Trifexis for Dogs 5-10 lbs

Elanco SKU: CA4332Y07AM-1


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1 Chewable Tablet (1 Month Supply)
6 Chewable Tablets (6 Months Supply)
12 Chewable Tablets (12 Months Supply)

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Trifexis for Dogs 5-10 lbs

Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm, and whipworm infections in dogs. With flea medicine, heartworm prevention, and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

  • Begins eliminating fleas in just half an hour
  • Persists for an entire month
  • Prevents fleas from laying eggs by killing them beforehand.
  • Arrives in a handy beef-flavored chewable tablet.
  • Spinosad, found in Comfortis, is eco-friendly.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.


TRIFEXIS is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes.

Dosage Schedule:

Body Weight Spinosad Per Tablet (mg) Milbemycin oxime Per Tablet (mg) Tablets Administered
5 to 10 lbs 140 2.3 One
10.1 to 20 lbs 270 4.5 One
20.1 to 40 lbs 560 9.3 One
40.1 to 60 lbs 810 13.5 One
60.1 to 120 lbs 1620 27 One
Over 120 lbs Administer the appropriate combination of tablets

Administer TRIFEXIS with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of TRIFEXIS with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.

Heartworm Prevention:

TRIFEXIS should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure and continuing until at least 3 months after the dog’s last seasonal exposure to mosquitoes. TRIFEXIS may be administered year-round without interruption. When replacing another heartworm preventative product, the first dose of TRIFEXIS should be given within a month of the last dose of the former medication.

Flea Treatment and Prevention:

Treatment with TRIFEXIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with TRIFEXIS should continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.

Intestinal Nematode Treatment and Control:

TRIFEXIS also provides treatment and control of roundworms (T. canis, T. leonina), hookworms (A. caninum), and whipworms (T. vulpis). Dogs may be exposed to and can become infected with roundworms, whipworms, and hookworms throughout the year, regardless of season or climate. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.


There are no known contraindications to the use of TRIFEXIS.


Not for human use. Keep this and all drugs out of the reach of children.

Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of TRIFEXIS.


Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention.

Storage Information:

Store at 20-25°C (68-77°F), excursions permitted between 15-30°C (59-86°F).


Do I have to give Trifexis with food?
Administer Trifexis with food for maximum effectiveness. Trifexis is a chewable beef-flavored tablet that can be given as a treat.

Does seeing fleas on my dog mean the treatment is not working?
Trifexis kills fleas on dogs before they can lay eggs when used monthly and according to the label directions. Remember that all animals in the household should be treated with an approved flea product to help control the flea population. Your dog can continue to be exposed to fleas that live in the environment. When fleas jump onto and bite your dog, they will be killed by Trifexis. If, within a month after your dog receives Trifexis, you see fleas on your dog, they are most likely new fleas. These new fleas will be killed before they can produce eggs that contaminate the environment. Continued monthly use of Trifexis can protect against any new infestations.

What if I see worms in my dog’s stool during the month after administration of Trifexis?
Trifexis is indicated to treat and control intestinal parasite infections of adult hookworms, roundworms, and whipworms in dogs. In occasional cases, you might see intestinal worms being expelled in your dog’s stool — this means Trifexis is working. If you have questions, consult your veterinarian for measures you can take to prevent reinfection of intestinal parasites.

What are the active ingredients in Trifexis?
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.

If spinosad kills fleas, is it safe for my dog?
Trifexis has been demonstrated to be safe in healthy dogs when used according to label directions. Spinosad, one of its active ingredients, is produced by a bacterium first isolated from natural sources (a soil sample collected in the Caribbean).

  1. Spinosad selectively targets the nervous system of the flea (and other insects) due to differences in the targeted receptors compared to mammalian nervous systems.
  2. However, as with all medications, sensitivities in individual animals can occur, sometimes resulting in side effects. See the Trifexis label for complete safety information.

Can Trifexis be given to cats?
No, Trifexis is not approved for use in cats. Trifexis was developed exclusively for administration to dogs.