Advantage Multi Topical Solution for Dogs 55.1-88 lbs, Blue

Monthly Topical 6-in-1 Parasite Protection for Large Dogs (55.1–88 lbs)

Product Description

Advantage Multi Topical Solution (Blue) is a prescription monthly spot-on for dogs and puppies between 55.1 and 88 pounds. It pairs Imidacloprid (10%) with Moxidectin (2.5%) to fight six parasites in one monthly tube. It covers heartworm prevention, flea control, sarcoptic mange, and intestinal worms including roundworms, hookworms, and whipworms. Dogs and puppies from 7 weeks old, weighing a minimum of 3 pounds, can be treated with this product.

Benefits

• Prevents Heartworm Disease: Moxidectin gets absorbed through the skin and keeps working all month, giving large dogs steady protection against heartworm larvae.
• Reduces Microfilariae Levels: One of the few topical preventives that helps lower circulating heartworm microfilariae in dogs already testing positive for the infection.
• Kills Fleas on Contact: Imidacloprid travels through the skin's natural oil layer and kills adult fleas before they ever get the chance to bite your dog.
• Stops Flea Infestations: Re-infesting fleas die within 3 to 5 minutes of contact, and egg-laying is disrupted, keeping full-blown infestations from taking hold.
• Controls Sarcoptic Mange: Targets the mites behind sarcoptic mange, which large dogs often pick up at grooming facilities, dog parks, or boarding kennels.
• Clears Roundworm Infections: Takes care of adult Toxocara canis and Toxascaris leonina roundworm infections in large dogs with each monthly dose.
• Clears Hookworm Infections: Works against Ancylostoma caninum, Ancylostoma braziliense, and Uncinaria stenocephala hookworms at multiple stages of their life cycle.
• Clears Whipworm Infections: Also handles Trichuris vulpis whipworm infections, rounding out full intestinal parasite coverage in one spot-on application.
• Holds Up Against Water: Protection stays effective 60 minutes after your dog goes for a swim and 90 minutes after a bath, great for active large breeds.
• Flexible if a Dose is Late: If you miss the monthly window by a few days, simply apply right away and continue your regular monthly schedule from there.
• Safe From 7 Weeks Old: Cleared for use in puppies as young as 7 weeks, provided they weigh at least 3 pounds at the time of application.

Ingredients

Composition Table

Total volume: 4 mL

How to Use

Directions for Use

• Prescription Only: This is an FDA-licensed prescription product and can only be dispensed through or under the direction of a licensed veterinarian.
• Apply Once a Month: Empty the full contents of one tube onto your dog's skin once every month, ideally on the same date each time.
• Correct Monthly Dose: The right amount is at least 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin per application.
• Step 1 – Open the Tube: Take one applicator tube out of the packaging. Keep it pointing upward and pull the cap off.
• Step 2 – Break the Seal: Flip the cap around and press its other end firmly onto the tip of the tube. Twist until the seal breaks, then remove the cap fully.
• Step 3 – Find the Right Spot: Ask your dog to stand still. Separate the fur between the shoulder blades until you can see the skin clearly.
• Step 4 – Apply Along the Back: Press the tip against the skin and squeeze the full contents across three or four spots along the backline, starting at the base of the neck and moving toward the upper back. Choose spots your dog cannot reach to lick. Do not apply so much in one spot that it drips off the side.
• Skip Broken or Irritated Skin: Do not apply the solution to any area of skin that is cut, raw, or inflamed in any way.
• For Mange Treatment: A single monthly dose is the standard approach; your veterinarian may recommend a second application the following month if needed.
• For Dogs Over 110 lbs: Your veterinarian will advise on the right combination of tubes to reach the correct total dose for your dog's weight.
• If You Miss a Dose: Apply as soon as you remember and carry on with the regular monthly schedule from that point; never apply two doses at once.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any medication for your pet.

Additional Information

Precautions

• Heartworm Test First: Dogs should be screened for heartworm before the first dose is given, since adult heartworm infections are not addressed by this product.
• Adult Heartworms Not Treated: This product does not kill adult heartworms; dogs with a positive diagnosis should receive adulticide therapy before beginning use.
• Never Give by Mouth: Swallowing this solution can cause serious harm including tremors, incoordination, excessive drooling, and dilated pupils in dogs.
• Prevent Licking After Application: Keep your dog from reaching its own treated area or another treated pet's skin for a minimum of 30 minutes post-application.
• Keep Children at a Distance: Children should not touch the treated area of skin for at least two hours after the product has been applied.
• For Dogs Only: This formulation must not be used on cats; a separate cat-specific version of this product is available through your veterinarian.
• Protect the Eyes: If the solution makes contact with the eyes, hold the eyelids open, rinse well with water, and speak with your veterinarian promptly.
• Minimum Age and Weight: This product has not been found safe for puppies or dogs younger than 7 weeks or weighing under 3 pounds.
• Caution in Unwell Dogs: Sick, underweight, or weakened large dogs need extra consideration before use; check with your veterinarian before applying.
• Breeding and Lactating Dogs: No safety data exists for pregnant or nursing dogs; your veterinarian should assess the risk before use in these animals.
• Gap Before Adulticide Treatment: Using this product on the same day as heartworm adulticide therapy has not been studied; your veterinarian should set the timing.
• Worm Counts Can Vary: In a small number of heartworm-positive dogs, microfilariae levels may not drop as expected; regular veterinary monitoring remains essential.
• Clean Hands After Use: Wash your hands well with soap and water every time you finish applying the product to your dog.

Possible Side Effects

• Skin Reactions at Application Site: Mild itching, flaking, or visible residue around where the product was applied can occur and usually clears up on its own.
• Stomach-Related Signs: Some dogs may show loose stools, vomiting, reduced appetite, or traces of blood in their stool after receiving treatment.
• Low Energy: Some dogs appear more tired than usual or sleep longer periods following their monthly application of this product.
• Unusual Behaviour: Restlessness, excessive self-grooming, hiding, or pacing has been reported after application; speak to your vet if it continues.
• If the Product is Swallowed: Licking the treated area can lead to serious neurological signs; take your dog to an emergency vet without delay if this happens.
• Skin Infection Near the Site: In some cases, a skin infection (pyoderma) developed at or close to where the product was applied during field safety testing.
• Rare but Serious Reactions: Sudden facial swelling, hives, pale gums, seizures, or collapse are uncommon but require urgent emergency veterinary care.
• Excess Drooling: Some dogs produce more saliva than usual within the first hour of treatment; let your vet know if this does not settle down.

Storage Information

• Correct Temperature Range: Keep stored between 39°F (4°C) and 77°F (25°C); do not let the product freeze or sit in excessive heat.
• Out of Reach at All Times: Store this prescription medication somewhere children and other pets cannot access it to avoid accidental exposure.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What parasites does Advantage Multi (Blue) protect large dogs against?

Ans: Advantage Multi (Blue) covers six parasites in one tube: heartworm larvae, circulating microfilariae in already-infected dogs, adult fleas, flea infestations, sarcoptic mange mites, and intestinal worms including roundworms, hookworms, and whipworms. It does not cover ticks.

Q2: How does the Blue Box for 55.1–88 lb dogs differ from the Red Box for smaller dogs?

Ans: The Blue Box holds 400 mg imidacloprid and 100 mg moxidectin in a 4 mL tube. The Red Box holds 250 mg and 62.5 mg in a 2.5 mL tube. Both provide the same protection. Always pick the box that fits your dog's current weight.

Q3: How does this spot-on treatment compare to oral heartworm preventives for large dogs?

Ans: This topical solution absorbs through the skin and provides month-long heartworm protection without a tablet. It also handles fleas, intestinal worms, and sarcoptic mange in the same application, and it is one of the few products that can reduce microfilariae levels in heartworm-positive dogs.

Q4: What should I do if my large dog licks the treated area?

Ans: Swallowing this product can cause muscle tremors, poor coordination, drooling, and dilated pupils. Get your dog to a veterinarian or emergency clinic straight away. After applying, keep your dog away from the treated spot for at least 30 minutes and separate it from other pets during that time.

Q5: Is Advantage Multi (Blue) safe to use if my large dog has already been diagnosed with heartworms?

Ans: This product cannot kill adult heartworms. Dogs with a confirmed infection should complete adulticide treatment first. However, it is one of the few topicals indicated to reduce microfilariae in heartworm-positive dogs. Your veterinarian should plan the timing of both treatments carefully.

Clinical Research

https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=3fc1a42b-6576-4890-aa0c-5c0eb903c85a

https://animaldrugsatfda.fda.gov/adafda/app/search/public/document/downloadFoi/804