Revolt Topical Solution for Dogs
Revolt (selamectin) is a prescription monthly topical parasiticide for dogs or puppies six weeks and older. Revolt kills adult fleas and prevents flea eggs from hatching for one month and is indicated for the prevention and control of flea infestations (Ctenocephalides felis), prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite (Otodectes cynotis) infestations. Revolt is also indicated for the treatment and control of sarcoptic mange (Sarcoptes scabiei) and the control of tick infestations due to Dermacentor variabilis.
- Revolt eliminates adult fleas, prevents and controls flea infestations, and also targets flea eggs.
- Revolt acts as a preventative measure against heartworm disease and is effective in eliminating the American dog tick.
- It manages and regulates infections caused by ear mites.
- It manages and regulates sarcoptic mange.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.
Dosage and Administration:
The recommended minimum dose is 2.7 mg of selamectin per pound (6 mg/kg) of body weight.
Administer the entire contents of a single dose tube (or two tubes used in combination for dogs weighing over 130 pounds) of Revolt topically per the following tables. (See ADMINISTRATION for the recommended treatment intervals.)
Cats (lb) | Package Color | mg per tube | Potency (mg/mL) | Administere d volume (mL) |
---|---|---|---|---|
Up to 5 | Rose | 15 mg | 60 | 0.25 |
5.1-15 | Blue | 45 mg | 60 | 0.75 |
15.1-22 | Taupe | 60 mg | 60 | 1.0 |
For cats over 22 lbs use the appropriate combination of tubes.
Dogs (lb) | Package Color | mg per tube | Potency (mg/mL) | Administere d volume (mL) |
---|---|---|---|---|
Up to 5 | Rose | 15 mg | 60 | 0.25 |
5.1-10 | Purple | 30 mg | 120 | 0.25 |
10.1-20 | Brown | 60 mg | 120 | 0.5 |
20.1-40 | Maroon | 120 mg | 120 | 1.0 |
40.1-85 | Teal | 240 mg | 120 | 2.0 |
85.1-130 | Plum | 360 mg | 120 | 3.0 |
For dogs over 130 lbs use the appropriate combination of tubes. Recommended for use in dogs 6 weeks of age and older and in cats 8 weeks of age and older.
Administration:
A veterinarian or veterinary technician should demonstrate or instruct the pet owner regarding the appropriate technique for applying Revolt topically to dogs and cats before first use.
While holding the tube in an upright position, twist the cap to break the seal. The cap will remain on the tube. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly onto the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift it to remove. Check the tube to ensure that it is empty.
Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the haircoat is wet. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolt against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolt against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Revolt against heartworm.
Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some animals. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.
Flea Control in Dogs and Cats
For the prevention and control of flea infestations, Revolt should be administered at monthly intervals throughout the flea season, starting one month before fleas become active. In controlled laboratory studies ›98% of fleas were killed within 36 hours. Results of clinical field studies using selamectin monthly demonstrated ›90% control of flea infestations within 30 days of the first dose. Dogs and cats treated with selamectin, including those with pre-existing flea allergy dermatitis, showed improvement in clinical signs associated with fleas as a direct result of eliminating the fleas from the animals and their environment.
If the dog or cat is already infested with fleas when the first dose of Revolt is administered, adult fleas on the animal are killed and no viable fleas hatch from eggs after the first administration. However, an environmental infestation of fleas may persist for a short time after beginning treatment with Revolt because of the emergence of adult fleas from pupae.
Heartworm Prevention in Dogs and Cats
For the prevention of heartworm disease, Revolt must be administered every month. Revolt may be administered year-round or at least within one month after the animal’s first exposure to mosquitoes and monthly thereafter until the end of the mosquito season. The final dose must be given within one month after the last exposure to mosquitoes. If a dose is missed and a monthly interval between dosing is exceeded then immediate administration of Revolt and resumption of monthly dosing will minimize the opportunity for the development of adult heartworms. When replacing another heartworm preventive product in a heartworm disease prevention program, the first dose of Revolt must be given within a month of the last dose of the former medication.
Selamectin, the active ingredient in Revolt, is a macrocyclic lactone compound. These compounds effectively prevent the development of adult heartworms when administered to dogs and cats within one month of exposure to infective (L3) Dirofilaria immitis larvae. Efficacy of macrocyclic lactones decreases below 100% in dogs, however, if first administered ›2 months after exposure to infective larvae. Thus, in heartworm endemic regions, delaying initiation of heartworm prevention using Revolt beyond 2 months of first exposure to infective larvae (e.g., starting puppies and kittens at ›8 weeks of age), or gaps of ›2 months in the administration of Revolt during periods of heartworm transmission, increases the risk of the animal acquiring heartworms. Animals with unknown heartworm history that test negative for heartworms before the initiation of Revolt may be harboring pre-patent infections at the time Revolt was started. Testing such animals 3-4 months after initiation of Revolt would be necessary to confirm their negative heartworm status.
At the discretion of the veterinarian, cats ≥ 6 months of age may be tested to determine the presence of existing heartworm infections before beginning treatment with Revolt. Cats already infected with adult heartworms can be given Revolt monthly to prevent further infections.
Ear Mite Treatment in Dogs and Cats
For the treatment of ear mite (O. cynotis) infestations in dogs and cats, Revolt should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolt will control any subsequent ear mite infestations. In the clinical field trials, ears were not cleaned, and many animals still had debris in their ears after the second dose. Cleansing of the infested ears is recommended to remove the debris.
Sarcoptic Mange Treatment in Dogs
For the treatment of sarcoptic mange (S. scabiei) in dogs, Revolt should be administered once as a single topical dose. A second monthly dose may be required in some dogs. Monthly use of Revolt will control any subsequent sarcoptic mange mite infestations. Because of the difficulty in finding sarcoptic mange mites on skin scrapings, effectiveness assessments also were based on a resolution of clinical signs. Resolution of the pruritus associated with the mite infestations was observed in approximately 50% of the dogs 30 days after the first treatment and in approximately 90% of the dogs 30 days after the second monthly treatment.
Tick Control in Dogs
For the control of tick (Dermacentor variabilis) infestations in dogs, Revolt should be administered every month. In heavy tick infestations, complete efficacy may not be achieved after the first dose. In these cases, one additional dose may be administered two weeks after the previous dose, with monthly dosing continued thereafter.
Nematode Treatment in Cats
For the treatment and control of intestinal hookworm (A. tubaeforme) and roundworm (T. cati) infections, Revolt should be applied once as a single topical dose.
WARNINGS:
User Safety Warnings
Not for human use. Keep out of the reach of children. In humans, Revolt may be irritating to skin and eyes.
Reactions such as hives, itching, and skin redness have been reported in humans in rare instances. Individuals with known hypersensitivity to Revolt should use the product with caution or consult a health care professional. Revolt contains isopropyl alcohol and the preservative butylated hydroxytoluene (BHT). Wash hands after use and wash off any product in contact with the skin immediately with soap and water. If contact with eyes occurs, then flush eyes copiously with water; if wearing contact lenses, rinse eyes first then remove contact lenses and continue to rinse for 5-10 minutes and seek medical attention. In case of ingestion by a human, contact a physician immediately. The safety data sheet (SDS) provides more detailed occupational safety information.
Flammable - Keep away from heat, sparks, open flames, or other sources of ignition.
Animal Safety Warnings
Do not use in sick, debilitated or underweight animals.
PRECAUTIONS:
Before administration of Revolt, dogs should be tested for existing heartworm infections. At the discretion of the veterinarian, infected dogs should be treated to remove adult heartworms. Revolt is not effective against adult D. immitis and, while the number of circulating microfilariae may decrease following treatment, Revolt is not effective for microfilariae clearance.
Hypersensitivity reactions have not been observed in dogs with patent heartworm infections administered selamectin.
STORAGE CONDITIONS:
Store below 30°C (86°F).
FAQ
- Why has my veterinarian prescribed Revolt?
- Revolt has been prescribed by your veterinarian to treat, prevent, and/or control the following parasites in your dog or cat:
Dog Parasites:
- Control and prevention of flea infestation (Ctenocephalides felis)
- Prevention of heartworm disease (Dirofilaria immitis)
- Treatment and control of ear mite infestation (Otodectes cynotis)
- Treatment and control of sarcoptic mange (Sarcoptes scabiei)
- Control of the American Dog Tick (Dermacentor variabilis)
Cat Parasites:
- Control and prevention of flea infestation (Ctenocephalides felis)
- Prevention of heartworm disease (Dirofilaria immitis)
- Treatment and control of ear mite infestation (Otodectes cynotis)
- Treatment and control of intestinal worms - Roundworm (Toxocara cati), Hookworm (Ancylostoma tubaeforme)
- What should I discuss with my veterinarian before Revolt is prescribed?
- Your veterinarian is best suited to discuss and recommend appropriate medications for your dog or cat. It is important to discuss your pet’s health history with your veterinarian so he/she can decide if Revolt is right for your animal.
- Revolt should not be used in sick, debilitated, or underweight animals.
- Dogs should be tested for heartworm disease before giving Revolt. If your dog tests positive for adult heartworms, your veterinarian can recommend appropriate treatment. Dogs infected with adult heartworms can safely be given Revolt.
- If your cat is older than six months of age, your veterinarian may decide to test him/her for heartworm disease before prescribing Revolt. Cats infected with adult heartworms can be given Revolt to prevent further infections.
- What dose of Revolt do I use on my dog or cat?
- Your veterinarian will recommend the appropriate dose for your dog or cat based on your animal’s body weight. You should not administer Revolt to dogs younger than 6 weeks of age or cats younger than 8 weeks of age. Revolt is available in eight separate dose strengths for dogs and cats of different weights.
- What should I do if I do not give Revolt on time or miss a dose?
- If you forget to apply a monthly dose of Revolt, immediately apply Revolt, resume monthly applications, and notify your veterinarian.
- Can I bath my pet after applying Revolt?
- Yes. Bathing or shampooing the dog 2 or more hours after treatment will not reduce the effectiveness of Revolt against fleas or heartworm. Bathing or shampooing the cat 2 hours after treatment will not reduce the effectiveness of Revolt against fleas. Bathing or shampooing the cat 24 hours after treatment will not reduce the effectiveness of Revolt against heartworm.
- Can Revolt be given with other medicines?
- In well-controlled clinical studies, selamectin was used safely in dogs and cats receiving other veterinary products such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, collars, shampoos, and dips.
- Tell your veterinarian about all medicines you have given your dog or cat in the past and any medicines that you are planning to use with Revolt. This should include other medicines that you can get without a prescription. Your veterinarian may want to check that all of your dog’s or cat’s medicines can be given together.
Recommended for the Revolt Topical Solution for Dogs, 10.1-20 lbs, (Brown Box)
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