Numelvi (atinvicitinib tablets) for Dogs

Once-Daily Itch Relief Tablet for Dogs with Allergic Dermatitis

Product Description

Numelvi (atinvicitinib tablets) is a vet-prescribed oral medication that helps dogs get on top of the itch that comes with allergic dermatitis. It gets to work quickly, bringing noticeable relief in as little as 2 to 4 hours. Given once daily with food around mealtime, dogs and puppies that have crossed the 6-month mark can safely be put on this treatment. Sourced directly from the manufacturer or an approved distributor, every pack is guaranteed authentic.

Benefits

• Acts Fast: Gets absorbed quickly, with allergic itch starting to ease within 2 to 4 hours based on a canine itch model.
• Suitable for Young Dogs: Dogs and puppies that have crossed the 6-month mark can safely be started on this treatment.
• Easy, Once-Daily Dosing: Just one daily dose given with food around mealtime keeps allergic itch under consistent, straightforward control.
• No Interference with Routine Treatments: Works well alongside routine treatments and vaccines, with no meaningful drug interactions flagged during field trials.
• Highly Selective for JAK1: At least 10 times more selective for JAK1 over JAK2, JAK3, and TYK2 in laboratory assays.
• Preserves Immune Function: High JAK1 selectivity minimises interference with the beneficial immune roles of other JAK enzymes.
• Supports Vaccine Response: Dogs on Numelvi demonstrated an adequate immune response to standard canine vaccinations in studies.

Variants

• 4.8 mg tablets
• 7.2 mg tablets
• 21.6 mg tablets
• 31.6 mg tablets

Ingredients

Active Ingredients

Atinvicitinib

How to Use

Dosage & Administration Instructions

• Prescription Required: Numelvi is a prescription-only medication and must be used only under the direction of a licensed veterinarian.
• Once-Daily Oral Dose: Administer orally once daily at 0.36 to 0.54 mg/lb (0.8 to 1.2 mg/kg) body weight as per the dosing table.
• Give With Food: Always administer Numelvi with food at or around mealtime to ensure proper absorption and reduce stomach upset.
• Tablet Size by Weight: Use the tablet strength that matches your dog's body weight as directed in the veterinarian-provided dosing chart.
• Scored Tablets: Each tablet is scored and can be split in half when half-tablet dosing is required for your dog's weight.
• Inform Your Vet: Always tell your veterinarian about all other medicines and supplements your dog is currently receiving before starting Numelvi.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Not for Young Puppies: Numelvi should not be used in dogs younger than 6 months of age under any circumstances.
• Avoid in Serious Infections: Do not administer Numelvi to dogs that are currently suffering from serious active infections.
• Increased Infection Risk: Numelvi may increase susceptibility to opportunistic infections, including demodicosis and interdigital furunculosis; monitor your dog closely during treatment.
• History of Demodicosis: Weigh the risks and benefits carefully before starting treatment in dogs with a history of recurrent demodicosis.
• JAK Inhibitor — Risk of New Growths: Numelvi is a JAK inhibitor; new benign and malignant neoplastic conditions have been reported in dogs treated with other JAK inhibitors; discuss this risk with your veterinarian.
• Limited Field Study Duration: Numelvi's effectiveness and safety beyond 28 days remain unstudied, so loop in your vet for any long-term use decisions.
• Breeding, Pregnant, or Lactating Dogs: How Numelvi affects breeding, pregnant, or nursing dogs has not yet been looked into.
• Immunosuppressive Combinations: Pairing Numelvi with glucocorticoids, cyclosporine, or other immunosuppressive agents has not been studied for safety.

Possible Side Effects

• Vomiting or Nausea: Observed in some dogs during clinical studies; monitor your dog after each dose if this occurs.
• Digestive Upset: Flatulence, retching, bloating, anorexia, and diarrhea were among the gastrointestinal effects reported in the field study.
• Ear Infections: Otitis externa was noted in a small number of dogs treated with Numelvi during clinical trials.
• Urinary Changes: Hematuria, crystalluria, increased urination, and urinary tract infections were reported in some treated dogs.
• Blood Work Changes: Some dogs showed abnormal results including leukopenia, neutropenia, and elevated liver enzymes such as ALT and AST.
• Neurological Signs: Tremors and ataxia were observed in a small number of dogs; consult your vet immediately if these signs appear.

Storage Information

• Room Temperature Storage: Store Numelvi tablets at 15 to 30°C (59 to 86°F) to maintain product integrity and effectiveness.
• Keep Away from Pets: Always store in a secure, closed location well out of reach of dogs and other household animals.
• Keep Away from Children: This is a prescription veterinary drug; store it safely away from children at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is Numelvi used for in dogs?

Ans: Numelvi (atinvicitinib tablets) is a prescription oral tablet used to control itching caused by allergic dermatitis, including atopic dermatitis, in dogs six months of age and older weighing at least 2 kg.

Q2: How does this atinvicitinib itch tablet work for dogs?

Ans: Numelvi works by selectively blocking JAK1, the main enzyme responsible for triggering itch and inflammation in allergic skin conditions. Its high selectivity helps preserve the dog's broader immune function while reducing pruritus.

Q3: How quickly does Numelvi start working in dogs?

Ans: Numelvi starts relieving allergic itch within 2 to 4 hours after dosing, based on a canine interleukin-31-induced pruritus model study. Results in individual dogs may vary; always follow your veterinarian's guidance.

Q4: How often should I give my dog the Numelvi itch relief tablet?

Ans: Numelvi is administered once daily by mouth with food at or around mealtime. The correct tablet strength and dose are determined by your dog's body weight, and your veterinarian will provide a personalised dosing chart for your pet.

Q5: What sizes does the Numelvi dog allergy tablet come in?

Ans: Numelvi is available in four scored tablet strengths: 4.8 mg, 7.2 mg, 21.6 mg, and 31.6 mg. Each strength is marked with S, M, L, or XL and is available in 30 or 90 count bottles.

References

Based on a canine interleukin-31 (cIL-31) itch model, no meaningful drug interactions were picked up during a 28-day field trial in dogs with allergic dermatitis. This covered use alongside antimicrobials including topicals, ecto- and endoparasiticides such as isoxazolines, milbemycins, avermectins, pyrethrins, and pyrethroids, as well as analgesics, anesthetics, nutritional supplements, non-glucocorticoid topical skin and ear cleansers, and medicated shampoos.

1. Kowalski T, Prohaczik A, Locke K, et al. The second-generation Janus kinase inhibitor atinvicitinib significantly reduces pruritus 2-4 hours after dosing dogs in a canine interleukin-31 model. Vet Dermatol. 2026;0:17-18. https://doi.org/10.1111/vde.70046

2. Data on File. Study Summary REF-11196. Merck Animal Health