Synchsure (Cloprostenol Sodium) Injection (100ml - 50 doses)

Synchsure for Cattle

Managing reproductive health in livestock, particularly in cattle and mares, is essential for achieving optimal breeding outcomes and overall herd productivity. 

Synchsure Cloprostenol Sodium Injection 100ml (50 Doses) is specifically formulated to help synchronize estrus in these animals, facilitating controlled breeding and improving fertility rates. 

This product is precious for addressing common reproductive challenges, such as silent heats, irregular estrus cycles, and the need for precise timing in artificial insemination programs.

Synchsure stands out in the market due to its proven effectiveness, ease of use, and cost-efficiency, providing 50 doses per vial. 

This ensures that large herds can be treated economically while minimizing the risks associated with dosage errors. Additionally, its fast-acting formula ensures timely results, allowing for better management of breeding schedules.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note that the product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

How It Works

Synchsure Cloprostenol Sodium Injection is a synthetic prostaglandin F2α analog, which mimics the naturally occurring prostaglandins in the animal's body. Prostaglandins play a crucial role in regulating the reproductive cycle, particularly in the luteolysis process, which is the breakdown of the corpus luteum in the ovary.

Here’s how Synchsure works:

1. Induces Luteolysis: After administration, Synchsure stimulates the regression of the corpus luteum, a structure in the ovary responsible for producing the hormone progesterone. This drop in progesterone levels is necessary for the new estrous cycle initiation.

1. Synchronizes Estrus: By controlling the timing of luteolysis, Synchsure allows for the synchronization of estrus (heat) in treated animals. This synchronization is critical for planning breeding schedules, especially in artificial insemination programs.
2. Triggers Ovulation: Following luteolysis, the animal’s body initiates the process leading to ovulation, allowing for precise timing of breeding or insemination to improve conception rates.

By effectively managing the reproductive cycle, Synchsure ensures that animals come into estrus at a predictable time which is vital for successful breeding and improved fertility outcomes.

Benefits of Synchsure

• Reliable Estrus Synchronization: Ensures consistent and predictable estrus cycles, essential for efficient breeding programs.
• Enhanced Fertility: Improves the success rates of breeding by addressing reproductive issues such as silent heats and irregular cycles.
• Cost-Efficient: Provides more doses per vial reducing overall treatment costs.
• Easy Administration: The clear instructions and user-friendly formulation make administration straightforward for veterinarians and breeders.
• Versatile Application: Suitable for use in both cattle and mares, making it a versatile solution for mixed-species farms.
• Fast-Acting: Works within 48-72 hours, ensuring timely estrus synchronization and reducing downtime between treatments.
• Precision Dosage: Minimizes the risk of overdose or underdose, ensuring optimal outcomes in estrus synchronization.

Ingredients

• Primary Ingredient: Cloprostenol Sodium (0.263 mg/mL)
• Secondary Ingredients: Sodium citrate, anhydrous citric acid, sodium chloride, and water for injection.

Synchsure Dosage and Administration

• Cattle: Administer 2mL intramuscularly. Depending on the breeding protocol, a second dose may be administered 11-14 days later.
• Mares: Administer 1mL intramuscularly, adjusting timing based on the specific breeding schedule.

Consistency

• Synchsure offers a consistent formulation ensuring uniform efficacy across all doses. This consistency is crucial for maintaining the reliability of estrus synchronization across multiple animals.

Side Effects of Cloprostenol Sodium Injection

• Mild Fever: Some animals may develop a low-grade fever shortly after administration, typically resolving within 24 hours.
• Injection Site Reactions: Swelling, redness, or slight pain at the injection site may occur but usually subsides on its own.
• Temporary Discomfort: Animals might exhibit temporary discomfort, restlessness, or sweating post-injection.
• Allergic Reactions: In rare cases, animals may experience an allergic reaction, manifesting as hives, swelling, or difficulty breathing. Immediate veterinary attention is required.
• Abortions: When administered to pregnant animals, Synchsure can induce abortion, which is a desired effect in some cases but a serious side effect if unintended.

Always monitor animals after administration and consult a veterinarian if any side effects occur.

Precautions

• Avoid using Synchsure in animals known to have hypersensitivity to cloprostenol. Monitor animals for any adverse reactions post-administration.
• Do not administer to pregnant animals unless the termination of pregnancy is desired. Using this product in non-target species can result in serious reproductive harm.

Warnings

• Abortifacient Potential: Synchsure may cause abortion in pregnant animals. Ensure that it is only administered to non-pregnant cattle and mares unless indicated otherwise by a veterinarian.
• Veterinary Use Only: This product is prescription-only and should be used under the guidance of a licensed veterinarian.

Storage

• Temperature: Store at 2°C - 8°C (36°F - 46°F).
• Protection: Keep the vial protected from light. Do not freeze the product.
• Usage Timeframe: Once the vial is opened, use the contents within 28 days to ensure efficacy.

Shipping & Returns 

• Shipping Policy: We offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.
• Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.
  

FAQs -  Synchsure (Cloprostenol Sodium) Injection

Q: How does Synchsure compare to other estrus synchronization products on the market?

A: Synchsure offers higher doses per vial and a reliable, fast-acting formula. It's cost-effective and provides consistent results, making it a preferred choice for large-scale operations.

Q: Can Synchsure be used in conjunction with other reproductive management products?

A: Yes, Synchsure can be used as part of a comprehensive reproductive management program, often in conjunction with other hormones or treatments. Always consult with a veterinarian to ensure compatibility.

Q: What should I do if I miss a scheduled dose of Synchsure?

A: If a dose is missed, consult with a veterinarian as soon as possible. The timing of the next dose may need adjustment to maintain estrus synchronization.

Q: How long does the effect of Synchsure last in the animal's system?

A: Synchsure initiates estrus typically within 48-72 hours, but the exact duration of its effect can vary. Consult with your veterinarian for specifics based on your breeding protocol.

Q: Can Synchsure be used during the off-breeding season?

A: Synchsure is typically used during the breeding season to synchronize estrus. Its use during the off-breeding season should be guided by a veterinarian.

Q: How should I dispose of any unused Synchsure?

A: Unused Synchsure should be disposed of following local regulations for medical waste. Do not flush or throw it away in regular trash.

Q: What should I do if I suspect an overdose of Synchsure?

A: If you suspect an overdose, contact a veterinarian immediately. Symptoms of overdose may include excessive sweating, restlessness, or signs of discomfort.

Q: Can Synchsure be used for estrus synchronization in other species?

A: Synchsure is specifically formulated for cattle and mares. Its use in other species should only be done under the direct guidance of a veterinarian.

Q: What are the first signs that Synchsure is working after administration?

A: The first signs include behavioral changes such as increased restlessness and a willingness to mate. These signs usually appear within 48-72 hours post-administration.

Clinical Research: 

https://academic.oup.com/jas/article/101/Supplement_1/57/7151391

https://repository.arizona.edu/bitstream/handle/10150/671221/az2065-2023.pdf?sequence=1&isAllowed=y