{"product_id":"dechra-laverdia-ca1-verdinexor-tablets-dogs-50mg","title":"Laverdia-CA1 Tablets (Verdinexor) for Dog Cancer Treatment - 50mg","description":"\u003cp align=\"center\"\u003e\u003cimg width=\"700\" alt=\"RX MAP\" class=\"img-responsive\" src=\"https:\/\/shopify-images-bucket.s3.us-west-2.amazonaws.com\/rx-map.jpg\"\u003e\u003c\/p\u003e\n\u003ch2\u003eOral Lymphoma Treatment Tablets for Dogs\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eProduct Description\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eLAVERDIA-CA1 (verdinexor tablets) is an orally administered medication for the treatment of lymphoma in dogs, and it must be used under veterinary guidance. Its mechanism involves selectively inhibiting nuclear export proteins that support the survival of cancer cells, thereby focusing on tumor cells that have genomic damage. It is given twice a week alongside food, offering a convenient at-home treatment option with specific tablet strengths tailored for individual dosing.\u003c\/p\u003e\n\u003cp\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003eNOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eBenefits\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTargets Lymphoma Cells:\u003c\/strong\u003e Selectively blocks the nuclear export protein CRM1, leading to the demise of cancer cells while largely protecting normal cells that possess healthy genomes.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eOral Administration:\u003c\/strong\u003e Available in tablet form, which enables easy at-home dosing under the guidance of a veterinarian, eliminating the need for frequent visits to the clinic.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFlexible Dosing:\u003c\/strong\u003e Various tablet strengths allow for adjustments in dosing according to the dog's weight, tolerance, and clinical response.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVeterinary Guided Therapy:\u003c\/strong\u003e It is advisable to administer this medication under the supervision of a veterinarian, particularly those skilled in cancer treatment protocols for dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eFood-Enhanced Absorption:\u003c\/strong\u003e Taking the medication with food enhances drug absorption and consistency, leading to more reliable therapeutic levels in the treated dogs.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eVariants\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e50 mg Tablets\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eIngredients\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eVerdinexor\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eHow to Use\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003eRecommended-Dosage Chart\u003c\/strong\u003e\u003c\/h4\u003e\n\u003ctable style=\"width: 42.3882%; height: 146px;\"\u003e\n\u003ctbody\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd style=\"width: 26.2807%; height: 55.1989px;\" width=\"148\"\u003e\n\u003cp\u003e\u003cstrong\u003eDog Weight (kg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.6607%; height: 55.1989px;\" width=\"139\"\u003e\n\u003cp\u003e\u003cstrong\u003eStarting Dose (mg\/kg)\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 48.6014%; height: 55.1989px;\" width=\"293\"\u003e\n\u003cp\u003e\u003cstrong\u003eFrequency\u003c\/strong\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd style=\"width: 26.2807%; height: 55.1989px;\" width=\"148\"\u003e\n\u003cp\u003e≥ 9 kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.6607%; height: 55.1989px;\" width=\"139\"\u003e\n\u003cp\u003e1.25 mg\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 48.6014%; height: 55.1989px;\" width=\"293\"\u003e\n\u003cp\u003eTwice weekly with at least 72 hours between doses\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd style=\"width: 26.2807%; height: 55.1989px;\" width=\"148\"\u003e\n\u003cp\u003eIf tolerated after 2 weeks\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.6607%; height: 55.1989px;\" width=\"139\"\u003e\n\u003cp\u003eIncrease to 1.5 mg\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 48.6014%; height: 55.1989px;\" width=\"293\"\u003e\n\u003cp\u003eTwice weekly with at least 72 hours between doses\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr style=\"height: 55.1989px;\"\u003e\n\u003ctd style=\"width: 26.2807%; height: 55.1989px;\" width=\"148\"\u003e\n\u003cp\u003eDose reduction if needed\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 24.6607%; height: 55.1989px;\" width=\"139\"\u003e\n\u003cp\u003eMinimum 1 mg\/kg\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd style=\"width: 48.6014%; height: 55.1989px;\" width=\"293\"\u003e\n\u003cp\u003eTwice weekly with at least 72 hours between doses\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch4\u003e\u003cstrong\u003eDosage \u0026amp; Administration Instructions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eFeed Before Dosing\u003c\/strong\u003e: Provide food immediately prior to administration because feeding improves absorption and helps achieve consistent therapeutic drug exposure.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eWear Protective Gloves\u003c\/strong\u003e: Use disposable chemotherapy-resistant gloves while handling tablets to prevent accidental exposure to this antineoplastic medication.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Crushing: \u003c\/strong\u003eAvoid dividing, crushing, or damaging tablets to maintain proper dosing and safe usage.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eVeterinary Use Only:\u003c\/strong\u003e This medication is available solely through a licensed veterinarian's prescription or direction.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eObserve Tolerance:\u003c\/strong\u003e Modifications in dosage or pauses in treatment may be necessary based on side effects and the veterinarian's evaluation during the course of treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003eDisclaimer:\u003c\/strong\u003e This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eAdditional Information\u003c\/strong\u003e\u003c\/h3\u003e\n\u003ch4\u003e\u003cstrong\u003ePrecautions\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eAvoid Breeding Dogs\u003c\/strong\u003e: Due to potential fertility effects and teratogenic risks, do not use in pregnant, lactating, or breeding dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eHealth Monitoring Required\u003c\/strong\u003e: Frequent monitoring of bloodwork and serum chemistry is recommended during treatment due to potential abnormalities.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eConcurrent Conditions Caution\u003c\/strong\u003e: Safety has not been evaluated in dogs with serious infections, organ disease, diabetes, or other malignancies.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eDrug Interaction Awareness\u003c\/strong\u003e: Due to possible interaction, exercise caution when using it alongside medications that are metabolized through glutathione pathways, including acetaminophen.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003cstrong\u003ePossible Side Effects\u003c\/strong\u003e\u003c\/p\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eGastrointestinal Reactions:\u003c\/strong\u003e Typical reactions include vomiting, diarrhea, decreased appetite, and weight loss throughout the course of treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLethargy:\u003c\/strong\u003e Dogs might show signs of lethargy, weakness, fever, or lowered activity levels while undergoing therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eBlood Changes:\u003c\/strong\u003e Hematological alterations such as thrombocytopenia, anemia, or changes in leukocyte counts may develop and necessitate monitoring. Kidney or\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eLiver Impact:\u003c\/strong\u003e Variations in kidney function indicators or liver enzyme levels have been noted during the treatment.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003e\u003cstrong\u003eStorage Information\u003c\/strong\u003e\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cstrong\u003eTemperature:\u003c\/strong\u003e Store the medication between 20°C and 25°C to maintain the product's stability.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003eStorage Safety:\u003c\/strong\u003e Medication must be kept in a secure place, away from children, pets, and other animals, to prevent accidental ingestion.\u003c\/li\u003e\n\u003cli\u003e\n\u003cstrong\u003ePackaging:\u003c\/strong\u003e Retain the medication in its original bottle, which should have a secure cap and desiccant to protect against moisture.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003e\u003cstrong\u003eShipping \u0026amp; Return\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, priority, and international delivery; see our \u003ca href=\"https:\/\/hardypaw.com\/pages\/shipping-policies\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"https:\/\/hardypaw.com\/policies\/refund-policy\"\u003erefund policy\u003c\/a\u003e. \u003c\/p\u003e\n\u003cp\u003e\u003cstrong\u003ePrescription items are NON-RETURNABLE and NON-REFUNDABLE. \u003c\/strong\u003e \u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003e\u003cstrong\u003eQ1: What is LAVERDIA-CA1 used for in dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e LAVERDIA-CA1 is prescribed for the treatment of lymphoma in dogs under veterinary supervision. It contains verdinexor, an inhibitor of nuclear export proteins, which contributes to the growth of cancer cells. It specifically targets tumor cells with genetic damage while preserving healthy cells.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ2: How is LAVERDIA-CA1 administered to dogs?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e LAVERDIA-CA1 is given orally twice a week, with at least 72 hours between each dose. Feed dogs immediately prior to administration to enhance the absorption of the medication. The tablets must not be split or crushed, and the dosage should consistently follow the veterinarian's guidance.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ3: Is LAVERDIA-CA1 a chemotherapy drug?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e LAVERDIA-CA1 is an antineoplastic drug utilized in the field of veterinary oncology. It is categorized as a selective inhibitor of nuclear export, specifically targeting cancerous cells as it functions as a chemotherapy agent. Always use protective handling measures, such as wearing gloves, during its administration.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ4: What side effects can occur with LAVERDIA-CA1 treatment?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Typical side effects are vomiting, diarrhea, reduced appetite, weight loss, and fatigue. Additionally, there might be changes in blood counts and fluctuations in kidney or liver function tests. Regular veterinarian assessment is advised to effectively address any negative reactions.\u003c\/p\u003e\n\u003ch3\u003e\u003cstrong\u003eQ5: Who should not handle LAVERDIA-CA1 tablets?\u003c\/strong\u003e\u003c\/h3\u003e\n\u003cp\u003e\u003cstrong\u003eAns:\u003c\/strong\u003e Expectant mothers, women who might become pregnant, and those who are breastfeeding should avoid handling LAVERDIA-CA1 or touching dog waste that has been treated due to possible risks to reproduction. Anyone giving the medication must wear gloves that are resistant to chemotherapy to prevent exposure.\u003c\/p\u003e\n\u003ch2\u003eAuthoritative Resources for Further Reading:\u003c\/h2\u003e\n\u003col\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/animaldrugsatfda.fda.gov\/adafda\/app\/search\/public\/document\/downloadFoi\/10270\"\u003eFDA: Laverdia-CA1 Approval Overview\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/vcahospitals.com\/know-your-pet\/lymphoma-in-dogs\"\u003eVCA Animal Hospitals: Lymphoma in Dogs\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/uwveterinarycare.wisc.edu\/oncology\/\"\u003eUniversity of Wisconsin Veterinary Care – Oncology Services\u003c\/a\u003e\u003c\/li\u003e\n\u003cli\u003e\u003ca href=\"https:\/\/www.petmd.com\/dog\/conditions\/cancer\/c_dg_lymphoma\"\u003ePetMD: Dog Cancer Overview\u003c\/a\u003e\u003c\/li\u003e\n\u003c\/ol\u003e","brand":"Dechra","offers":[{"title":"16 tablets","offer_id":43263185649825,"sku":"LBL-7010-00","price":445.99,"currency_code":"USD","in_stock":false},{"title":"50 tablets","offer_id":43263185682593,"sku":"LBL-7006-00","price":1299.99,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/laverdia50.png?v=1696527398","url":"https:\/\/hardypaw.com\/products\/dechra-laverdia-ca1-verdinexor-tablets-dogs-50mg","provider":"HardyPaw","version":"1.0","type":"link"}