Panoquell-CA1 for Dogs
PANOQUELL -CA1 (fuzapladib sodium injection) is the first FDA-conditionally approved treatment for managing clinical signs associated with the acute onset of pancreatitis in dogs.
It is a fast, safe, and effective treatment for controlling the inflammation associated with acute canine pancreatitis (ACP) LFA-1 activation inhibitor Inhibits the infiltration of neutrophilic inflammation within the pancreas.
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It is given once daily for 3 consecutive days by IV bolus injection.
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It is proven to quickly reduce clinical signs and measurable values such as canine pancreas-specific lipase (Spec cpL) and C-reactive protein (CRP) associated with ACP.
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It can be given in conjunction with other supportive care treatments.
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For intravenous use in dogs only.
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PANOQUELL can reduce time and stress often seen in the hospital setting with ACP treatment.
Benefits of Using Panoquell-CA1
- Rapid Onset of Action: Panoquell-CA1 provides fast relief by quickly reducing inflammation and pain in dogs with acute pancreatitis.
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Ease of Administration: The injectable form allows for precise dosing and direct administration, ensuring effective delivery.
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Specific Health Improvements: Clinical trials have shown significant health benefits, including reduced inflammation and faster recovery times.
- Veterinary Benefits: Its targeted action on inflammatory pathways minimizes side effects and maximizes therapeutic effects.
- Clinical Outcomes: Positive clinical outcomes highlight its effectiveness in managing acute pancreatitis, promoting quicker recovery and better health.
Ingredients
Each vial contains 14mg of Fuzapladib Sodium, providing a concentration of 4mg/mL when reconstituted. This precise formulation ensures consistent therapeutic effects.
Recommended Dosage
Use as directed by your veterinarian.
PANOQUELL-CA1 is a 4 mg/mL solution when reconstituted. It comes in a multi-use vial. Once reconstituted, it remains stable under refrigeration for 28 days.
PANOQUELL-CA1 consists of two separate vials:
- One vial contains 14 mg of fuzapladib sodium, 52.5 mg of D-mannitol, and 21 mg of tromethamine as sterile lyophilized powder.
- The second vial of 3.9 mL sterile diluent (bacteriostatic water for injection), containing 1.8% w/v benzyl alcohol, is for reconstituting the sterile lyophilized powder before use.
No other diluent should be used.
PANOQUELL-CA1 is an intravenous (IV) injection dosed once a day for 3 days. The IV injection can be given over 15 seconds to 1 minute as a bolus.
Administration
Dosage Determination: Based on the pet’s weight, medical history, and other pertinent information, the veterinarian will establish the right dosage of Panoquell-CA1.
Injection Site: An intravenous (IV) injection of panoquell-CA1 is given. The veterinarian will use a sterile IV catheter to choose an appropriate vein for the injection.
Injection Procedure: The drug is delivered into the vein slowly and directly throughout the injection process. The injection rate will be regulated to guarantee the patient's security and well-being.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Possible Side Effects of Panoquell-CA1
In the pilot field effectiveness study, PANOQUELL-CA1 was administered safely with other supportive care treatments including anti-emetics and pain control. The most common adverse reactions included:
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Anorexia,
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Digestive Tract Disorders,
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Respiratory Tract Disorders
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Hepatopathy And
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Jaundice.
Storage Instructions
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Store unopened vials at room temperature, 59° to 77°F (15° to 25°C).
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Store the reconstituted product at refrigerated conditions, 36° to 46°F (2° to 8°C).
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Use within 28 days of the first puncture.
FAQs - Panoquell for Dogs
1. What is Panoquell-CA1 used for?
2. How is Panoquell-CA1 administered?
3. Is Panoquell-CA1 safe for all dogs?
The medication is generally safe when used as directed by a veterinarian. It is specifically designed for dogs with acute pancreatitis. Always consult with a veterinarian before starting treatment.
4. How often should Panoquell-CA1 be administered?
5. Can Panoquell-CA1 be used for long-term treatment?
References:
- https://www.ceva.us/News-Media/News-Releases-Articles-About-Ceva/PANOQUELL-R-CA1-fuzapladib-sodium-for-injection-is-now-available-in-the-U.S
- https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=e2e316bd-ff8b-4d14-a2e8-c518f8b153cb&type=display
- https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/13134
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