Simparica Trio for Dogs 44.1-88 lbs

Zoetis SKU: 10022670


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12 Chewable Tablets

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Simparica Trio for Dogs 44.1-88 lbs: Complete Protection

Simparica Trio is the first and only product to combine moxidectin, sarolaner, and pyrantel in each treatment. These three work together to effectively prevent heartworm disease and get rid of fleas before egg laying. Simparica Trio for dogs targets 5 types of ticks, prevents flea infestations, and controls roundworms and hookworms. Simparica Trio chewable tablets for dogs come in a delicious liver flavor that your pup will love!  

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Dosage and Administration:

SIMPARICA TRIO is given orally once a month, at the recommended minimum dose of 0.54 mg/lb (1.2 mg/kg) sarolaner, 0.011 mg/lb (24 µg/kg) moxidectin, and 2.27 mg/lb (5 mg/kg) pyrantel (as pamoate salt).

Dosage Schedule

Body Weight (lbs) Sarolaner per Tablet (mg) Moxidextin per tablet (mg) Pyrantel per Tablet (mg) Number of Tablets Administered
2.8 to 5.5 lbs 3 0.06 12.5 One
5.6 to 11.0 6 0.12 25 One
11.1 to 22.0 12 0.24 50 One
22.1 to 44.0 24 0.48 100 One
44.1 to 88.0 48 0.96 200 One
88.1 to 132.0 72 1.44 300 One
›132.0 Administer the appropriate combination of tablets.

SIMPARICA TRIO can be offered to the dog with or without food.

Care should be taken to ensure that the dog consumes the complete dose and that part of the dose is not lost or refused. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing.

Heartworm Prevention:

SIMPARICA TRIO should be administered at monthly intervals year.round or at least within one month of the animal’s first seasonal exposure to mosquitoes and continuing until at least 1 month after the dog’s last seasonal exposure. If a dose is missed, give SIMPARICA TRIO immediately and resume monthly dosing. When replacing a monthly heartworm preventive product, SIMPARICA TRIO should be given within one month of the last dose of the former medication.

Flea Treatment and Prevention:

Treatment with SIMPARICA TRIO may begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before fleas become active.

To minimize the likelihood of flea re-infestation, it is important to treat all dogs and cats within a household with a flea control product.

Tick Treatment and Control:

Treatment with SIMPARICA TRIO can begin at any time of the year. SIMPARICA TRIO should be administered year-round at monthly intervals or started at least one month before ticks become active.

Intestinal Nematode Treatment and Control:

For the treatment of roundworm (immature adult and adult Toxocara canis and adult Toxascaris leonina) and hookworm (L4, immature adult, and adult Ancylostoma caninum and adult Uncinaria stenocephala) infections, SIMPARICA TRIO should be administered once as a single dose. Monthly use of SIMPARICA TRIO will control any subsequent infections.


There are no known contraindications for the use of SIMPARICA TRIO.


Not for use in humans. Keep this and all drugs out of reach of children.

Keep SIMPARICA TRIO in a secure location out of reach of dogs, cats and other animals to prevent accidental ingestion or overdose.


Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. Neurological adverse reactions, including tremors, ataxia, and seizures, have been associated with this class of medication. Dogs treated with drugs from the isoxazoline class may experience neurological symptoms, regardless of their medical history. Use with caution in dogs with a history of neurologic disorders.

Prior to administration of SIMPARICA TRIO, dogs should be tested for existing heartworm infections. Infected dogs should be treated with an adulticide to remove adult heartworms. SIMPARICA TRIO is not effective against adult D. immitis.

The safe use of SIMPARICA TRIO has not been evaluated in breeding, pregnant, or lactating dogs.


How is Simparica Trio different from other preventatives?
Simparica Trio is the first monthly chewable to protect dogs against heartworm disease, 5 types of ticks, fleas, roundworms and hookworms, all in only one monthly chewable.

Is Simparica Trio safe?
Simparica Trio is safe for dogs as young as 8 weeks old, and weighing as little as 2.8 lbs.

How often do you give Simparica Trio?
Simparica trio chewables are given once a month unless otherwise directed by your vet. 

How do I switch from another heartworm medication or tick and flea medication?
Talk to your vet today to see if Simparica Trio is right for your dog. Hardy Paw offers a bunch of heartworm & flea and tick medications if Simparica Trio isn't the one for your dog. 
Flea & Tick Medication (
Heartworm Preventives (

Do I need a prescription for Simparica Trio?
Yes, your vet can prescribe the correct dose for your dog. 

What if I’m late giving a Simparica Trio dose?
Give a new dose as soon as you realize you missed one. Also, give a new dose if your dog vomits or spits out the chew. Then, continue on the prescribed monthly dosing schedule. 

How fast does Simparica Trio work to kill ticks and fleas?
Simparica Trio starts killing ticks within 8 hours and fleas within 4 hours. These chews reach their maximum effectiveness within 24 hours of administration. 

When can I start Simparica Trio for a puppy?
You can begin using Simparica Trio with puppies as young as 8 weeks old weighing at least 2.8 lbs.

Can Simparica Trio help to prevent Lyme infections?
Simparica Trio is FDA-approved to prevent infections that may cause Lyme disease by killing deer ticks.