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Product title
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Product title
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Product title
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$19.99 | $24.99
FDA-Approved NK1 Antiemetic Injectable Solution for Dogs and Cats
Product Description
Cerenia (Maropitant Citrate) Injectable Solution 10 mg/mL is an FDA-approved prescription antiemetic for subcutaneous or intravenous use in dogs and cats, supplied in 20 mL amber glass vials. Maropitant is an NK1 receptor antagonist that blocks substance P, the neurotransmitter that triggers vomiting, in the central nervous system. It prevents and treats acute vomiting in dogs and treats vomiting in cats.
Benefits
- Antiemetic Action: Blocks substance P at NK1 receptors in the brain, stopping both central and peripheral vomiting causes.
- High Bioavailability: Reaches 91% bioavailability in dogs and 91.3% in cats after subcutaneous injection with each dose.
- Proven in Dogs: In a US field study, only 21.4% of Cerenia-treated dogs vomited versus 50% in the placebo group.
- Proven in Cats: Only 1.8% of treated cats vomited in the 24 hours after treatment compared to 18.5% of placebo cats.
- Chemo Vomiting Prevention: In a chemotherapy study, 94.9% of Cerenia-treated dogs did not vomit versus just 4.9% of placebo dogs.
- Reduces Injection Discomfort: Using the chilled product for subcutaneous injections can lower the pain response at the injection site.
Ingredients
Active Ingredients
Maropitant (as Maropitant Citrate): 10 mg per mL
Inactive Ingredients
Sulphobutylether-beta-cyclodextrin 63 mg/mL, meta-cresol 3.3 mg/mL, water for injection
How to Use
Directions for Use
- Prescription Required: Cerenia Injectable Solution is federally restricted and must only be given under a licensed veterinarian's direct order.
- Young Dogs SC Only: Give SC at 1 mg/kg (0.1 mL/kg) once daily for up to 5 days; IV not cleared at this age.
- Dogs SC or IV: Give SC or IV at 1 mg/kg once daily over 1 to 2 minutes, up to 5 days.
- Cats SC or IV: Give SC or IV at 1 mg/kg once daily over 1 to 2 minutes, up to 5 days.
- Pre-Chemotherapy Dosing: Give IV or SC at 1 mg/kg once, 45 to 60 minutes before chemotherapy or emetogenic treatment begins.
- Use Chilled Product: Always use refrigerated solution for SC injections, as the cooler temperature helps reduce discomfort at the site.
- Transition to Tablets: Once vomiting settles, Cerenia Tablets at 2 mg/kg daily can maintain prevention in dogs as the vet directs.
- Find Underlying Cause: Always work to identify the root cause of vomiting; reassess the case if vomiting continues despite ongoing treatment.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- GI Obstruction Caution: Do not use in pets that may have swallowed toxins or have a gut blockage without a full vet evaluation first.
- Liver Disease Caution: Pets with poor liver function break down this drug differently and will need careful watching throughout the full treatment course.
- Highly Protein Bound: This drug competes for protein binding in the blood, so use carefully alongside NSAIDs, heart medications, or seizure drugs.
- Breeding Animal Caution: This product has not been tested in pregnant, nursing, or breeding animals; check with your vet before giving it to any of these pets.
- Young Puppy Caution: Puppies younger than 11 weeks showed bone marrow changes in studies; no such changes were seen in those 16 weeks and older.
- Human Handling Precautions: Keep away from skin and eyes; if eye contact happens, rinse thoroughly with water for a full 15 minutes and get medical help.
Possible Side Effects
In Dogs:
- Injection Site Pain: Discomfort or vocalization at the injection site is common; chilled product for SC use may help reduce this.
- Depression and Lethargy: Tiredness and low mood have been reported in post-approval data and field study results for dogs receiving Cerenia.
- Anorexia and Hypersalivation: Reduced appetite and excessive drooling have been noted; contact your vet if either issue does not ease up.
- Serious Reactions: Facial swelling, seizures, fever, and breathing trouble have been reported; get emergency veterinary care right away.
In Cats:
- Injection Discomfort: During field studies, a number of cats resisted injection by backing away or vocalizing; keeping the solution cold before use may help.
- Depression and Anorexia: Tiredness, poor appetite, and drooling are the side effects cats most commonly show; keep a close eye on your cat after dosing.
- Neurological Signs: Some cats have shown shaking, loss of balance, seizures, or breathing difficulty after use; reach out to your vet if this happens.
Storage Information
- Refrigerated Storage: Keep refrigerated to maintain stability and preserve the formulation's binding properties, which break down once warmed.
- Keep Out of Reach: Store the 20 mL amber vial away from children and all pets to prevent accidental contact or ingestion.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What is Cerenia Injectable Solution used for in dogs and cats?
Ans: Cerenia Injectable Solution 10 mg/mL prevents and treats acute vomiting in dogs, including vomiting brought on by chemotherapy. In cats, it is used to treat vomiting. It can be given by subcutaneous injection or through an IV line, depending on the age and species of the patient.
Q2: How does Cerenia maropitant injection stop vomiting in dogs and cats?
Ans: Maropitant works by blocking NK1 receptors in the brain's vomiting center, shutting down the substance P pathway that sets off the vomiting reflex. This stops both central and peripheral vomiting triggers, including those caused by apomorphine, cisplatin, and other emetogenic drugs.
Q3: What is the correct Cerenia injectable dose for dogs and cats?
Ans: Dogs and cats 4 months and older receive 1 mg/kg (0.1 mL/kg) once daily for up to 5 days by SC or IV over 1 to 2 minutes. For dogs between 2 and 4 months old, the same dose applies but only the subcutaneous route is cleared for this younger age group.
Q4: Can Cerenia Injectable Solution interact with other medications in dogs and cats?
Ans: Yes. Maropitant is highly protein bound (99.5% in dogs, 99.1% in cats), which means it may interact with other protein-bound drugs including NSAIDs, cardiac medications, anticonvulsants, and behavioral drugs. Always inform your veterinarian of all current medications before administering Cerenia to avoid potential interactions.
Q5: Why should Cerenia maropitant citrate injection be stored in the refrigerator?
Ans: Cold storage keeps the binding between sulphobutylether-beta-cyclodextrin and maropitant intact, which is key to the product's stability. Using the chilled solution for SC injections also lowers discomfort at the injection site, as this binding breaks down quickly once the vial reaches room temperature.