Comfortis Chewable Tablets for Dogs (40.1-60 lbs) - Blue Box

Comfortis Chewable Tablets for Dogs 40.1–60 lbs (Blue Box)

Oral Flea Control with Fast Relief

Comfortis Chewable Tablets for Dogs 40.1–60 lbs (Blue Box) is a veterinary-prescribed oral flea treatment designed for medium to large dogs. It contains Spinosad, a naturally derived insecticide that targets the flea's nervous system, delivering rapid flea killing action within just 30 minutes of administration. This beef-flavored chewable tablet is easy to give and long-lasting, providing consistent, 30-day protection with every dose.

Ideal for dogs who dislike messy spot-on treatments or who swim and bathe often, Comfortis offers hassle-free flea control that stays effective rain or shine. By eliminating fleas before they lay eggs, Comfortis helps prevent flea infestations, flea allergy dermatitis, and skin irritation—protecting both your dog and your home environment.

Best For: Dogs weighing 40.1 to 60 lbs | 14 weeks of age or older
Form: Beef-flavored chewable tablet | Prescription required

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Also Available in Other Comfortis Weight Ranges

Comfortis Chewable Tablets come in multiple weight-specific options to ensure safe and effective flea protection for both dogs and cats. Select the right strength based on your pet’s weight for maximum efficacy:

• Comfortis Chewable Tablet for Dogs 5–10 lbs / Cats 4.1–6 lbs – Ideal for small dogs and petite cats.
• Comfortis Chewable Tablet for Dogs 10.1–20 lbs / Cats 6.1–12 lbs – Designed for small to mid-sized dogs and growing cats.
• Comfortis Chewable Tablet for Dogs 20.1–40 lbs / Cats 12.1–24 lbs – Suitable for medium-sized dogs and larger cats.
• Comfortis Chewable Tablet for Dogs 40.1–60 lbs – Perfect for large breed dogs needing reliable monthly flea protection. (you are viewing this product)
• Comfortis Chewable Tablet for Dogs 60.1–120 lbs – Specially formulated for extra-large dogs to ensure full-body flea defense.

Pro Tip: For best results, match the product to your pet’s exact weight range and administer monthly. Always consult your veterinarian if you're unsure which variant is right for your pet.

What Are the Benefits of Comfortis for Dogs 40.1–60 lbs?

Comfortis stands out among oral flea medications by offering:

• Fast-acting flea relief: Starts killing fleas in just 30 minutes.
• Long-lasting efficacy: 30-day continuous protection from fleas.
• Mess-free oral format: No greasy residue or risk of rub-off.
• Beef-flavored chewable: Palatable for easier administration.
• Prevents reinfestation: Breaks the flea life cycle by killing adults before they lay eggs.
• FDA-approved safety profile: Trusted by veterinarians nationwide.

💡 Did you know? Fleas begin laying eggs within 24 hours of landing on your pet. Comfortis interrupts this cycle before it begins.

Is My Dog a Good Fit for Comfortis?

Comfortis may be ideal for your dog if they:

• Dislike liquid applications or experience skin irritation from topicals
• Frequently swim or get bathed
• Live in multi-pet homes where cross-contamination is a concern
• Need fast relief due to heavy flea infestation

Not recommended if:

• Your dog is under 14 weeks old
• Your dog has a known seizure disorder (unless approved by your vet)
• Your dog has a beef protein allergy (due to flavoring)

How Do I Give Comfortis to My Dog? (Dosage and Administration)

Always consult your veterinary professional for precise dosage based on your pet’s health needs.

Administering Instructions:

• Give once per month, ideally on the same day each month.
• Must be given with food to reduce risk of vomiting and enhance absorption.
• If your dog vomits within 1 hour of dosing, give a new full dose.
• Do not split tablets; choose the correct size based on weight.

⭐ User Tips: Getting the Most Out of Comfortis

• Set a monthly reminder to avoid missed doses.
• Administer with a full meal—not just treats.
• Observe your dog for 1–2 hours post-dosing.
• Keep a calendar of flea prevention for all household pets.
• Combine with a tick preventative if needed (ask your vet).

What’s Inside Comfortis? (Active Ingredients)

Spinosad is derived from Saccharopolyspora spinosa, a soil bacterium. It’s a fast-acting neurotoxin specific to fleas that paralyzes and kills them before they can reproduce.

What Are the Potential Side Effects of Comfortis?

While most dogs tolerate Comfortis well, some may experience mild to moderate reactions.

Common Side Effects:

• Vomiting
• Diarrhea
• Lethargy or tiredness
• Temporary appetite loss
• Excessive scratching as fleas die off

Rare Side Effects:

• Seizures (especially in dogs with prior history)
• Breathing difficulty
• Severe lethargy or unresponsiveness

🚨 If any of the above severe symptoms occur, contact your veterinarian immediately.

What Precautions Should I Follow When Using Comfortis?

• Not for puppies under 14 weeks.
• Avoid use in pregnant or lactating dogs unless advised by your vet.
• Caution in dogs with a history of neurological disorders or seizures.
• Monitor your dog during the first hour after administration.
• Store at 68°F to 77°F in original packaging, away from light and moisture.

Buying & Subscription Options

• Available in 1, 2, 3, and 6-month supply packs
• Subscribe & Save to ensure timely refills and discounted pricing
• Ships directly to your door for convenience and peace of mind

What Makes Comfortis Different from Other Flea Treatments?

• Unlike topicals, Comfortis can’t be washed off after bathing or swimming.
• No mess, no isolation—your dog can interact with family and other pets immediately.
• Starts working faster than many topical flea products.

Shipping & Returns

Shipping Policy:HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.

Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.

Comfortis Flea Pill For Dogs FAQs

What is Comfortis used for?

Comfortis is an oral flea control medication that kills adult fleas and prevents flea infestations in dogs for 30 days.

Can Comfortis be used year-round?

Yes, using Comfortis monthly throughout the year helps prevent reinfestation, especially in warm climates where fleas are active year-round.

Is Comfortis safe for dogs with seizures?

Comfortis has been linked to seizures in some dogs. It should be used with caution in dogs with a seizure history under veterinary guidance.

How soon can I bathe my dog after giving Comfortis?

Since it’s oral, bathing has no impact on Comfortis. You can bathe or swim any time after dosing.

Does Comfortis protect against ticks or worms?

No, Comfortis is only for fleas. You’ll need a separate product for tick or heartworm protection.

Authoritative Resources 

• Spinosad Factsheet – NPIC (Oregon State University)
• Flea Allergy Dermatitis in Pets – VCA Animal Hospitals
• Flea Control Strategies – Merck Veterinary Manual