Tri-Heart Plus for Dogs 51-100 lbs
For use in animals only. Tri-Heart Plus is an easy-to-feed chewable tablet prescribed to help keep your dog free of heartworm and other dangerous parasites. When given monthly, this simple and palatable tablet helps to protect your pet by killing the larvae before they reach your dog's heart. Best of all, the tasty tablets can be fed just like a treat! Your pet won't even know you're working to protect their heart.
Chewable tablets containing ivermectin and pyrantel. For use in dogs to prevent canine heartworm disease by eliminating the tissue stage of heartworm larvae (Dirofilaria immitis) for a month after infection and for the treatment and control of ascarids (Toxocara canis, Toxascaris leonina) and hookworms (Ancylostoma caninum, Uncinaria stenocephala, Ancylostoma braziliense).
- Tasty flavored chewable tablets
- Easy to administer
- Small, easy-to-chew tablet for smaller or finicky dogs
- Given once a month
Dosage and Administration:
Tri-Heart Plus should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:
| Dog Weight | Chewable Tablets per Month | Ivermectin Content | Pyrantel Content | Color Coding on Blister Card and Carton |
|---|---|---|---|---|
| Up to 25 lbs | 1 | 68 mcg | 57 mg | One |
| 26 to 50 lbs | 1 | 136 mcg | 114 mg | Green |
| 51 to 100 lbs | 1 | 272 mcg | 227 mg | Brown |
Tri-Heart Plus is recommended for dogs 6 weeks of age and older. For dogs over 100 lbs, use the appropriate combination of these tablets.
ADMINISTRATION:
Remove only one chewable tablet at a time from the blister card. Because most dogs find Tri-Heart Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dry food or placed in the back of the dog’s mouth for forced swallowing.
Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.
Tri-Heart Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.
When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of Tri-Heart Plus must be given within a month (30 days) of the last dose of the former medication.
If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with Tri-Heart Plus and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
Monthly treatment with Tri-Heart Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
PRECAUTIONS:
All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart Plus.
While some microfilariae may be killed by the ivermectin in Tri-Heart® Plus at the recommended dose level, Tri-Heart Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.
Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.
Store at controlled room temperature of 59-86° F (15-30° C). Protect product from light.
FAQ
- Our dog's Tri-Heart Plus flavored chewable tablets expired last month. Is it still okay to give her Tri-Heart Plus tablets after their expiration date?
- Medications, including Tri-Heart Plus, should never be administered after the expiration date. Studies have shown that Tri-Heart Plus will maintain its desired effectiveness when administered prior to the expiration date, when stored as recommended on the label.
- My dog weighs less than 10 lbs. Should I give him the whole tablet even though it says for dogs up to 25 lbs?
- Yes. The entire tablet should be administered as a single dose once each month. The smallest-sized Tri-Heart Plus tablet, in the blue-colored packaging, is labeled for dogs weighing 25 lbs or less. These tablets are scored to make it easier to break the tablet apart and have the small dog take the complete tablet but in smaller pieces at a time. Regardless of whether the tablet is broken apart or given whole, the entire tablet should be given as a single dose.
- Is it okay to give my pregnant dog Tri-Heart Plus tablets? What about after she has given birth and is breastfeeding the puppies?
- Ivermectin/pyrantel, the active ingredients in Tri-Heart Plus, have a wide margin of safety at the recommended dose level in dogs, including pregnant females, breeding males and females, and puppies 6 weeks old or more according to the package insert.
- I accidentally gave my dog his Tri-Heart Plus tablet after my husband had already given one to him. Will he be okay?
- Contact your veterinarian immediately if accidental overdose occurs. To reduce the risk of accidental overdose in situations where more than one person may administer Tri-Heart Plus, we suggest ticking off the date on a specially marked calendar or making some other note to indicate that the dose has been given. Make a habit of checking with the other pet caregivers in your household before giving any medications to your pet.
- My dog is taking some other medications for another condition. Is it still safe to give her Tri-Heart Plus tablets?
- In clinical trials, many commonly used flea collars, dips, shampoos, antihelmintics (deworming medications), antibiotics, vaccines, and steroid preparations have been administered with ivermectin/pyrantel in a heartworm disease preventive program. For questions on specific medications, please consult with your veterinarian.
- I forgot to give my dog his Tri-Heart Plus medication last month. Is he still protected? What should I do?
- If the interval between doses exceeds 30 days, the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable tablet must be given once a month, on or about the same day of the month (Sign up for our email reminder service). If treatment is delayed, whether by a few days or many, please contact your veterinarian, as immediate treatment with Tri-Heart Plus chewable tablets and resumption of the recommended dosing regimen minimizes the opportunity for the development of adult heartworms.
- Where can I buy Tri-Heart Plus tablets?
- Tri-Heart Plus flavored chewable tablets can be obtained by prescription only and are available from your veterinarian.
- Is Tri-Heart Plus safe for my dog?
- Tri-Heart Plus flavored chewable tablets are an FDA-licensed product, indicating that they are safe and effective when used as recommended on the label. All dogs should be tested for existing heartworm infection before starting treatment with Tri-Heart Plus.
- How long will the Tri-Heart Plus tablets last once removed from the blister pack?
- The blister package is designed to protect the tablets from exposure to air and light. Therefore a tablet should be administered at the time it is removed from the blister foil. Also if the blister or foil is not intact (for example the foil is peeled back or there's a hole in it), the tablet should not be used.
- Can Tri-Heart Plus be used as a heartworm preventive in cats?
- No. Tri-Heart Plus is not approved for use in cats.
- Do Tri-Heart Plus tablets contain wheat or rice gluten?
- No.
- Can Tri-Heart Plus tablets be given to a dog that has heartworms or that is heartworm positive?
- No. Tri-Heart Plus is labeled for use in dogs to prevent heartworm disease and not for the treatment of heartworm infections. The package insert contains a precautionary statement that 'Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with Tri-Heart Plus flavored chewable tablets.
- All dogs should be tested for heartworm infection before starting a preventive program. In a small percentage of ivermectin/pyrantel treated dogs, digestive and neurological side effects may occur.
Recommended for the Tri-Heart Plus for Dogs 51-100 lbs
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