been reported and may signal adrenal over-suppression in treated dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eSerious Adverse Events:\u003c\/strong\u003e Death has been reported in some cases; contact your veterinarian immediately if sudden collapse or rapid deterioration occurs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul type=\"disc\"\u003e\n\u003cli\u003e\n\u003cstrong\u003eRoom Temperature Storage:\u003c\/strong\u003e Store at room temperature 25°C (77°F), with excursions permitted between 15°C and 30°C (59°F to 86°F).\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eKeep Away from Children and Pets:\u003c\/strong\u003e Store this prescription medication securely out of reach of children and other animals at all times.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/en-ro\/pages\/shipping-policy\" title=\"Shipping policy | hardypaw\" aria-label=\"Shipping policy | hardypaw\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/en-ro\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE.\u003c\/strong\u003e\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What condition does Vetoryl (Trilostane) 20 mg treat in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Vetoryl Capsules treat hyperadrenocorticism, commonly known as Cushing's disease, in dogs. It works for both pituitary-dependent and adrenal-dependent forms of the disease, where excess cortisol is produced by either a pituitary or adrenal gland tumor, causing various clinical signs.\u003c\/p\u003e\n\u003ch3\u003eQ2: How is the 20 mg capsule different from other Vetoryl strengths?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e The 20 mg trilostane capsule provides an intermediate option between the 10 mg and 30 mg strengths. It allows veterinarians to prescribe a more accurate weight-based dose for dogs whose ideal dose falls between those two strengths, avoiding unnecessary over or under-dosing.\u003c\/p\u003e\n\u003ch3\u003eQ3: How quickly does Vetoryl 20 mg start working in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Clinical field studies showed improvement in most dogs within 14 days of starting Vetoryl. Early signs include reduced thirst, less urination, decreased panting, and better appetite. A follow-up ACTH stimulation test is conducted after the first 10 to 14 days.\u003c\/p\u003e\n\u003ch3\u003eQ4: Why does my dog need regular testing while on Vetoryl?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Regular ACTH stimulation tests and biochemical panels are required because Vetoryl can cause adrenal over-suppression at any dose, leading to Addison's disease. Monitoring keeps cortisol within a safe range and allows your veterinarian to adjust the dose appropriately and safely over time.\u003c\/p\u003e\n\u003ch3\u003eQ5: Is the Cushing's disease trilostane capsule a permanent cure for dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e No. Vetoryl controls the signs of Cushing's disease by suppressing excess cortisol but does not cure the underlying condition. If the medication is stopped or missed regularly, cortisol levels will rise again and signs will return, making lifelong therapy typically necessary for dogs.\u003c\/p\u003e\n\u003ch2\u003eClinical Research\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/855\" title=\"Fda - vetoryl drug approval\" aria-label=\"Visit a webpage about Fda - vetoryl drug approval\"\u003eFDA - Vetoryl Drug Approval\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.msdvetmanual.com\/endocrine-system\/the-pituitary-gland\/cushing-disease-pituitary-dependent-hyperadrenocorticism-in-animals\" title=\"Cushing disease (pituitary-dependent hyperadrenocorticism) in animals - endocrine system - msd veterinary manual\" aria-label=\"Visit a webpage about Cushing disease (pituitary-dependent hyperadrenocorticism) in animals - endocrine system - msd veterinary manual\"\u003eMerck Veterinary Manual – Cushing's Syndrome in Dogs\u003c\/a\u003e\u003c\/p\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/www.petmd.com\/pet-medication\/vetoryl\" title=\"Vetoryl® (trilostane) | medication: petmd | petmd\" aria-label=\"Visit a webpage about Vetoryl® (trilostane) | medication: petmd | petmd\"\u003ePetMD – Trilostane for Dogs\u003c\/a\u003e\u003c\/p\u003e","brand":"Dechra","offers":[{"title":"30 Capsules","offer_id":44670645338273,"sku":"VET-020","price":555.0,"currency_code":"RON","in_stock":true},{"title":"60 Capsules","offer_id":44670645371041,"sku":"VET-020-60","price":1109.0,"currency_code":"RON","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/vetoryl-capsules-trilostane-for-dogs-20mg-pet-medicine-262.webp?v=1777974407","url":"https:\/\/hardypaw.com\/en-ro\/products\/dechra-vetoryl-capsules-trilostane-for-dogs-20mg","provider":"HardyPaw","version":"1.0","type":"link"}