Heartgard Plus Chew for Dogs, up to 25 lbs

Boehringer Ingelheim SKU: 145448-BI-1


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1 Chew (1 Month Supply)
3 Chew (3 Month Supply)
6 Chews (6 Months Supply)
12 Chews (12 Months Supply)

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Heartgard Plus for Dogs up to 25 lbs

Heartgard Plus Chew for Dogs, up to 25 lbs. is a heartworm prevention for dogs that kills heartworms and also helps treat and control roundworms and hookworms. It comes in a delicious once-a-month, real-beef chew that dogs love and is safe for puppies 6 weeks and older.

Features & Benefits

  • Once-a-month real-beef chew that dogs prefer
  • #1 vet-recommended heartworm prevention for dogs
  • #1 dog heartworm prevention
  • The heartworm preventive in HEARTGARD Plus chews has been trusted over 2 billion times
  • Safe for puppies 6 weeks of age or older with no minimum weight requirement
  • The dose of ivermectin in HEARTGARD Plus chews is essentially excreted in 72 hours
  • Treats and controls 3 species of hookworms and 2 species of roundworms
  • HEARTGARD Plus chews offer the HEARTGARD Plus Satisfaction Guarantee

Heartworm disease is an invisible threat. Mosquitoes pick up heartworm larvae, called microfilariae, when they bite an infected animal. When the mosquitoes fly to their next meal, the microfilariae come along for the ride like microscopic passengers flying to a new destination.

heartgard plus heartowrm life cycle

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Dosage and Administration:

HEARTGARD Plus (ivermectin/pyrantel) should be administered orally at monthly intervals at the recommended minimum dose level of 6 mcg of ivermectin per kilogram (2.72 mcg/lb) and 5 mg of pyrantel (as pamoate salt) per kg (2.27 mg/lb) of body weight. The recommended dosing schedule for prevention of canine heartworm disease and for the treatment and control of ascarids and hookworms is as follows:

Dog Weight Chewable Per Month Ivermectin Content Pyrantel Content Color Coding on Foil Backing and Carton
Up to 25 lb 1 68 mcg 57 mg Blue
26 to 50 lb 1 136 mcg 114 mg Gree
51 to 100 lb 1 272 mg 227 mg Brown

HEARTGARD Plus is recommended for dogs 6 weeks of age and older.

For dogs over 100 lb use the appropriate combination of these chewables.


Remove only one chewable at a time from the foil-backed blister card. Return the card with the remaining chewables to its box to protect the product from light. Because most dogs find HEARTGARD Plus palatable, the product can be offered to the dog by hand. Alternatively, it may be added intact to a small amount of dog food. The chewable should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes after administration to ensure that part of the dose is not lost or rejected. If it is suspected that any of the dose has been lost, redosing is recommended.

HEARTGARD Plus should be given at monthly intervals during the period of the year when mosquitoes (vectors), potentially carrying infective heartworm larvae, are active. The initial dose must be given within a month (30 days) after the dog’s first exposure to mosquitoes. The final dose must be given within a month (30 days) after the dog’s last exposure to mosquitoes.

When replacing another heartworm preventive product in a heartworm disease preventive program, the first dose of HEARTGARD Plus must be given within a month (30 days) of the last dose of the former medication.

If the interval between doses exceeds a month (30 days), the efficacy of ivermectin can be reduced. Therefore, for optimal performance, the chewable must be given once a month on or about the same day of the month. If treatment is delayed, whether by a few days or many, immediate treatment with HEARTGARD Plus and resumption of the recommended dosing regimen will minimize the opportunity for the development of adult heartworms.

Monthly treatment with HEARTGARD Plus also provides effective treatment and control of ascarids (T. canis, T. leonina) and hookworms (A. caninum, U. stenocephala, A. braziliense). Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


All dogs should be tested for existing heartworm infection before starting treatment with HEARTGARD Plus which is not effective against adult D. immitis. Infected dogs must be treated to remove adult heartworms and microfilariae before initiating a program with HEARTGARD Plus.

While some microfilariae may be killed by the ivermectin in HEARTGARD Plus at the recommended dose level, HEARTGARD Plus is not effective for microfilariae clearance. A mild hypersensitivity-type reaction, presumably due to dead or dying microfilariae and particularly involving a transient diarrhea, has been observed in clinical trials with ivermectin alone after treatment of some dogs that have circulating microfilariae.

Keep this and all drugs out of the reach of children. In case of ingestion by humans, clients should be advised to contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans.

Store between 68°F - 77°F (20°C - 25°C). Excursions between 59°F - 86°F (15°C - 30°C) are permitted. Protect product from light.


What is the most important thing I should know about Heartgard Plus Chewables?
The active ingredients in Heartgard Plus Chewables are ivermectin and pyrantel pamoate. Use with caution, as Collies and other herding dog breeds have been known to have adverse reactions to ivermectin administered at elevated dose levels. Heartworm testing should be performed prior to the start of prevention therapy. If your pet is off Heartgard Plus Chewables for 6 months or less, start the medication and test after 6 months since microfilaria, that take 6 months to mature, will result in a positive test result. In addition, Heartgard Plus Chewables have shown a wide margin of safety at the recommended dose level in dogs including pregnant or breeding dogs, stud dogs and puppies aged 6 or more weeks.

What should I discuss with my veterinarian before giving Heartgard Plus Chewables to my pet?
Tell your veterinarian if your pet has ever had an allergic reaction to the medication, any of its individual ingredients, or to beef.

How should Heartgard Plus Chewables be given?
Give Heartgard Plus Chewables exactly as directed by your veterinarian. If you do not understand the directions, ask your pharmacist or veterinarian to explain them to you. Heartgard Plus Chewables must be chewed. They should not be swallowed whole.

What are the potential side effects of Heartgard Plus Chewables?
Side effects of Heartgard Plus Chewables are rare at the recommended heartworm prevention dose. Higher doses in dogs may cause tremors, dilated pupils, loss of body weight and/or death.

What happens if I miss giving a dose of Heartgard Plus Chewables?
Give the missed dose as soon as you remember. Do not give a double dose of the medication.

What happens if I overdose my pet on Heartgard Plus Chewables?
Seek emergency veterinary medical treatment.

What should I avoid while giving Heartgard Plus Chewables to my pet?
Because humans can contract hookworm from animals, it is important to maintain good personal hygiene. It is also important to eliminate fleas on your pet and in the household and to not feed your pet rodents or uncooked meat or fish. To prevent reinfection, daily cleanup of stools is recommended.

What other drugs will affect Heartgard Plus Chewables?
Do not give Heartgard Plus Chewables to your pet if he or she is already taking another heartworm medication.