Sileo (dexmedetomidine oromucosal) Oromucosal Gel for Dogs

Calm Relief for Dogs With Noise Aversion

Product Description

Sileo is a prescription oromucosal gel formulated to help dogs manage fear and anxiety caused by loud noises such as fireworks. It contains dexmedetomidine, an alpha 2 adrenoceptor agonist that calms dogs without heavy sedation. Applied between the cheek and gum, it allows dogs to remain awake, responsive, and comfortable during stressful noise events.

Benefits

• Targeted calming: Helps reduce fear and anxiety behaviors linked to loud noise exposure in dogs.
• Non-sedating action: Keeps dogs calm yet alert, allowing normal interaction during noise events.
• Fast absorption: Oromucosal delivery allows effective absorption without relying on digestion.
• Event-based dosing: Designed for use before or during predictable noise-triggering situations.
• FDA-approved use: Approved specifically for canine noise aversion under veterinary supervision.

Variants

• 1 x 3 mL syringe
• 3 x 3 mL syringes
• 5 x 3 mL syringes
• 10 x 3 mL syringes
• 20 x 3 mL syringes

Ingredients

Active Ingredients

Dexmedetomidine as dexmedetomidine hydrochloride.

Inactive Ingredients

Inactive ingredients are not publicly specified by the manufacturer.

How to Use

Recommended-Dosage Chart

Each “dot” equals 0.25 mL as measured using the dosing ring on the SILEO syringe.
Source: SILEO FDA Approved Label, Zoetis Inc.

Dosage & Administration Instructions

• Oromucosal Placement: Administer between cheek and gum to ensure absorption through oral mucosa and avoid swallowing.
• Do Not Swallow: If swallowed, effectiveness may decrease and re-dosing must wait at least two hours.
• Timing Before Noise: Give first dose 30 to 60 minutes before expected noise or at first anxiety signs.
• Two Hour Interval: Maintain minimum two hours between doses and do not exceed five doses per event.
• Divide Large Doses: Split doses exceeding six dots evenly between both sides of the mouth.
• Use Dosing Syringe: Always administer using supplied syringe to prevent incorrect dosing or overdose.
• Adult Administration: An adult should administer while wearing impermeable disposable gloves for safety.
• Prescription Only: Use only under direction of a licensed veterinarian as required by federal law.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Health conditions: Not labeled for dogs with severe cardiovascular, respiratory, liver, or kidney disease.
• Temperature sensitivity: Sensitive dogs may experience reduced body temperature and should be monitored closely.
• Drug interactions: Concurrent use with other central nervous system depressants may increase effects.
• Age limitations: Safety has not been evaluated in dogs younger than sixteen weeks of age.
• Reproductive safety: Use in breeding, pregnant, or lactating dogs has not been evaluated.

Possible Side Effects

• Mild sedation: Some dogs may appear drowsy or mildly sedated following labeled use.
• Gastrointestinal signs: Vomiting or gastrointestinal upset has been reported in a small number of cases.
• Pale gums: Temporary pale mucous membranes may be observed and typically resolve without treatment.
• Urinary changes: Urinary incontinence or inappropriate urination has been reported infrequently.

Storage Information

• Temperature range: Store at controlled room temperature between 20°C and 25°C.
• Original packaging: Syringes should be kept in the original carton to protect product stability.
• Opened syringe: Contents should be used within four weeks after initial opening.

Shipping & Return

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is Sileo used for in dogs?

Ans: Sileo is an FDA-approved prescription medication indicated for treating noise aversion in dogs. It is labeled to help reduce fear and anxiety behaviors triggered by loud noises such as fireworks, while allowing dogs to remain calm, responsive, and functional during the event.

Q2: How does Sileo work to calm dogs?

Ans: Sileo contains dexmedetomidine, an alpha 2 adrenoceptor agonist that reduces noradrenaline release in the brain. When applied to the oral mucosa, it is absorbed without first-pass metabolism, producing a calming effect without causing deep sedation in dogs during noise-related stress events.

Q3: How often can Sileo be given during a noise event?

Ans: According to manufacturer labeling, Sileo is approved for event-based dosing during noise episodes. Treatment may be repeated if anxiety signs return, with at least two hours between doses, and no more than five doses during a single noise event.

Q4: Does Sileo cause heavy sedation in dogs?

Ans: Sileo is formulated at a low dose to keep dogs calm without full sedation. Clinical studies reported most dogs remained alert and functional, though some experienced mild drowsiness or temporary sedation, which typically resolved within a few hours after dosing.

Q5: How should Sileo be stored after opening?

Ans: Manufacturer guidance states that Sileo syringes should be stored at controlled room temperature in their original packaging. Once opened, a syringe may be reused if sufficient gel remains, but contents should be used within four weeks of opening, as labeled.