Amiglyde-V 250mg Injection (48ml)

AMIGLYDE-V 250 mg Injection for Equine Uterine Infections

AMIGLYDE-V 250 mg Injection is a potent antimicrobial solution specifically formulated for the treatment of uterine infections in mares, including endometritis, metritis, and pyometra. This solution is particularly effective against bacterial strains such as Escherichia coli, Pseudomonas, and Klebsiella, even those resistant to other aminoglycosides like gentamicin and kanamycin.

By addressing these infections, AMIGLYDE-V significantly aids in restoring fertility and overall reproductive health in infected mares. For best results, it is recommended to confirm bacterial susceptibility with an amikacin susceptibility disc test before initiating treatment.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

NOTE: For generic medications, picture displayed may not depict actual product. Manufacturer may vary.

What Are the Benefits of AMIGLYDE-V for Equine Uterine Health?

• Broad-Spectrum Antibacterial: Effectively combats key pathogens (E. coli, Pseudomonas, Klebsiella) known to cause uterine infections in mares.
• Enhanced Fertility: Treating infections with AMIGLYDE-V has been clinically shown to improve fertility in mares with uterine infections.
• Potent Against Resistant Bacteria: Highly effective against bacterial strains resistant to other aminoglycosides, enhancing its efficacy.
• Safe and Well-Tolerated: AMIGLYDE-V has a favorable safety profile with no adverse side effects reported in mares.

How Should AMIGLYDE-V Be Administered?

• Dosage:
  • Administer 2 grams (8 mL) of Amiglyde-V, mixed with 200 mL of 0.9% Sodium Chloride Injection, USP.
  • Infuse aseptically into the uterus daily for three consecutive days.
  • Always consult your veterinarian for exact dosage instructions depending on your horse's condition.
• Preparation:
  • Ensure all equipment is sterile before preparation.
  • Mix the specified dose with the diluent under aseptic conditions.
• Administration:
  • Infuse the prepared solution into the uterus using appropriate intrauterine techniques.

Ingredients of AMIGLYDE-V 250 mg Injection

• Active Ingredient: Amikacin sulfate, 250 mg/mL

   

• Inactive Ingredients:

  • • Sodium Citrate, USP (2.5%), adjusted to pH 4.5 with sulfuric acid.
    • Sodium Bisulfite (0.66%).
    • Benzethonium Chloride, USP (0.01%) as a preservative.

   

Are There Any Side Effects with AMIGLYDE-V?

No adverse reactions or side effects have been reported with the use of Amiglyde-V in horses. However, always monitor your mare for any unusual signs following administration and consult your veterinarian if concerns arise. 

What Precautions Should Be Taken When Using Amiglyde-V 250mg Injection?

• Hypersensitivity: Do not use in horses with a known hypersensitivity to amikacin.
• Concurrent Aminoglycoside Use: Avoid concurrent use of other aminoglycosides due to potential additive effects.
• Breeding Considerations: In vitro studies have shown that the preservative in the 48 mL vials (250 mg/mL) can impair sperm viability; therefore, use caution when treating breeding mares.
• Human Consumption Warning: Do not use in horses intended for human consumption.

Storage Guidelines: How Should AMIGLYDE-V Be Stored?

• Temperature: Store at or below 25°C (77°F).
• Environment: Keep in a dry, cool place, away from direct sunlight.
• Caution: Ensure the product is kept out of reach of children and other animals to prevent accidental ingestion or misuse.

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FAQs - Amiglyde-V 250mg Injection for Mares

What is AMIGLYDE-V used for?

AMIGLYDE-V is used to treat uterine infections in mares, targeting pathogens like E. coli, Pseudomonas, and Klebsiella. It is particularly beneficial for improving fertility and overall reproductive health in mares with bacterial infections, especially those resistant to other aminoglycosides.

How does AMIGLYDE-V improve fertility in mares?

By effectively clearing uterine infections caused by common bacteria, AMIGLYDE-V helps restore the natural reproductive balance in mares, which can significantly increase their fertility and chances of successful breeding.

Is AMIGLYDE-V suitable for use in pregnant mares?

AMIGLYDE-V is generally safe, but its use in pregnant mares should always be guided by a veterinarian. Potential risks should be evaluated carefully, as the medication's impact on the developing fetus needs to be assessed based on individual cases.

Can AMIGLYDE-V treat infections in other animals besides mares?

AMIGLYDE-V is specifically formulated and FDA-approved for treating uterine infections in mares. While amikacin is used for infections in various animals, consult a veterinarian to determine if this specific formulation is appropriate for other animals.

How quickly does AMIGLYDE-V take effect in treating infections?

AMIGLYDE-V can start working within a few days of administration, but the full treatment duration depends on the severity of the infection and the individual mare’s response. Improvement in reproductive health may take weeks or longer as the infection clears.

Are there any known drug interactions with AMIGLYDE-V?

AMIGLYDE-V may interact with other antibiotics or medications. Always inform your veterinarian about any other treatments or medications the mare is receiving to prevent potential interactions and ensure optimal results.

How does AMIGLYDE-V compare to other aminoglycosides like gentamicin?

Unlike gentamicin, AMIGLYDE-V (amikacin) is often effective against bacteria that have developed resistance to other aminoglycosides. Its broad-spectrum activity makes it a preferred choice for treating stubborn infections in equine reproductive health.

How should I prepare my mare before administering AMIGLYDE-V?

Before administering AMIGLYDE-V, it is essential to have the mare evaluated by a veterinarian to confirm a bacterial infection. It’s also advisable to perform a bacterial culture to determine susceptibility, ensuring that AMIGLYDE-V is the right choice for effective treatment.

Can AMIGLYDE-V cause antibiotic resistance in mares?

As with any antibiotic, improper or prolonged use of AMIGLYDE-V may contribute to antibiotic resistance. To minimize this risk, it should be administered precisely as prescribed by a veterinarian and only when necessary for bacterial infections.

What follow-up care is recommended after using AMIGLYDE-V?

Post-treatment, a follow-up exam may be recommended to confirm that the infection has cleared and assess fertility. This ensures the mare’s reproductive health has fully improved and helps plan any future breeding efforts.

Additional Resources

For more information on Amiglyde-V and its use in veterinary medicine, consider the following reputable sources:

• Amiglyde-V Intrauterine Solution for Animal Use - Drugs.com
• Amiglyde-V - Zoetis Inc.: Veterinary Package Insert - VetLabel.com

These resources offer valuable insights into the proper use and considerations when administering Amiglyde-V to your horses.