Factrel Injection (gonadorelin injection) for Cattle

GnRH Injection for Ovarian Cysts and FTAI in Cattle

Product Description

Factrel (Gonadorelin Hydrochloride) Injection 50 mcg/mL is an FDA-approved prescription GnRH solution for intramuscular use in cattle only. Each mL contains 50 mcg synthetic gonadorelin identical in amino acid sequence to natural bovine GnRH, in sodium chloride with benzyl alcohol as preservative. It treats ovarian follicular cysts and synchronizes estrous cycles for FTAI when used with LUTALYSE, with no withdrawal period.

Benefits

• Treats Ovarian Follicular Cysts: Cuts down days to first estrus in lactating dairy cows, beef cows, and replacement heifers dealing with ovarian follicular cysts.
• Induces Endogenous LH Release: Stimulates the anterior pituitary to release endogenous LH and FSH, triggering ovulation or luteinization of cystic ovarian follicles.
• FTAI Protocol Compatible: Used with LUTALYSE in validated estrous synchronization protocols to allow fixed-time artificial insemination in dairy cows.
• Significantly Improves FTAI Rates: In a 1,142-cow study, Factrel with LUTALYSE reached up to 32.2% pregnancy rates versus 17.1% for LUTALYSE alone.
• No Withdrawal Period: No milk discard or preslaughter waiting period is needed for cattle treated with Factrel as directed.
• Bioidentical to Natural GnRH: Gonadorelin in Factrel shares the exact amino acid sequence as naturally occurring bovine hypothalamic GnRH in cattle.
• Wide Safety Margin: Given at up to 12.5 times the label dose for 3 days with no adverse physiological effects seen in safety studies.

Variants

Factrel Injection 20 mL Multi-Dose Vial

Factrel Injection 50 mL Multi-Dose Vial

Ingredients

Active Ingredients

Gonadorelin (as Gonadorelin Hydrochloride): 50 mcg per mL

Inactive Ingredients

Sodium chloride 0.6%, benzyl alcohol 2% (as preservative), water for injection

How to Use

Dosage and Administration Instructions

• Prescription Required: Federal law restricts Factrel Injection to use by or on the order of a licensed veterinarian only.
• Cystic Ovary Dose: Give 2 mL (100 mcg) as a single IM injection per cow to treat ovarian follicular cysts.
• FTAI Protocol Dose: Give 2 to 4 mL (100 to 200 mcg) per cow as both the first and second IM injection in the LUTALYSE-based FTAI protocol.
• FTAI Day 0: Give the first Factrel dose of 2 to 4 mL by IM injection on Day 0 to kick off the synchronization protocol.
• FTAI Day 6-8: Give 25 mg LUTALYSE (5 mL dinoprost tromethamine) by IM injection 6 to 8 days after the first Factrel dose.
• FTAI Day 8-10: Give the second Factrel dose of 2 to 4 mL between 30 and 72 hours after LUTALYSE is given.
• FTAI Timing: Perform FTAI within 0 to 24 hours after the second Factrel dose or on detected estrus.
• Vial Use Window: Once the vial is first opened, use the contents within one month and discard anything left after that.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Cattle Only: Factrel Injection is approved for intramuscular use in cattle only; do not administer to other animal species.
• Cyst Treatment Outcomes: Factrel cut days to first estrus in cyst-treated cows but did not significantly improve conception rates when used on its own.
• Only Use With LUTALYSE: The FTAI indication requires LUTALYSE specifically; do not swap in other prostaglandins without veterinary guidance.
• Human Safety: For animal use only; keep well away from children and never use on or near humans at any time.

Possible Side Effects

• No Adverse Events: No injection site irritation or physiological effects were seen even at 12.5 times the label dose in safety studies.
• Incidental Health Events: In the 1,142-cow field study, health events like mastitis, lameness, and pneumonia were noted but considered unrelated to Factrel.

Storage Information

• Refrigerator Storage Required: Store at 2 to 8°C (36 to 46°F); brief exposure up to 25°C (77°F) is tolerated but should be kept to a minimum.
• Use Within 1 Month: After the vial is first opened, throw out any unused solution one month later to keep the product sterile.
• Keep Out of Reach: Store in a locked, secure spot away from children and all animals at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is Factrel gonadorelin injection used for in cattle?

Ans: Factrel is FDA-approved for two uses in cattle: treating ovarian follicular cysts in lactating dairy cows, beef cows, and replacement heifers to cut down days to first estrus, and syncing estrous cycles for fixed-time artificial insemination in lactating dairy cows when paired with LUTALYSE Injection.

Q2: What is the correct dose of Factrel GnRH injection for cattle?

Ans: For ovarian cysts, give 2 mL (100 mcg) as a single IM injection per cow. For FTAI with LUTALYSE, give 2 to 4 mL at Day 0 and again 30 to 72 hours after the LUTALYSE injection, then perform FTAI within 24 hours of the second dose.

Q3: Is there a milk discard or withdrawal period for Factrel gonadorelin in cattle?

Ans: No milk discard or preslaughter withdrawal is needed when Factrel is used according to the label. It works for both lactating dairy cows and beef cattle without any production downtime, which makes it a practical fit for day-to-day herd management programs.

Q4: What is the difference between the Factrel 20 mL and 50 mL vials?

Ans: Both vials contain the identical 50 mcg/mL gonadorelin hydrochloride concentration and formulation. The 20 mL vial (1,000 mcg total) suits smaller herds or shorter programs, while the 50 mL vial (2,500 mcg total) is economical for large-scale FTAI synchronization programs requiring higher volume.

Q5: How does Factrel GnRH injection treat ovarian cysts in dairy and beef cows?

Ans: When ovarian cysts develop from a failure of normal ovulation, Factrel pushes the anterior pituitary to release LH, which triggers the cystic follicle to ovulate or luteinize. This gets the cow back cycling sooner, though using Factrel alone did not show a significant boost in conception rates compared to untreated cows.