Tildren 500mg (30 mL) for Horses

Tildren 500mg (30 mL) for Horses

Tildren belongs to a class of drugs called bisphophonates.Bisphophonates prevent the loss of bone mass and are used in humans to inhibit bone resorption by blocking activity of osteoclasts, to increase bone density and to inhibit secretion of enzymes that degrade cartilage on joint surfaces. In horses, Tildren is used to treat navicular syndrome, hock disease (spavin) and kissing spine syndrome. Some veterinarians see the drug as a new avenue to manage diseases that are characterized by circumstances in which the bone breakdown process exceeds the bone rebuilding process.

If bone loss can be limited during the inflammatory and degenerative processes, it is thought that a positive effect on bone structure and reduction of pain are possible. In a horse with navicular or other chronic bone conditions, such as ringbone, for example, or osteoarthritis of the hock, Tildren acts to inhibit bone deconstruction by shutting down what are known as osteoclasts. Osteoclasts are like hungry termites that digest bone, and Tildren impedes this process. By reducing bone breakdown and further degeneration, the drug reduces pain, which in many cases contributes to lameness. Following IV infusion, Tildren® travels systemically and binds to the mineral matrix of the bone. The acidity of the remodeling environment causes the release of Tildren® from the bone matrix into the resorption space. This leads to improved bone remodeling, decreased mineral loss, and alleviation of pain induced by abnormal osteolysis.

Recommended Dosage

Use as directed by your veterinarian. This medication is administered via intravenous infusions. 

Storage Instructions

Store at controlled room temperature 68°F-77°F (20°C-25°C). After preparation, the infusion should be administered either within 2 hours of preparation, or it can be stored for up to 24 hours under refrigeration at 36°F-46° F (2°C-8°C) and protected from light.

All prescription items are Non-Refundable and Non-Returnable.