Apoquel (Oclacitinib) Tablets for Dogs, 3.6mg

Zoetis SKU: 10022315-1


Shipping calculated at checkout

Available Now!

1 Tablet
30 Tablets
60 Tablets
100 Tablets
250 Tablets

Add to Cart

Apoquel (oclacitinib) Tablets, 3.6mg, provide an effective solution for managing itching and inflammation in dogs caused by allergic dermatitis. This medication offers rapid relief within hours and is suitable for long-term use, ensuring your pet enjoys a comfortable, itch-free life. Trusted by veterinarians, Apoquel is renowned for its efficacy and safety in treating various types of dermatitis in dogs.

Apoquel is available in both oral and chewable tablet forms. Unlike other allergy medications, it targets the source of irritation, relieving itch and inflammation by addressing the underlying causes. It begins to alleviate symptoms within 4 hours and controls itching effectively within 24 hours. 

How Apoquel® Works?

The active component of Apoquel® is oclacitinib, which is classified as a Janus kinase (JAK1) inhibitor. The mechanism of action of Apoquel® is to inhibit the actions of Janus kinase, a crucial signal that causes inflammation and itching in dogs with allergies. 

This lessens the cellular source of itching and minimizes the impact of some inflammatory signals in the body. Consequently, dogs with allergies who receive Apoquel® experience reduced itching and scratching. Allergy-induced skin irritation is also reduced.

Benefits of Apoquel Tablets for Dogs

Apoquel delivers numerous benefits to both pets and their owners:

  • Rapid Relief: Apoquel starts alleviating itching within just 4 hours and controls it within 24 hours, offering quick comfort for dogs suffering from allergic reactions​.
  • Effective Long-term Management: Suitable for chronic conditions, Apoquel helps manage symptoms of allergic and atopic dermatitis for extended periods without the side effects commonly associated with steroids​.
  • Ease of Use: This medication can be administered with or without food, providing flexibility and ease for pet owners​.
  • Versatile Application: Apoquel is effective for both short-term flare-ups and long-term management of allergic symptoms, making it a versatile treatment option​​.
  • Clinically Proven: Backed by extensive clinical studies, Apoquel has been proven effective in reducing itching and inflammation in dogs, ensuring its reliability and safety​​.


Apoquel is indicated for the relief of itching and inflammation caused by allergic skin disease (atopy, atopic dermatitis) in dogs 12 months of age or older.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Apoquel Dosage and Administration

Proper dosing and administration are key to the effectiveness of Apoquel:

  • Initial Dosage: Administer 0.4-0.6 mg/kg twice daily for up to 14 days. This initial period helps bring symptoms under control quickly.

  • Maintenance Dosage: After the initial period, reduce to once daily for ongoing management. This maintenance dose helps keep allergic symptoms at bay over the long term​​.

Possible Side Effects of Apoquel® in Dogs

The most common side effects include:

  • Gastrointestinal upset (vomiting, diarrhea, loss of appetite) and
  • Low energy (lethargy)

Both of these are typically short-term and resolve on their own. However, there are some less common side effects, such as:

  • Elevated liver levels
  • Skin and ear infection
  • Seizures
  • Increased thirst
  • Demodicosis (skin infection caused by Demodex mites)
  • Cancer
  • Skin masses

Usage Restrictions

Apoquel is not recommended for dogs under 12 months of age or those with serious infections. It should also not be used in breeding, pregnant, or nursing dogs​.

Precautions for Dogs and Dog Owners:

  • Dogs receiving APOQUEL CHEWABLE should be monitored for the development of infections, including demodicosis, and neoplasia.

  • The APOQUEL CHEWABLE has not been evaluated in combination with glucocorticoids, cyclosporine, or other systemic immunosuppressive agents.

  • This product is not for human use. 

  • Keep this and all drugs out of reach of children. 

  • For use in dogs only. 

  • Wash hands immediately after handling the tablets. 


  • APOQUEL CHEWABLE modulates the immune system.

  • APOQUEL CHEWABLE is not for use in dogs with serious infections.

  • APOQUEL CHEWABLE may increase susceptibility to infection, including demodicosis, and exacerbation of neoplastic conditions.

  • New neoplastic conditions (benign and malignant) were observed in dogs treated with oclacitinib film-coated tablets (FCT) during clinical studies and have been reported in the post-approval period.

  • Consider the risks and benefits of treatment before initiating APOQUEL CHEWABLE in dogs with a history of recurrent serious infections or recurrent demodicosis or neoplasia.

  • Keep APOQUEL CHEWABLE in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.


Storage Conditions:

APOQUEL CHEWABLE should be stored at controlled room temperature between 20° to 25°C (68° to 77°F) with excursions between 15° to 40°C (59° to 104°F).

Shipping & Returns 

Shipping Policy: We offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Apoquel Tablets for Dogs FAQs

1. What is Apoquel used for?

The only Janus kinase (JAK) inhibitor currently licensed for use in dogs is Apoquel. It is used to treat atopic dermatitis and relieve itch brought on by allergic dermatitis.

2. How effective is Apoquel?

The most often given oral medication for allergic itch1, Apoquel, works well for

  • Flea allergy
  • Food allergy
  • Contact allergy
  • Atopic dermatitis

3. What is the most important thing I should know about Apoquel 3.6mg?

Apoquel Chewable is used to treat atopic dermatitis and allergic dermatitis, among other conditions that cause irritation and itching. However, it cannot be used in breeding, pregnant, or nursing dogs​.

4. What should I discuss with my veterinarian before giving Apoquel 3.6mg to my pet?

If your pet has ever experienced an allergic response to a drug, let your veterinarian know.

5. What are the potential side effects of Apoquel oclacitinib for Dogs?

Apoquel Chewable may make your furry friend more vulnerable to infections, such as demodicosis. 

Additionally, it might make neoplastic diseases worse. Several adverse effects that were recorded included lethargy, vomiting, diarrhea, anorexia, and new cutaneous or subcutaneous tumors. With maintained dosage, the majority of cases of diarrhea, vomiting, anorexia, and lethargy resolved on their own.

6. What happens if I miss giving a dose of Apoquel 3.6mg?

Give the missed dose with food as soon as you remember and resume a regular dosing schedule.

7. What happens if I overdose my pet on Apoquel 3.6mg?

Contact your veterinarian immediately.

8. What should I avoid while giving Apoquel to my pet?

  • Dogs with severe illnesses or those under 12 months old shouldn't be given Apoquel Chewable. 

  • It is not recommended to use Apoquel Chewable on dogs who are pregnant or nursing canines. 

  • Apoquel Chewable has not been tested in conjunction with cyclosporine, glucocorticoids, or any other systemic immunosuppressive medication. 

  • It is important to keep an eye out for infections in dogs on Apoquel Chewable, such as demodicosis and neoplasia.

9. What other drugs will affect the Apoquel tablet?

It depends from dog to dog according to their age, weight, and medical history. Talk to your veterinarian before giving any prescription or over-the-counter medications.

10. Is there a generic for oclacitinib for dogs?

As of now, there is no generic equivalent for oclacitinib (Apoquel) for dogs. Apoquel is the brand name and is manufactured by Zoetis.