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Comfortis Chewable Tablet for Dogs (20.1-40 lbs) & Cats (12.1-24 lbs)

$20.84

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Prescription Required

Elanco SKU: CA4224Y07AM-1

Size: 1 Chewable Tablet (1 month supply)
Free Shipping on Prescription Pharmacy orders above $49

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Comfortis Chewable Tablets for Dogs (20.1–40 lbs) & Cats (12.1–24 lbs)

Fast-Acting Flea Treatment from HardyPaw

Comfortis Chewable Tablets are fast-acting, vet-prescribed oral flea medications designed for medium-sized dogs (20.1–40 lbs) and cats (12.1–24 lbs). With its powerful active ingredient, spinosad, Comfortis begins killing fleas within 30 minutes and provides month-long protection. This FDA-approved, beef-flavored chewable is a great alternative to messy topical treatments and is safe for multi-pet households.

Perfect for pets suffering from flea infestations, flea allergy dermatitis (FAD), or those living in areas with year-round flea presence, Comfortis offers reliable and convenient flea control with minimal fuss.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Also Available in Other Comfortis Weight Ranges

Comfortis Chewable Tablets come in multiple weight-specific options to ensure safe and effective flea protection for both dogs and cats. Select the right strength based on your pet’s weight for maximum efficacy:

Pro Tip: For best results, match the product to your pet’s exact weight range and administer monthly. Always consult your veterinarian if you're unsure which variant is right for your pet.

What Are the Benefits of Comfortis for Dogs & Cats (20.1–40 lbs /12.1–24 lbs)?

Comfortis outshines many traditional flea treatments with these standout benefits:

  • Starts killing fleas within 30 minutes of ingestion—rapid relief from itching and irritation
  • Kills adult fleas before they can lay eggs, breaking the flea life cycle
  • Protects for 30 full days with just one chewable tablet
  • No residue, mess, or odor like topical treatments
  • Beef-flavored chew is easy to administer with or without food
  • Waterproof—bathing or swimming won’t affect its efficacy
  • Reduces flea reinfestation risk when used in all household pets

Who Can Use Comfortis Tablets?

Pet Type

Minimum Age

Minimum Weight

Dogs

14 weeks

5 lbs

Cats

14 weeks

4.1 lbs

⚠️ This product is specifically dosed for dogs weighing 20.1–40 lbs and cats weighing 12.1–24 lbs.

Dosage and Administration of Comfortis Flea Treatment

Comfortis should be administered orally once a month, with food for improved absorption. Follow the weight-specific dosage carefully:

Weight (lbs)

Spinosad (mg)

Tablets to Administer

20.1 – 40

560 mg

One

Key Dosage Guidelines:

  • Administer with a meal or immediately afterward
  • If vomiting occurs within one hour, redose with a full tablet
  • If a dose is missed, resume a regular monthly schedule
  • Begin treatment one month before flea season, or continue year-round in endemic areas
  • Treat all pets in the household for complete flea control

Always consult your veterinarian for exact dosage instructions depending on your pet’s health status.

How to Give Comfortis to Finicky Eaters?

Some cats and dogs can be picky with oral medications. Here's how to administer Comfortis more easily:

  • Offer just before feeding—most pets accept it this way
  • Hide in soft food or a treat pouch
  • Use a pill pocket or moldable treat
  • Crush and mix with wet food (only if your vet approves)

🐾 Tip: Try giving a small treat immediately after to create a positive association.

What Is in Comfortis? (Ingredients Breakdown)

  • Spinosad (560 mg): Kills fleas by overstimulating their nervous system via nicotinic acetylcholine receptors (nAChRs), causing paralysis and death. Derived from the soil bacterium Saccharopolyspora spinosa, it's environmentally friendly.

Are There Any Side Effects of Comfortis?

In Dogs:

  • Most common: Vomiting
  • Others: Lethargy, loss of appetite, diarrhea, trembling, drooling, seizures (rare)
  • Caution: Use with care in pregnant females or dogs with epilepsy

In Cats:

  • Most common: Vomiting
  • Others: Lethargy, diarrhea, weight loss, decreased appetite
  • Not evaluated in breeding or lactating cats

Overdose Risks:

In the event of accidental overdose, contact your vet or nearest emergency animal hospital immediately.

What Precautions Should Be Taken When Using Comfortis?

  • Not for human use—keep out of reach of children
  • Do not split tablets between pets
  • Use correct weight-specific dosage
  • Avoid use with high doses of ivermectin unless directed by your vet
  • Comfortis has not been tested in breeding males or lactating animals
  • Store between 68–77°F (20–25°C); excursions allowed from 59–86°F (15–30°C)

When Is the Best Time of Year to Start Comfortis?

Start Comfortis one month before flea season begins. However, if you live in warmer regions or areas with year-round flea activity, continuous monthly dosing is recommended.

  • Cold climates: Start in early spring, continue through fall
  • Warm or humid areas: Use Comfortis year-round
  • Indoor pets: Still at risk, especially in multi-pet homes

Comfortis helps prevent outbreaks before they start, making it easier to maintain a flea-free home.

Shipping & Returns

Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Comfortis Flea Tablets for Dogs and Cats FAQs 

Is Comfortis safe for dogs with food allergies?

Comfortis contains a beef flavoring, which may not be suitable for pets with known beef allergies. Always consult your veterinarian to explore hypoallergenic flea treatments.

Can Comfortis be crushed or split for smaller doses?

No, Comfortis tablets should not be crushed or split. Each tablet is dosed specifically for the weight range of your pet, and altering it may result in underdosing or overdosing.

Does Comfortis kill flea eggs or larvae?

Comfortis only kills adult fleas. However, by eliminating adult fleas before they reproduce, it effectively breaks the life cycle and prevents future infestations.

Will my pet need other flea treatments with Comfortis?

Comfortis provides flea-only protection. You may need to use additional treatments for ticks, mites, or intestinal parasites if advised by your vet.

Can fleas become resistant to Comfortis?

Resistance is rare but possible with long-term use of the same treatment. If you notice a decline in effectiveness, consult your vet about rotating flea control medications.

Is a prescription required to buy Comfortis?

Yes, Comfortis is an FDA-approved medication that requires a valid veterinary prescription for safe and legal dispensing.

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