Simparica Trio for Dogs (Sarolaner, Moxidectin, and Pyrantel) 44.1-88 lbs - Complete Protection

Simparica Trio for Dogs 44.1-88 lbs

Simparica Trio is an innovative and highly effective solution designed for dogs weighing 44.1-88 lbs. Manufactured by Zoetis, a leader in animal health, this chewable tablet provides comprehensive protection against three major parasites: fleas, ticks, and heartworms.

The convenience of a once-monthly dose ensures that pet owners can easily manage their pet's health with minimal hassle, making it a preferred choice among veterinarians and pet owners alike.

Simparica Trio is designed with palatability in mind. The chewable tablets are flavored, making them more appealing to dogs, which simplifies the administration process for pet owners.

This product's ability to provide broad-spectrum protection in a single, tasty tablet every month enhances the dogs life quality and offers peace of mind to their owners, knowing their pets are well-protected.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Simparica Trio - Ingredients and How Does It Work?

This advanced formula combines three active ingredients—Sarolaner, Moxidectin, and Pyrantel—which work synergistically to prevent flea infestations, control tick populations, and protect against heartworm disease. 

• Sarolaner quickly eliminates adult fleas before they can lay eggs, thereby breaking the flea life cycle. 
• Moxidectin is effective in preventing heartworm disease by killing the larvae transmitted by mosquitoes.
• Pyrantel combats intestinal parasites such as roundworms and hookworms, ensuring your dog is protected from a broad spectrum of internal and external threats.

How Quickly Does Simparica Trio Start Working?

Simparica Trio starts working quickly after ingestion. It begins killing fleas within 4 hours and ticks within 8 hours. This rapid action ensures that dogs receive prompt relief from these parasites shortly after the medication is administered

Benefits of Simparica Trio

• Triple-Action Protection: Prevents flea infestations, controls tick populations and protects against heartworm disease.
• Ease of Administration: The chewable tablets are easy to administer and palatable, ensuring your dog takes them without fuss.
• Long-Lasting Effectiveness: Provides month-long protection, ensuring your dog remains safeguarded between doses.

In studies, Simparica Trio demonstrated:

• 98.9% efficacy against 5 major tick species
• 100% efficacy against fleas within 8 hours of treatment
• 99.2% efficacy against adult roundworms
• 94% efficacy against hookworms
  

Simparica Trio is highly palatable, with 91.9% of dogs consuming it voluntarily with or without food. It protects 2-3 parasiticides in a single chewable, making it a convenient choice for pet owners.

Heartworm Prevention

SIMPARICA TRIO should be administered at monthly intervals all around the year or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure.

If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.

Flea Treatment and Prevention

Treatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active.

To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.

Tick Treatment and Control

Treatment with SIMPARICA TRIO can begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before ticks become active.

Intestinal Nematode Treatment and Control

For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections,

SIMPARICA TRIO should be administered once as a single dose. Monthly use of SIMPARICA TRIO will control any subsequent infections.

Dosage and Administration

SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

SIMPARICA TRIO can be offered to the dog with or without food.

Contraindications:

There are no known contraindications for the use of SIMPARICA TRIO.

Warnings:

Not for use in humans. Keep this and all drugs out of reach of children.

Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.

Safety Information and Side Effects

Simparica Trio is generally considered safe for dogs; however, there are important safety considerations and potential side effects to be aware of.

Safety Information

• Caution for Certain Dogs: Use Simparica Trio with caution in dogs with a history of seizures or neurological disorders. The product contains sarolaner, which belongs to the isoxazoline class of drugs, associated with neurologic signs such as tremors, ataxia, and seizures in some dogs, even those without prior seizure history.

• Heartworm Testing: Dogs should be tested for existing heartworm infections before administering Simparica Trio. Infected dogs should be treated with an adulticide to eliminate adult heartworms, as Simparica Trio is not effective against adult Dirofilaria immitis.

• Pregnancy and Lactation: The safety of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs.

Side Effects of Simparica Trio

• Vomiting
• Diarrhea
• Lethargy
• Anorexia
• Polyuria
• Hyperactivity
• Polydipsia

These reactions were generally mild and resolved without treatment. In studies, diarrhea was frequently noted, particularly in dogs treated for fleas and roundworms.

Shipping & Returns 

• Shipping Policy: We offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.
• Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.
  

FAQs Related to Simparica Trio

1. How is Simparica Trio different from other preventatives?

Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, 5 types of ticks, fleas, roundworms, and hookworms, all in only one monthly chewable.

2. Is Simparica Trio safe?

Simparica Trio is safe for dogs as young as 8 weeks old, and weighing as little as 2.8 lbs.

3. How often do you give Simparica Trio?

Simparica trio chewables are given once a month unless otherwise directed by your vet. 

4. How do I switch from another heartworm medication or tick and flea medication?

Talk to your vet today to see if Simparica Trio is right for your dog. Hardy Paw offers a bunch of heartworm & flea and tick medications if Simparica Trio isn't the one for your dog.  Click on the links below to explore more: 

• Flea & Tick Medication (hardypaw.com)
• Heartworm Preventives (hardypaw.com)
  

5. Do I need a prescription for Simparica Trio?

Yes, your vet can prescribe the correct dose for your dog. 

6. What if I’m late giving a Simparica Trio dose?

Give a new dose as soon as you realize you missed one. Also, give a new dose if your dog vomits or spits out the chew. Then, continue on the prescribed monthly dosing schedule. 

7. How fast does Simparica Trio work to kill ticks and fleas?

Simparica Trio starts killing ticks within 8 hours and fleas within 4 hours. These chews reach their maximum effectiveness within 24 hours of administration. 

8. When can I start Simparica Trio for a puppy?

You can begin using Simparica Trio with puppies as young as 8 weeks old weighing at least 2.8 lbs.

9. Can Simparica Trio help to prevent Lyme infections?

Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing deer ticks.

10.  How should I store Simparica Trio to ensure its effectiveness?

To ensure the effectiveness of Simparica Trio, it should be stored properly. Here are the key storage guidelines:

• Temperature: Store Simparica Trio at or below 30°C (86°F). Brief exposure to temperatures up to 40°C (104°F) is acceptable, but prolonged exposure should be avoided.
• Packaging: Keep the medication in its original blister pack until ready to use. This helps protect it from moisture and light.
• Location: Store the product in a cool, dry place, away from direct sunlight. Ensure it is kept out of reach of children and pets to prevent accidental ingestion or overdose.

Following these storage instructions will help maintain the medication's efficacy and safety.