Cardalis Chewable Tablets for Dogs (Spironolactone/Benazepril Hydrochloride) - 20mg/2.5mg

Dual-Action Congestive Heart Failure Support for Dogs

Product Description

Cardalis (20 mg spironolactone / 2.5 mg benazepril hydrochloride) is a flavored chewable tablet formulated for dogs with congestive heart failure caused by atrioventricular valvular insufficiency. It combines spironolactone and benazepril hydrochloride to target the renin-angiotensin-aldosterone system at multiple levels. Used alongside therapies such as furosemide, it helps manage clinical signs of mild, moderate, and severe heart failure with once daily, weight-based dosing.

Benefits

• Dual RAAS Blockade: Combines spironolactone and benazepril to inhibit both ACE and non-ACE aldosterone pathways.
• Proven Clinical Effectiveness: Demonstrated statistically lower treatment failure rates compared to benazepril alone in a 360-day study.
• Extended Time-to-Failure: Dogs treated with Cardalis showed a longer median time-to-treatment failure versus the control group.
• Once Daily Dosing: Administered orally once daily with food using scored tablets for accurate weight-based dosing.
• High Palatability: Voluntarily accepted in 87.6 percent of administered doses during field study evaluation.
• Concurrent Therapy Compatible: Safely administered alongside furosemide, digoxin, calcium channel blockers, and other supportive treatments.

Variants

• 20 mg spironolactone / 2.5 mg benazepril hydrochloride chewable tablets
• 40 mg spironolactone / 5 mg benazepril hydrochloride chewable tablets
• 80 mg spironolactone / 10 mg benazepril hydrochloride chewable tablets

Ingredients

Composition Table

How to Use

Dosage & Administration Instructions

• Stabilize Pulmonary Edema: Begin treatment only after pulmonary edema has been properly stabilized.
• Weight-Based Dosing: Administer 2 mg/kg spironolactone and 0.25 mg/kg benazepril hydrochloride once daily, equivalent to 0.9 mg/lb and 0.11 mg/lb, respectively.
• Oral Administration: Give tablets orally using an appropriate combination of whole or half-scored tablets.
• Administer With Food: Always provide Cardalis with food to ensure consistent absorption of spironolactone.
• Prescription Required: Federal law restricts this medication to use by or on order of a licensed veterinarian.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Monitor Potassium Levels: Evaluate renal function and serum potassium before and during treatment due to hyperkalemia risk.
• NSAID Caution: Avoid concurrent NSAIDs in dogs with renal insufficiency to reduce renal toxicity risk.
• Hepatic Dysfunction: Use carefully in dogs with liver impairment due to extensive hepatic biotransformation.
• Digoxin Interaction: Monitor closely when combined with digoxin, as spironolactone may increase digoxin plasma concentrations.
• Not Evaluated Groups: Safety not established in pregnant, lactating, breeding, or growing dogs.

Possible Side Effects

• Loss of Appetite: Some dogs showed a reduced appetite during the 360 day clinical study.
• Vomiting: Vomiting was reported in dogs that received the treatment.
• Low Energy: A few dogs seemed less active than usual during the treatment period.
• Diarrhea: Some dogs experienced stomach upset, including diarrhea.
• Kidney Concerns: Kidney issues were reported more often compared to dogs treated with benazepril alone.
• Higher Potassium Levels: Potassium levels were higher in treated dogs, but they still stayed within the normal range.

Storage Information

• Storage Temperature: Keep the tablets at room temperature, between 20°C and 25°C.
• Short-Term Changes: Brief temperature changes between 15°C and 30°C are acceptable if needed.
• Keep in Original Packaging: Store the tablets in their original container to help maintain their stability and quality.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is Cardalis 20 mg/2.5 mg used for in dogs?

Ans: Cardalis 20 mg spironolactone and 2.5 mg benazepril hydrochloride tablets are used to help manage the signs of mild, moderate, or severe congestive heart failure in dogs caused by atrioventricular valve disease. They are typically given along with other treatments, such as furosemide, as part of a complete care plan.

Q2: What strengths are in the Cardalis 20 mg/2.5 mg tablet?

Ans: Each flavored, scored chewable tablet contains 20 mg of spironolactone and 2.5 mg of benazepril hydrochloride in a fixed 8:1 ratio. Tablets are designed for accurate weight-based dosing using whole or half-tablet increments.

Q3: How should Cardalis 20 mg/2.5 mg be administered?

Ans: Cardalis 20 mg/2.5 mg tablets should be given orally once daily at 2 mg/kg spironolactone and 0.25 mg/kg benazepril hydrochloride. Dosing must begin after pulmonary edema is stabilized, and tablets should always be administered with food.

Q4: Is Cardalis proven effective compared to benazepril alone?

Ans: In a 360-day U.S. field study involving 569 dogs, Cardalis demonstrated a statistically significant lower treatment failure rate compared to benazepril alone. Dogs treated with Cardalis also showed a longer median time-to-treatment failure.

Q5: What side effects were reported with Cardalis?

Ans: In a 360 day U.S. field study, the most commonly reported side effects were loss of appetite, vomiting, tiredness, diarrhea, and kidney problems. Dogs that received the treatment also showed higher potassium and magnesium levels, but the average levels stayed within the normal range.