Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Monthly 5-in-1 Spot-On for Heartworm, Fleas and Parasites in Cats and Ferrets
Product Description
Barrier Topical Solution (Orange Box) is an FDA-approved, prescription-only monthly spot-on for cats 9 weeks or older weighing 5.1 to 9 lbs, and for ferrets at least 2 lbs. Each 0.4 mL tube delivers 10% imidacloprid and 1% moxidectin. It prevents heartworm, kills fleas, treats ear mites, and controls roundworm and hookworm infections in cats, and prevents heartworm and treats fleas in ferrets.
Benefits
- Prevents Heartworm Disease: Moxidectin prevents Dirofilaria immitis larval development into adult heartworms when applied once monthly to cats and ferrets.
- Kills Adult Fleas: Imidacloprid kills adult fleas starting within 12 hours of application, providing fast-acting flea relief for cats and ferrets.
- Treats Ear Mites in Cats: Treats and controls Otodectes cynotis ear mite infestations in cats with a single monthly topical application.
- Treats Roundworms in Cats: Treats and controls Toxocara cati intestinal roundworm infections in cats effectively with each monthly dose.
- Treats Hookworms in Cats: Treats and controls Ancylostoma tubaeforme intestinal hookworm infections in cats effectively with every monthly application.
- Only Ferret-Safe Size: The 0.4 mL Orange Box is the sole Barrier tube size approved for safe and effective use in ferrets.
- Same Ingredients, Better Value: Contains the same active ingredients as Advantage Multi for Cats, offering equivalent five-in-one parasite protection.
- Made in the USA: Manufactured and packaged in the USA from a registered FDA facility, ensuring quality and regulatory compliance.
Ingredients
Composition Table
| Ingredient | Quantity |
| Imidacloprid | 10% (40 mg per 0.4 mL tube) |
| Moxidectin | 1% (4 mg per 0.4 mL tube) |
Other Ingredients
Benzyl alcohol, Propylene carbonate
How to Use
Directions for Use — Cats
- Prescription Required: This medication is restricted in the United States and must be used with a veterinarian's prescription or guidance.
- Open the Tube Correctly: Position the tube vertically, open it by twisting the cap, and use it while the cap stays attached.
- Apply at Neck Base: Part the fur at the back of the cat's neck until the skin is visible, then place the tube tip on skin.
- Squeeze Entire Contents: Apply the entire tube contents onto the exposed skin in one spot and allow the area to dry naturally.
- Lift Tube Before Releasing: Remove the tube from the skin before releasing pressure to prevent the solution from being drawn back in.
- Apply Once Monthly: Administer every 30 days for continuous heartworm prevention, flea control, and parasite protection in cats.
Directions for Use — Ferrets
- Ferret Weight Minimum: Apply the entire 0.4 mL Orange Box tube once monthly only to ferrets weighing at least 2 lbs.
- Apply Between Shoulder Blades: Apply the entire tube contents between the shoulder blades of the ferret as directed by your veterinarian.
- Prevent Post-Application Licking: Keep cats and ferrets from licking the application site for 30 minutes and separate pets until the area dries.
- Test for Heartworm First: Test all cats and ferrets for existing heartworm disease before beginning any heartworm prevention protocol with Barrier.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- Minimum Age and Weight: Do not use in cats under 9 weeks of age or weighing less than 2 lbs.
- Ferret Tube Size Critical: Only the 0.4 mL Orange Box is safe for ferrets; the smaller tube underdoses and the larger tube risks overdose.
- Ferret Weight Limitation: The effectiveness of Barrier in ferrets weighing over 4.4 lbs has not been established; consult your veterinarian accordingly.
- Sick or Debilitated Animals: Never apply Barrier to sick, debilitated, or underweight cats or ferrets regardless of their age or body weight.
- Breeding, Pregnant, Lactating Animals: Do not use in breeding, pregnant, or lactating cats or ferrets without first speaking to a veterinarian, as safety hasn't been established.
- Geriatric Cats: Use with caution in older cats with undiagnosed conditions; prolonged lethargy has been reported in some thin geriatric cats.
- Licking Prevention Critical: Accidental ingestion or licking of the product may cause hypersalivation, tremors, vomiting, and decreased appetite in cats and ferrets.
- Bathing Efficacy Not Evaluated: Effectiveness against heartworm after bathing has not been evaluated; avoid bathing close to application time.
- Eye Irritant for Humans: Keep it away from your eyes, and wash your hands carefully with soap and warm water after every use.
Possible Side Effects
- Hypersalivation: Excessive drooling can occur if the cat or ferret grooms the treated area; correct placement at the head base reduces risk.
- Vomiting and Decreased Appetite: Vomiting and reduced appetite have been reported when the product is accidentally ingested through self-grooming by cats.
- Tremors: Neurological tremors have been reported following accidental ingestion of the product; contact your veterinarian immediately if this occurs.
- Ferret Site Reactions: Pruritus, scabbing, redness, wounds, and inflammation at the treatment site have been reported in ferrets but resolved without therapy.
- Stiff or Matted Hair: Stiff, oily hair at the application site may appear temporarily; this is cosmetic and does not affect product safety.
- Human Adverse Reactions: Human exposure may cause headache, dizziness, and skin redness, burning, or tingling; seek medical attention if these symptoms occur.
Storage Information
- Store at Cool Temperature: Store between 4°C (39°F) and 25°C (77°F); avoid exposure to excess heat or cold at all times.
- Secure Storage Required: Store this prescription product securely out of reach of children and other animals at all times.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What does Barrier Topical Solution (Orange Box) treat in cats and ferrets?
Ans: For cats weighing 5.1 to 9 lbs, Barrier Orange Box prevents heartworm, kills adult fleas, treats ear mites, and controls roundworm and hookworm infections monthly. For ferrets weighing at least 2 lbs, it prevents heartworm disease and treats adult flea infestations with one monthly application.
Q2: Why is the Orange Box the only Barrier size approved for ferrets?
Ans: Only the 0.4 mL Orange Box provides the correct dose for ferrets. The 0.23 mL tube delivers too little to be effective, while the 0.8 mL tube contains more than double the appropriate ferret dose, posing a serious overdose risk.
Q3: Does the cat and ferret spot-on treat ear mites and worms in ferrets?
Ans: No. For ferrets, Barrier is only approved for heartworm prevention and adult flea treatment. Ear mite, roundworm, and hookworm indications apply to cats only. If your ferret needs treatment for ear mites or intestinal parasites, consult your veterinarian for a ferret-specific option.
Q4: How does the Orange Box differ from the Purple Box for cats?
Ans: The Orange Box contains 0.4 mL delivering 40 mg imidacloprid and 4 mg moxidectin, suited for cats weighing 5.1 to 9 lbs. The Purple Box contains 0.8 mL delivering double the dose for cats weighing 9.1 to 18 lbs. Both provide identical five-in-one parasite protection.
Q5: Is the monthly ferret and cat spot-on safe for pregnant or breeding animals?
Ans: Safety for Barrier has not been confirmed in pregnant, lactating, or breeding cats or ferrets. If your pet is pregnant, nursing, or part of a breeding program, always speak with your veterinarian before starting parasite prevention to ensure the best option is selected.
Clinical Research
Imidacloprid – Flea Control Mechanism (NPIC)
Moxidectin – Antiparasitic Applications in Skin Disease (MSD Veterinary Manual)
Feline Heartworm Disease Overview (American Heartworm Society)