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Comfortis Chewable Tablet for Dogs & Cats

$19.73

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Prescription Required

Elanco SKU: CA4222Y07AM-1

Pet Weight: Dogs 5-10 lbs & Cats 4.1-6 lbs
Quantity: 1 Chewable Tablet
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Comfortis Chewable Tablets for Dogs & Cats

Product Description

Comfortis Chewable Tablets are fast-acting, vet-prescribed oral flea treatments available in multiple weight-specific strengths for dogs (5–120 lbs) and cats (4.1–24 lbs). Powered by the active ingredient spinosad, each beef-flavored chewable starts killing fleas within 30 minutes and protects your pet for a full 30 days with a single monthly dose. Comfortis is convenient for multi-pet households, as it’s safe for both dogs and cats, and avoids the mess and residue of topical solutions. Prescription required.

Ingredients

Ingredient

Purpose

Source/Note

Spinosad

Kills adult fleas

Derived from Saccharopolyspora spinosa (soil bacterium), neurotoxin specific to fleas

Beef Flavor

Enhance palatability

Artificial flavor, not suitable for beef-allergic pets

Inactive agents

Chewable tablet formation

Includes binders, starch, cellulose, flavorings, preservatives


Dosage Instruction

  • For administration to dogs and cats at least 14 weeks of age and above minimum weight listed.

  • Administer once monthly with food to maximize absorption and reduce vomiting risk.

Comparative Dosage Table

Pet Type & Weight Range

Spinosad per Tablet

Tablets to Administer

Variant Box Color / Use

Dogs 5-10 lbs / Cats 4.1-6 lbs

140 mg

1 monthly

Pink Box / Small pets

Dogs 10.1-20 lbs / Cats 6.1-12 lbs

270 mg

1 monthly

Orange Box / Small-medium

Dogs 20.1-40 lbs / Cats 12.1-24 lbs

560 mg

1 monthly

Green Box / Medium-large

Dogs 40.1-60 lbs

810 mg

1 monthly

Blue Box / Large

Dogs 60.1-120 lbs

1,620 mg*

1 monthly

Brown Box / X-Large

*Note: Double 810 mg tablets may be used for dogs over 60 lbs (confirm with your vet).

General Administration Tips

  • Administer with a full meal.

  • Do not split tablets between pets.

  • If vomiting occurs within 1 hour, repeat the full dose.

  • Always treat all pets in the home for optimal flea control.

  • Never double-dose to compensate for a missed dose.

Precautions

  • Not for use in pets under 14 weeks of age.

  • Do not use in pets with known allergies to spinosad.

  • Use caution in pets with seizure history; consult your vet.

  • Not evaluated for breeding, pregnant, or lactating females (ask your vet first).

  • Store between 68-77°F (20-25°C), away from moisture and light.

  • For animal use only; keep out of reach of children.

Storage

  • Store at 68-77°F (20-25°C).

  • Keep in original packaging, away from light and moisture.

  • Keep out of reach of children and household pets.

Benefits

  • Rapid Action: Starts killing fleas in 30 minutes, full efficacy in 4 hours.

  • Full Month Coverage: One chewable provides 30 days of protection.

  • Breaks Flea Life Cycle: Eliminates adult fleas before they lay eggs.

  • No Mess: Oral formula leaves no residue or odor.

  • Palatable: Beef flavoring is generally well accepted by pets.

  • Waterproof: Bathing and swimming do not reduce effectiveness.

  • Safe for Combined Homes: Suitable for households with both cats and dogs.

  • Reduces Flea Allergy Dermatitis (FAD): Alleviates allergic reactions caused by fleas.

  • Vet-Recommended: FDA-approved and clinically tested.

Frequently Asked Questions

What is Comfortis used for?

Comfortis is for killing and preventing adult flea infestations in dogs and cats, offering rapid relief and month-long protection.

Can Comfortis be given with heartworm preventative?

Generally yes (such as ivermectin-based products), but consult your vet before combining treatments.

Does Comfortis protect against other parasites?

No, it only targets adult fleas. Separate medication is needed for ticks, mites, or worms.

Can I give Comfortis to both my dog and cat?

Yes, but use the correct weight- and species-specific variant. Never share one tablet between pets.

What if I miss a dose?

Administer the missed dose as soon as possible, then resume the regular schedule.

Is a prescription required?

Yes, Comfortis requires a valid veterinary prescription.

Are there side effects?

Possible side effects include vomiting (most common), decreased appetite, lethargy, diarrhea, and – rarely –seizures. If your pet shows severe reactions, contact a veterinarian immediately.

Can Comfortis be used in pregnant or lactating animals?

Consult your veterinarian—safety in breeding or lactating animals has not been fully evaluated.

Does bathing affect Comfortis?

No. As an oral product, it remains effective even after bathing or swimming.