{"product_id":"lysodren-mitotane-500mg-tablets","title":"Lysodren (Mitotane) Tablets 500mg (100 tablets) -  Treat Adrenal Cortical Carcinoma","description":"\u003cdiv class=\"rx-map-img\"\u003e\u003cimg src=\"https:\/\/hardypaw.com\/cdn\/shop\/files\/rx-map.webp\" loading=\"lazy\" alt=\"Lysodren (Mitotane) Tablets 500mg (100 tablets) - Treat Adrenal Cortical Carcinoma\" data-original=\"https:\/\/hardypaw.com\/cdn\/shop\/files\/rx-map.webp\" data-files=\"rx-map.webp\"\u003e\u003c\/div\u003e\n\u003ch2\u003eAdrenal Cytotoxic Oral Tablet for Adrenal Cortical Carcinoma\u003c\/h2\u003e\n\u003ch3\u003eProduct Description\u003c\/h3\u003e\n\u003cp\u003eLysodren (Mitotane) Tablets 500 mg is an FDA-approved prescription adrenal cytotoxic agent — each scored white tablet contains 500 mg mitotane along with inactive ingredients microcrystalline cellulose, polyethylene glycol 3350, silicon dioxide, and starch. The FDA-approved label covers treatment of inoperable functional or nonfunctional adrenocortical carcinoma in humans. In veterinary medicine, it is commonly used off-label in dogs to manage pituitary-dependent hyperadrenocorticism (\u003ca href=\"\/collections\/dog-cushings-disease-medications\" title=\"Dog cushing’s disease medications: hormonal balance support | hardypaw\" aria-label=\"Dog cushing’s disease medications: hormonal balance support | hardypaw\"\u003eCushing's disease\u003c\/a\u003e) and adrenal gland carcinoma. It works by directly suppressing adrenal cortex activity and modifying peripheral steroid metabolism, reducing cortisol overproduction. Supplied in bottles of 100 tablets; manufacturer may vary.\u003c\/p\u003e\n\u003ch3\u003eBenefits\u003c\/h3\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eAdrenal Cortex Suppression:\u003c\/b\u003e Directly suppresses adrenal cortex tissue, reducing cortisol production in both functional and nonfunctional adrenocortical carcinoma.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eModifies Peripheral Steroid Metabolism:\u003c\/b\u003e Alters the peripheral metabolism of steroids, causing increased formation of 6-β-hydroxycortisol and reducing 17-hydroxycorticosteroids.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCanine Cushing's Disease Management (Off-Label):\u003c\/b\u003e Destroys the cortisol-producing layers of the adrenal gland in dogs, reducing excess cortisol linked to pituitary-dependent hyperadrenocorticism.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eScored Tablet for Dose Flexibility:\u003c\/b\u003e Each 500 mg tablet is scored to allow splitting when dose adjustments are needed during the initiating or maintenance phase of therapy.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eTwo-Phase Canine Treatment Protocol:\u003c\/b\u003e Veterinary use follows an initiating phase that arrests disease progression, followed by a maintenance phase using the minimum effective dose.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eIngredients\u003c\/h3\u003e\n\u003ch4\u003eActive Ingredients\u003c\/h4\u003e\n\u003cp\u003eMitotane: 500 mg per tablet.\u003c\/p\u003e\n\u003ch4\u003eInactive Ingredients\u003c\/h4\u003e\n\u003cp\u003eMicrocrystalline cellulose, polyethylene glycol 3350, silicon dioxide, starch.\u003c\/p\u003e\n\u003ch3\u003eHow to Use\u003c\/h3\u003e\n\u003ch4\u003eDosage and Administration Instructions\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003ePrescription Required:\u003c\/b\u003e Federal law restricts Lysodren to use by or on the order of a licensed veterinarian; \u003ca href=\"\/collections\/dog-medications\" title=\"Dog medications: allergy, antibiotics, heartworm \u0026amp; more! | hardypaw\" aria-label=\"Dog medications: allergy, antibiotics, heartworm \u0026amp; more! | hardypaw\"\u003enever use without veterinary supervision\u003c\/a\u003e.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eOff-Label Canine Use:\u003c\/b\u003e Lysodren is used off-label in dogs; dosing schedules are determined entirely by the prescribing veterinarian based on the dog's weight and condition.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eInitiating Phase (Dogs):\u003c\/b\u003e Veterinarians typically start at a higher daily dose given in divided doses with food until the disease is arrested and hormone levels normalize.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eMaintenance Phase (Dogs):\u003c\/b\u003e The dose is then stepped down gradually to the lowest amount that keeps the condition controlled, adjusted through regular monitoring.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eGive with High-Fat Food:\u003c\/b\u003e Administering Lysodren alongside a high-fat meal or treat significantly improves mitotane absorption in dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDivided Daily Doses:\u003c\/b\u003e Whether in the initiating or maintenance phase, the total daily amount is split into multiple doses given at evenly spaced intervals throughout the day.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNever Self-Adjust the Dose:\u003c\/b\u003e Dogs respond individually to mitotane; never increase, decrease, or stop dosing without direction from the veterinarian overseeing the treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eRegular Veterinary Monitoring:\u003c\/b\u003e Frequent follow-up visits, bloodwork, and clinical assessments are essential throughout treatment to confirm the dog is on the right dose.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e\u003ci\u003eDisclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.\u003c\/i\u003e\u003c\/p\u003e\n\u003ch3\u003eAdditional Information\u003c\/h3\u003e\n\u003ch4\u003ePrecautions\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eAdrenal Crisis Risk in Shock or Trauma:\u003c\/b\u003e Temporarily stop Lysodren if the dog experiences shock, severe trauma, or serious infection; administer systemic steroids until recovery.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eSteroid Replacement May Be Needed:\u003c\/b\u003e A substantial number of treated patients develop signs of adrenal insufficiency; steroid replacement therapy is sometimes given alongside Lysodren.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAvoid Concurrent Spironolactone:\u003c\/b\u003e Spironolactone is contraindicated with Lysodren, as it may block the drug's adrenal suppressive effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAvoid Concurrent Warfarin:\u003c\/b\u003e Lysodren alters the metabolism of anticoagulants; concurrent warfarin use must be avoided or closely managed with adjusted dosing.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eCNS Toxicity at High Plasma Levels:\u003c\/b\u003e Mitotane plasma levels above 20 mg\/L are associated with significantly higher rates of central nervous system toxicity; regular monitoring is essential.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eProlonged Bleeding Time:\u003c\/b\u003e Prolonged bleeding time has been reported in patients receiving Lysodren; inform the veterinarian of any bleeding concerns during treatment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eEmbryo-Fetal Toxicity:\u003c\/b\u003e Lysodren can cause serious fetal harm; do not use in pregnant animals or allow handling by pregnant women without appropriate protective equipment.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eHandler Safety — Wear Gloves:\u003c\/b\u003e Handlers should wear gloves every time they touch Lysodren tablets; skin contact with mitotane carries absorption risk due to its lipophilic nature.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003ePossible Side Effects\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eLethargy and Sedation:\u003c\/b\u003e Tiredness and sedation are among the most commonly observed effects, particularly when plasma levels are climbing during the initiating phase.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eDigestive Upset:\u003c\/b\u003e Nausea, vomiting, diarrhea, and anorexia are reported frequently; giving Lysodren with a high-fat meal can help reduce gastrointestinal side effects in dogs.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eAdrenal Insufficiency:\u003c\/b\u003e Lysodren can suppress the adrenal gland excessively; signs include weakness, vomiting, and collapse requiring immediate veterinary attention and steroid replacement.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eNeurological Signs:\u003c\/b\u003e Vertigo, dizziness, and cognitive changes including memory impairment have been reported; toxic levels above 20 mg\/L significantly raise the risk of these effects.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eOvarian Macrocysts (Females):\u003c\/b\u003e Lysodren can cause non-malignant multiple bilateral ovarian macrocysts; regular monitoring is recommended for intact females on long-term therapy.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch4\u003eStorage Information\u003c\/h4\u003e\n\u003cul\u003e\n\u003cli\u003e\n\u003cb\u003eControlled Room Temperature:\u003c\/b\u003e Store at 20-25°C (68-77°F); keep away from moisture and direct light, which can degrade the tablets over time.\u003c\/li\u003e\n\u003cli\u003e\n\u003cb\u003eKeep Out of Reach:\u003c\/b\u003e Store in a locked location away from children and all pets; mitotane is a cytotoxic agent that must never be accessible to children or other animals.\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch3\u003eShipping \u0026amp; Return\u003c\/h3\u003e\n\u003cp\u003eWe offer ground, express, and priority delivery; see our \u003ca href=\"\/pages\/shipping-policy\" title=\"Shipping policy\" aria-label=\"Shipping policy\"\u003eshipping policy\u003c\/a\u003e for details.\u003c\/p\u003e\n\u003cp\u003eFor return instructions or product concerns, please refer to our detailed \u003ca href=\"\/policies\/refund-policy\" title=\"Refund policy\" aria-label=\"Refund policy\"\u003erefund policy\u003c\/a\u003e.\u003c\/p\u003e\n\u003cp\u003ePRESCRIPTION ITEMS ARE NON-RETURNABLE AND NON-REFUNDABLE.\u003c\/p\u003e\n\u003ch2\u003eFrequently Asked Questions\u003c\/h2\u003e\n\u003ch3\u003eQ1: What is Lysodren Mitotane used for in dogs?\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eAns:\u003c\/b\u003e Lysodren is used off-label in dogs to manage pituitary-dependent Cushing's disease and adrenal gland carcinoma. It works by destroying the cortisol-producing layers of the adrenal gland, lowering excess cortisol. The FDA-approved indication covers inoperable adrenocortical carcinoma in humans.\u003c\/p\u003e\n\u003ch3\u003eQ2: How is Lysodren mitotane given to dogs with Cushing's disease?\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eAns:\u003c\/b\u003e Treatment follows two stages — an initiating phase where a higher divided daily dose is given with high-fat food until hormone levels normalize, followed by a maintenance phase using the lowest effective dose. The veterinarian determines all dosage changes based on regular monitoring and bloodwork.\u003c\/p\u003e\n\u003ch3\u003eQ3: Why does Lysodren need to be given with a high-fat meal?\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eAns:\u003c\/b\u003e Mitotane is a fat-soluble drug, which means the body takes it up much better when there is some fat in the stomach at the same time. Giving Lysodren alongside a fatty meal or treat helps the dog absorb a full and consistent dose each time, which matters a great deal for keeping treatment on track.\u003c\/p\u003e\n\u003ch3\u003eQ4: What are the signs that a dog on Lysodren has developed adrenal insufficiency?\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eAns:\u003c\/b\u003e Signs of adrenal insufficiency include sudden weakness or collapse, vomiting, loss of appetite, shaking, and disorientation. If any of these appear, stop the medication immediately and contact your veterinarian — emergency steroid replacement therapy may be required. Regular monitoring reduces this risk significantly.\u003c\/p\u003e\n\u003ch3\u003eQ5: Do I need to wear gloves when handling Lysodren mitotane tablets for my dog?\u003c\/h3\u003e\n\u003cp\u003e\u003cb\u003eAns:\u003c\/b\u003e Yes. Lysodren is a cytotoxic drug that gets absorbed through the skin fairly easily, so anyone handling the tablets should put on disposable gloves before touching or splitting them. This is especially important for pregnant women, who should avoid coming into contact with this medication altogether.\u003c\/p\u003e\n\u003ch2\u003eClinical Research\u003c\/h2\u003e\n\u003cp\u003e\u003ca href=\"https:\/\/link.springer.com\/article\/10.1007\/s40267-022-00958-y\" title=\"Client challenge\" aria-label=\"Visit a webpage about Client challenge\"\u003ehttps:\/\/link.springer.com\/article\/10.1007\/s40267-022-00958-y\u003c\/a\u003e\u003c\/p\u003e","brand":"Bristol-Myers Squibb","offers":[{"title":"Default Title","offer_id":43339413815457,"sku":"76336-080-60","price":2200.0,"currency_code":"USD","in_stock":false}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0593\/2446\/5313\/files\/lysodren-mitotane-tablets-500mg-100-tablets-treat-adrenal-963.png?v=1778529041","url":"https:\/\/hardypaw.com\/products\/lysodren-mitotane-500mg-tablets","provider":"HardyPaw","version":"1.0","type":"link"}