Barrier Topical Solution for Dogs, 20.1-55 lbs (Pink)

Monthly 6-in-1 Spot-On for Heartworm, Fleas and Parasites in Medium Dogs

Product Description

Barrier Topical Solution (Pink/Red Box, 20.1 to 55 lbs) is an FDA-approved, prescription-only monthly spot-on for dogs and puppies aged 7 weeks+ weighing 20.1 to 55 lbs. Each 2.5 mL tube delivers 10% imidacloprid and 2.5% moxidectin, the same active ingredients as Advantage Multi for Dogs. One monthly dose prevents heartworm, treats microfilariae, kills adult fleas, treats intestinal worms, and controls sarcoptic mange in medium dogs.

Benefits

• Prevents Heartworm Disease: Moxidectin prevents Dirofilaria immitis larval development into adult heartworms when applied once monthly to medium dogs.
• Treats Circulating Microfilariae: Unlike many other preventives, Barrier for Dogs also treats existing Dirofilaria immitis circulating microfilariae in heartworm-positive dogs.
• Kills Adult Fleas: Imidacloprid kills adult fleas fast, providing effective flea treatment and preventing flea infestations with each monthly dose.
• Treats Intestinal Worms: Effectively treats and controls intestinal infections caused by hookworms, roundworms, and whipworms in medium dogs.
• Treats Sarcoptic Mange: Treats and controls sarcoptic mange (Sarcoptes scabiei) infestations in medium dogs with each monthly topical application.
• Higher Moxidectin Concentration: Contains 2.5% moxidectin, significantly higher than the cat formulation, providing the dose required for medium dogs.
• Same Ingredients, Better Value: Contains the same active ingredients as Advantage Multi for Dogs, offering equivalent six-in-one parasite protection.
• Made in the USA: Manufactured and packaged in the USA from a registered FDA facility, ensuring quality and regulatory compliance.

Ingredients

Composition Table

Other Ingredients

Benzyl alcohol, Propylene carbonate

How to Use

Directions for Use

• Prescription Required: This product must be used only when prescribed or instructed by a licensed veterinarian, according to U.S. law.
• Dog Must Be Standing: Have your medium dog standing throughout the entire application process to ensure even solution distribution.
• Open the Tube Correctly: Hold the tube upright, turn the cap to break the seal, and keep the cap on while applying.
• Apply Along the Backline: Part the hair and apply the entire contents at 3 to 4 spots along the top of the backline from the neck.
• Squeeze Entire Contents: Apply directly onto the skin at each spot and allow the area to dry naturally without rubbing the product in.
• Lift Tube Before Releasing: Remove the tube from the skin before releasing pressure to prevent the solution from being drawn back in.
• Apply Once Monthly: Administer every 30 days for continuous heartworm prevention, flea control, and parasite protection throughout the year.
• Prevent Post-Application Licking: Keep the dog from licking application sites for 30 minutes and separate treated animals from other pets.
• Test for Heartworm First: Test all dogs for existing heartworm infection before starting Barrier; consult your veterinarian about adulticide treatment if needed.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Minimum Age and Weight: Do not use in dogs less than 7 weeks of age or weighing less than 3 lbs.
• Never Use on Cats: This dog formulation contains 2.5% moxidectin, far higher than the cat formula, and can be fatal to cats.
• Do Not Give Orally: Never administer this product orally; ingestion may cause depression, salivation, dilated pupils, incoordination, panting, and muscle tremors.
• Avermectin-Sensitive Dogs: In MDR1-mutation dogs, accidental oral ingestion may cause severe reactions including coma and death; use with extreme caution.
• Sick or Debilitated Dogs: Use with caution in sick, debilitated, or underweight animals and always seek veterinary guidance before applying Barrier.
• Breeding, Pregnant, Lactating Dogs: Safety has not been established in breeding, pregnant, or lactating dogs; consult your veterinarian before use.
• Keep Children Away: Children should not come into contact with the application sites for two hours after applying the product.
• Eye Irritant for Humans: If eye exposure happens, flush the eyes with water for 15 minutes and always wash hands thoroughly after handling.

Possible Side Effects

• Hematochezia and Diarrhea: Blood in stool and diarrhea have been reported in field studies; contact your veterinarian if these occur.
• Vomiting and Inappetence: Vomiting and reduced appetite have been reported following treatment in field safety studies with dogs.
• Lethargy and Pyoderma: Lethargy and skin infection at the application site have been reported in dogs during field studies.
• Neurological Signs: Weakness, depression, and unsteadiness have been reported in dogs after application; contact your veterinarian immediately if observed.
• Application Site Reactions: Localized itching and hyperkeratosis at the application site have been reported in dogs with pre-existing flea allergy dermatitis.

Storage Information

• Store at Cool Temperature: Store between 4°C (39°F) and 25°C (77°F); avoid exposure to excess heat or cold at all times.
• Secure Storage Required: Store this prescription product securely out of reach of children and other animals at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What does Barrier Topical Solution (Pink/Red Box) treat and prevent in medium dogs?

Ans: Barrier Pink/Red Box is a monthly 6-in-1 spot-on for dogs 20.1 to 55 lbs that prevents heartworm, treats circulating microfilariae, kills adult fleas, treats flea infestations, controls hookworms, roundworms, and whipworms, and treats sarcoptic mange in dogs and puppies 7 weeks or older.

Q2: Why is the solution applied at multiple spots for medium dogs?

Ans: For dogs over 20 lbs, applying the full tube in one spot causes product pooling and reduces absorption. Distributing the solution at 3 to 4 spots along the backline from the neck to the upper back ensures better skin contact and complete therapeutic coverage across the dog's body.

Q3: Can the medium dog spot-on treat a heartworm-positive dog?

Ans: Yes. Barrier for Dogs is indicated for treating Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. It does not eliminate adult heartworms, so veterinarians may also recommend adulticide treatment to remove existing adult worms alongside the microfilariae treatment protocol.

Q4: How does the Pink/Red Box differ from the Teal Box for dogs?

Ans: The Pink/Red Box contains 2.5 mL delivering 250 mg imidacloprid and 62.5 mg moxidectin for dogs weighing 20.1 to 55 lbs. The Teal Box contains 1.0 mL delivering 100 mg imidacloprid and 25 mg moxidectin for dogs 9.1 to 20 lbs. Both provide identical six-in-one protection.

Q5: Is the medium dog monthly spot-on safe for pregnant or lactating dogs?

Ans: Barrier for Dogs has not been tested for safety in dogs that are pregnant, lactating, or breeding. If your medium dog is pregnant, nursing, or intended for breeding, always consult your veterinarian before starting any parasite prevention program to determine the safest and most appropriate option.

Clinical Research

Imidacloprid – NPIC (National Pesticide Information Center)

Dirofilaria immitis (Heartworm) – University of Saskatchewan (WCVM)

Moxidectin – ScienceDirect

Sarcoptic Mange – VCA Animal Hospitals