The Ultimate Protection Against Parasites
Trifexis is a veterinary-approved oral medication that provides broad-spectrum parasite protection for dogs. This monthly chewable tablet is a 3-in-1 parasite preventive, effectively targeting:
- Fleas – Kills adult fleas before they lay eggs, breaking the infestation cycle.
- Heartworms – Prevents deadly heartworm disease by eliminating heartworm larvae.
- Intestinal Parasites – Treats and controls roundworms, hookworms, and whipworms.
Formulated with spinosad and milbemycin oxime, Trifexis ensures comprehensive internal and external parasite protection with just a single dose per month. Unlike topical treatments, this oral flea and heartworm prevention for dogs eliminates concerns about messy application and accidental contact with children or other pets.
About Trifexis
Trifexis is a vet-recommended, FDA-approved oral medication that provides all-in-one protection against fleas, heartworms, and intestinal parasites. Made by Elanco Animal Health, it combines spinosad and milbemycin oxime for fast-acting, long-lasting parasite control. Unlike messy topicals, this easy-to-administer chewable ensures hassle-free, waterproof protection—keeping your dog healthy year-round.
What Are the Benefits of Trifexis for Dogs?
Trifexis offers multi-layered protection with several key advantages:
- Triple Defense Protection – Fights fleas, prevents heartworms, and controls intestinal parasites in one simple chewable tablet.
- Fast-Acting Flea Treatment – Begins killing fleas within 30 minutes, eliminating 100% of adult fleas within 4 hours.
- Heartworm Disease Prevention – Protects against life-threatening heartworm infection when given consistently every month.
- Convenient Oral Administration – No messy topical application; a beef-flavored chew makes it easy to administer.
- Waterproof Protection – Since it's an oral medication, it works regardless of swimming or bathing.
- Veterinarian-Recommended – Clinically proven and trusted by veterinarians for parasite prevention in dogs.
- No Prescription Topical Mess – Unlike spot-on treatments, there’s no risk of residue rubbing off on furniture or people.
What Are the Ingredients in Trifexis Medicines?
Trifexis contains two active ingredients that provide superior parasite protection:
- Spinosad – A fast-acting insecticide that kills fleas by overactivating their nervous system.
- Milbemycin Oxime – A broad-spectrum antiparasitic that prevents heartworms and treats roundworms, hookworms, and whipworms.
Featured Products – Trifexis Chewables for Dogs
Keep your dog protected with the right Trifexis chewable tablet based on their weight. Choose from the following options:
Find the right Trifexis dose for your dog and ensure complete parasite protection with just one chewable per month!
How to Administer Trifexis Medicines for Dogs
Always consult your veterinarian for exact dosage instructions based on your dog’s weight and health condition.
- Administer once a month with food to ensure optimal absorption.
- Available in five weight-based dosages, ensuring precise dosing for dogs weighing 5 lbs to 120 lbs.
- If a dose is missed, administer as soon as possible and resume the regular schedule.
Trifexis Dosage Chart
- 5 – 10 lbs: 140 mg (140 mg Spinosad + 2.3 mg Milbemycin Oxime)
- 10.1 – 20 lbs: 270 mg (270 mg Spinosad + 4.5 mg Milbemycin Oxime)
- 20.1 – 40 lbs: 560 mg (560 mg Spinosad + 9.3 mg Milbemycin Oxime)
- 40.1 – 60 lbs: 810 mg (810 mg Spinosad + 13.5 mg Milbemycin Oxime)
- 60.1 – 120 lbs: 1620 mg (1620 mg Spinosad + 27 mg Milbemycin Oxime)
- For dogs over 120 lbs: Consult your veterinarian for the appropriate combination of tablets.
What Are the Side Effects of Trifexis Medicines?
Like all medications, Trifexis may cause some side effects. The most common ones include:
- Vomiting (most frequently reported)
- Lethargy
- Diarrhea
- Loss of appetite
- Itching or skin irritation
In rare cases, more serious reactions such as neurological symptoms (tremors, seizures, or ataxia) may occur. Contact your veterinarian if you notice any unusual behavior.
Warnings & Precautions for Trifexis
- Not for Use in Puppies Under 8 Weeks Old – Trifexis is only approved for dogs 8 weeks and older, weighing at least 5 lbs.
- Use with Caution in Dogs with a History of Seizures – Spinosad may increase seizure risk in predisposed dogs.
- Test for Heartworms Before Starting – Dogs should undergo a heartworm test before beginning Trifexis to avoid potential complications.
- Not Safe for Cats or Other Animals – Trifexis is only for dogs and should never be given to other pets.
- Do Not Use With Certain Medications – Consult your vet before giving Trifexis alongside other flea treatments, dewormers, or ivermectin-based products.
Trifexis Chewable Tablets FAQs
Can Trifexis be used for puppies?
Trifexis is safe for puppies 8 weeks and older weighing at least 5 lbs. For smaller or younger puppies, consult your veterinarian for alternative parasite protection. If your puppy meets the weight requirement, check out Trifexis for Small Dogs (5-10 lbs).
Does Trifexis protect against ticks?
No, Trifexis does not kill ticks. If your dog is at risk for tick exposure, consider adding a tick-specific preventive alongside Trifexis. Ask your veterinarian about compatible tick control options to ensure complete parasite protection.
How should I store Trifexis tablets?
Store Trifexis at room temperature (68°F–77°F) in a dry place, away from moisture and direct sunlight. Keep it in its original packaging and out of reach of children and pets to prevent accidental ingestion.
Can I split a Trifexis tablet for smaller doses?
No, Trifexis tablets should not be split or crushed, as this may affect their effectiveness. Always use the correct weight-based dosage for your dog. If your dog is between weight categories, consult your vet or choose the appropriate Trifexis dosage based on their size.
What should I do if my dog vomits after taking Trifexis?
If vomiting occurs within one hour of administration, the tablet may not have been fully absorbed, and you may need to give another dose. Always provide Trifexis with food to minimize stomach upset. If vomiting persists, consult your veterinarian.
