Diroban Injection for Dogs
Fast-Acting Canine Heartworm Treatment
Diroban (melarsomine dihydrochloride) Injection for Dogs is a veterinary heartworm adulticide specifically indicated for the treatment of heartworm disease (Dirofilaria immitis) in dogs. This prescription-only treatment is administered by veterinarians and is designed to eliminate mature heartworms from the pulmonary arteries and right side of the heart in infected dogs.
Targeting the macrocyclic lactone-resistant strains of heartworms, Diroban offers a vital component in canine heartworm disease management, typically used in conjunction with supportive care and microfilaricidal therapy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
What are the Benefits of Diroban Injection for Dogs?
Diroban stands out as a trusted solution in heartworm treatment protocols, offering key benefits:
- Effectively kills adult heartworms (stages L5 and adults over 4 months old)
- Veterinarian-administered intramuscular injection, ensuring precise dosage and professional supervision
- Backed by clinical safety data, as per FDA-approved guidelines
- Reduced risk of thromboembolism when used as per American Heartworm Society recommendations
- Essential part of a three-dose protocol, increasing efficacy over single-dose regimens
Compared to less-regulated formulations or off-label use of arsenicals, Diroban is FDA-approved, stable, and specifically formulated for intramuscular delivery in dogs.
How Should Diroban Be Administered to Dogs? (Dosage and Administration)
Always consult your veterinary for exact dosage instructions depending on your pet's condition.
Typical treatment protocol includes:
- Two-dose regimen: 2.5 mg/kg intramuscularly in lumbar muscles, administered 24 hours apart (for mild cases).
- Three-dose regimen: Single dose (2.5 mg/kg), followed by two doses a month later, 24 hours apart.
This staged protocol helps reduce pulmonary thromboembolic complications, especially in dogs with moderate to severe infestations.
What Ingredients Are in Diroban Injection?
|
Component |
Function |
|
Melarsomine dihydrochloride |
Anthelmintic; arsenical compound that kills adult heartworms |
|
Glycine buffer solution |
Maintains pH stability and isotonicity |
|
Sodium hydroxide & HCl |
pH adjustment agents |
Melarsomine dihydrochloride is a trivalent arsenical compound, selectively toxic to adult heartworms, interrupting their energy metabolism.
What Are the Possible Side Effects of Diroban Injection in Dogs?
Dogs may experience mild to moderate side effects post-injection, including:
- Pain or swelling at injection site
- Coughing or gagging
- Depression or lethargy
- Fever
- Loss of appetite
- Pulmonary thromboembolism (a serious complication caused by dying worms)
Seek veterinary attention immediately if symptoms worsen.
Are There Any Warnings or Precautions With Diroban?
Yes, use with caution in the following cases:
- Do not administer to cats
- Contraindicated in dogs with advanced heartworm disease (e.g., caval syndrome)
- Strict cage rest is recommended post-treatment to reduce the risk of embolism
- Not for use in puppies under 4 months
- Dogs should be stabilized and pre-treated with macrocyclic lactones to eliminate microfilariae before Diroban administration
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Diroban Frequently Asked Questions
What is Diroban used for?
Diroban is used to treat heartworm disease in dogs by eliminating immature and mature adult heartworms.
Can Diroban be used in cats?
No, Diroban is formulated specifically for dogs and should not be used in cats.
How long does the treatment process take?
The treatment protocol varies but typically involves multiple injections over a period of 1 to 2 months, followed by a recovery phase with exercise restriction.
Is exercise restriction necessary after treatment?
Yes, limiting activity post-treatment is crucial to prevent complications from dying heartworms.
What should I do if my dog shows side effects after treatment?
Contact your veterinarian promptly to discuss any adverse reactions and receive appropriate care instructions.
Additional Resources
For more information on heartworm disease and treatment options, consider the following reputable sources:
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