Simparica Trio for Puppies (Sarolaner, Moxidectin, and Pyrantel) 2.8-5.5 lbs

Simparica Trio Chews for Puppies 2.8-5.5 lbs

Complete Flea, Tick & Heartworm Protection

Simparica Trio Chews for Puppies 2.8-5.5 lbs is a veterinarian-recommended, FDA-approved chewable tablet designed to provide broad-spectrum parasite protection for small breed puppies. This once-monthly liver-flavored chew offers triple defense against fleas, ticks, heartworms, roundworms, and hookworms, ensuring your young pup stays protected during its critical developmental stage.

Manufactured by Zoetis, Simparica Trio is formulated with Sarolaner, Moxidectin, and Pyrantel Pamoate—three powerful active ingredients that work synergistically to provide fast-acting and long-lasting parasite control. With just one chew per month, this easy-to-administer preventative helps safeguard your puppy from both internal and external parasites, ensuring a healthy start in life.

Also Available In:

Simparica Trio is available in different dosage strengths to ensure optimal protection for dogs of all sizes. Find the perfect dose for your furry friend:

✅ Simparica Trio Chewable Tablets for Dogs 5.6-11.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 11.1-22.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 22.1-44.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 44.1-88.0 lbs
✅ Simparica Trio Chewable Tablets for Dogs 88.1-132.0 lbs

Ensure your dog gets the right dosage for their size and weight to receive full-spectrum parasite protection. 🐶💙

Why Choose Simparica Trio Chews for Puppies 2.8-5.5 lbs?

✔ Triple-Action Parasite Protection – Prevents heartworm disease, eliminates fleas & ticks, and treats intestinal worms.
✔ Fast-Acting & Long-Lasting – Kills fleas within 4 hours and ticks within 8 hours, ensuring 30-day continuous protection.
✔ Vet-Approved & Safe for Puppies – Can be used in puppies as young as 8 weeks old, with a proven high safety margin.
✔ Easy, Tasty Chewable – Liver-flavored formulation ensures high palatability for stress-free dosing.
✔ Clinically Proven Efficacy – Effective against 5 tick species, fleas, roundworms, and hookworms.

Clinically Proven Effectiveness

How Do Simparica Trio Chews for Puppies 2.8-5.5 lbs Work?

Simparica Trio delivers comprehensive parasite control using three scientifically proven active ingredients:

• Sarolaner (Isoxazoline-class ectoparasiticide) – Eliminates fleas before they lay eggs, disrupting the flea life cycle, and kills 5 species of ticks, reducing the risk of Lyme disease, Ehrlichiosis, and Anaplasmosis.
• Moxidectin (Macrocyclic lactone endoparasiticide) – Prevents Dirofilaria immitis (heartworm larvae) from maturing into adult heartworms, which can cause serious cardiopulmonary disease.
• Pyrantel Pamoate (Tetrahydropyrimidine-class anthelmintic) – Targets intestinal nematodes, including roundworms and hookworms, preventing digestive issues, malnutrition, and anemia.

This single chewable tablet provides broad-spectrum protection, ensuring puppies receive essential parasite defense during their critical growth phase.

How to Use Simparica Trio Chews for Puppies 2.8-5.5 lbs?

Recommended Dosage

• Give once a month as prescribed by your veterinarian.
• Can be administered with or without food.
• If a dose is missed, give it immediately and resume the monthly schedule.

Why Is Year-Round Protection Important for Puppies?

Heartworm Prevention

• Protects against Dirofilaria immitis, a mosquito-borne parasite that can cause fatal heartworm disease.
• Puppies should be tested for heartworm infection before starting Simparica Trio.

Flea Control & Prevention

• Eliminates adult fleas (Ctenocephalides felis) before they reproduce, preventing flea infestations.
• Provides continuous flea protection for 30 days, reducing the risk of flea allergy dermatitis (FAD).

Tick Treatment & Prevention

Kills 5 major tick species, including:

• Deer ticks (Ixodes scapularis) – Carriers of Lyme disease.
• Lone Star ticks (Amblyomma americanum) – Vectors of Ehrlichiosis.
• American dog ticks (Dermacentor variabilis) – Linked to Rocky Mountain spotted fever.
• Gulf Coast ticks (Amblyomma maculatum) – Associated with Hepatozoonosis.
• Brown dog ticks (Rhipicephalus sanguineus) – Transmitters of Babesiosis and Ehrlichiosis.

Roundworm & Hookworm Treatment

• Treats Toxocara canis (roundworms), which can cause digestive distress and developmental issues in puppies.
• Eliminates Ancylostoma caninum (hookworms), a parasite that can lead to anemia and weight loss in young dogs.

Is Simparica Trio Chews Safe for Puppies ? (Side Effects & Warnings)

Simparica Trio is safe for puppies 8 weeks and older, weighing at least 2.8 lbs. However, mild side effects may occur in some cases.

Possible Side Effects:

• Vomiting
• Diarrhea
• Lethargy
• Loss of appetite
• Increased thirst or urination
• Muscle tremors (rare)

Warnings & Precautions:

⚠ Use with caution in puppies with a history of seizures or neurological disorders.
⚠ Not recommended for breeding, pregnant, or lactating dogs (safety not evaluated).
⚠ Keep out of reach of children and other pets to prevent accidental ingestion.

Shipping & Returns 

Shipping Policy: We offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Simparica Trio Chews for Puppies 2.8-5.5 lbs FAQs

1. What are Simparica Trio Chews for Puppies 2.8-5.5 lbs used for?

Simparica Trio is a monthly chewable tablet that protects puppies 2.8-5.5 lbs from fleas, ticks, heartworms, roundworms, and hookworms.

2. How quickly does Simparica Trio start working?

Simparica Trio begins killing fleas within 4 hours and ticks within 8 hours after administration.

3. Can Simparica Trio be given with food?

Yes, it can be given with or without food, and most puppies enjoy its liver-flavored taste.

4. Does Simparica Trio prevent Lyme disease?

Yes! By eliminating deer ticks, Simparica Trio helps reduce the risk of Lyme disease transmission.

5. What if I miss a dose?

Administer the missed dose immediately, then continue with the regular monthly schedule. If unsure, consult your veterinarian.