Barrier Topical Solution for Dogs, 3-9 lbs, (Green)

Monthly 6-in-1 Spot-On for Heartworm, Fleas and Parasites in Extra-Small Dogs

Product Description

Barrier Topical Solution (Green Box) is an FDA-approved, prescription-only monthly spot-on for dogs and puppies 7 weeks or older weighing 3 to 9 lbs. Each 0.4 mL tube contains 10% imidacloprid and 2.5% moxidectin. Applied monthly on the area between the shoulders, it protects against heartworm, kills fleas, treats circulating microfilariae, clears intestinal worms, and eliminates sarcoptic mange in extra-small dogs.

Benefits

• Prevents Heartworm Disease: Moxidectin stops Dirofilaria immitis larvae from developing into adult heartworms with one monthly application in extra-small dogs.
• Treats Circulating Microfilariae: Goes beyond prevention by also treating existing Dirofilaria immitis microfilariae circulating in the blood of heartworm-positive dogs.
• Kills Adult Fleas: Imidacloprid wipes out adult fleas on contact within 12 hours, delivering fast relief and stopping infestations before they spread.
• Treats Intestinal Worms: Clears and controls hookworm, roundworm, and whipworm intestinal infections in extra-small dogs with every monthly dose.
• Treats Sarcoptic Mange: Resolves Sarcoptes scabiei mange infestations in extra-small dogs through consistent monthly topical use.
• Single-Spot Application: The full tube is dropped in one spot between the shoulder blades, making monthly dosing fast and simple for tiny dogs.
• Same Ingredients, Better Value: Delivers the same 10% imidacloprid and 2.5% moxidectin formula as Advantage Multi for Dogs at a more accessible price.
• Made in the USA: Made and packaged in the USA at a registered FDA facility, with a convenient twist-to-open applicator included.

Ingredients

Composition Table

Other Ingredients

Benzyl alcohol, Propylene carbonate

How to Use

Directions for Use

• Prescription Required: US Federal law limits this product to use by or on the order of a licensed veterinarian only.
• Dog Must Be Standing: Keep your dog standing through the full application to help the solution sit and absorb properly on the skin.
• Open the Tube Correctly: Point the tube upward, twist the cap until the seal breaks, and leave the cap on throughout the application.
• Apply Between Shoulder Blades: Part the coat between the shoulder blades to expose skin, then press the tube tip directly onto the skin.
• Squeeze Entire Contents: Empty the full tube onto that one spot and let it air dry completely without rubbing the product in.
• Lift Tube Before Releasing: Pull the tube away from skin before easing pressure to keep the solution from being drawn back in.
• Apply Once Monthly: Repeat every 30 days to keep heartworm prevention, flea control, and broad parasite protection continuously active.
• Prevent Post-Application Licking: Stop the dog from licking the treated spot for 30 minutes and keep other pets away until fully dry.
• Test for Heartworm First: Have all dogs tested for heartworm before starting Barrier; ask your vet about adulticide therapy if your dog tests positive.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Minimum Age and Weight: Do not use on dogs under 7 weeks old or weighing less than 3 lbs.
• Never Use on Cats: The 2.5% moxidectin in this dog formula far exceeds safe cat levels and can be fatal if applied to them.
• Do Not Give Orally: Swallowing this product can trigger serious reactions in dogs including drooling, dilated pupils, incoordination, panting, and tremors.
• Avermectin-Sensitive Dogs: Dogs with the MDR1 gene mutation, common in herding breeds, risk coma or death if this product is accidentally swallowed.
• Sick or Debilitated Dogs: Do not apply Barrier to sick, weak, or underweight dogs without first getting clear guidance from your veterinarian.
• Breeding, Pregnant, Lactating Dogs: Safety in breeding, pregnant, or nursing dogs has not been confirmed; always check with your veterinarian before use.
• Keep Children Away: Keep children away from the treated area for at least two hours after applying the product to your dog.
• Eye Irritant for Humans: If the product contacts your eyes, rinse with water for 15 minutes and wash hands thoroughly after every use.

Possible Side Effects

• Hematochezia and Diarrhea: Blood in the stool and loose stools have been reported in field studies; reach out to your vet right away.
• Vomiting and Inappetence: Stomach upset and reduced appetite have been noted in dogs during field safety testing after treatment.
• Lethargy and Pyoderma: Low energy and skin infection at the treated site have been observed in some dogs in field studies.
• Neurological Signs: Weakness, low mood, and unsteady movement have occurred in dogs post-application; call your vet immediately if you notice these.
• Application Site Reactions: Dogs with existing flea allergy dermatitis may develop localized itching and thickened skin at the treated area.

Storage Information

• Store at Cool Temperature: Keep between 4°C (39°F) and 25°C (77°F) and protect from both excessive heat and cold at all times.
• Secure Storage Required: Lock this prescription product away from children and other animals in a safe, inaccessible location at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What does Barrier Topical Solution (Green Box) protect extra-small dogs against?

Ans: Barrier Green Box is a monthly 6-in-1 spot-on for dogs 3 to 9 lbs. It prevents heartworm, treats microfilariae, kills adult fleas, controls flea infestations, treats hookworms, roundworms, and whipworms, and clears sarcoptic mange in puppies and dogs at least 7 weeks old.

Q2: How does the Green Box differ from the Teal Box for small dogs?

Ans: The Green Box is the smallest Barrier dog tube at 0.4 mL, delivering 40 mg imidacloprid and 10 mg moxidectin for dogs 3 to 9 lbs. The Teal Box holds 1.0 mL for dogs 9.1 to 20 lbs. Both provide the same six-in-one protection.

Q3: Can the Green Box be used in puppies weighing less than 3 lbs?

Ans: No. Barrier Green Box must not be used in puppies under 3 lbs or younger than 7 weeks, as safety below these thresholds has not been established. If your puppy is very young or underweight, speak with your veterinarian before starting any topical parasite prevention program.

Q4: Can this extra-small dog spot-on be used on a heartworm-positive dog?

Ans: Yes. Barrier for Dogs is one of the few monthly topicals approved to treat Dirofilaria immitis microfilariae in heartworm-positive dogs. Since it does not kill adult heartworms, your veterinarian may also prescribe adulticide therapy to remove the existing adult worm burden.

Q5: Is the Green Box monthly spot-on safe during pregnancy or nursing?

Ans: Safety in breeding, pregnant, or nursing dogs has not been established for Barrier. If your dog is expecting, currently nursing a litter, or being used for breeding, speak with your veterinarian first to find the safest and most suitable parasite prevention option available.

Clinical Research

Imidacloprid – NPIC (National Pesticide Information Center)

Dirofilaria immitis (Heartworm) – University of Saskatchewan (WCVM)

Moxidectin – ScienceDirect

Sarcoptic Mange – VCA Animal Hospitals