Credelio for Dogs 25.1-50 lbs

Elanco SKU: CA5454016AM


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1 Chewable Tablet (1 month supply)
2 Chewable Tablet (2 month supply)
3 Chewable Tablets (3 month supply)
6 Chewable Tablets (6 month supply)
12 Chewable Tablet (12 month supply)

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Credelio for Dogs 25.1-50 lbs

Credelio is a chewable tablet that's easy on dogs and tough on ticks and fleas. This monthly prescription kills ticks and fleas, treats flea infestations, and treats and controls tick infestations. Credelio starts working in just 4 hours and provides 100% monthly efficacy against fleas and more than 97% monthly efficacy against ticks. These tablets are approved for puppies and dogs 8 weeks of age and older who weigh 4.4-6 pounds.


Credelio kills adult fleas and is indicated for the treatment of flea infestations and the treatment and control of tick infestations for one month in dogs and puppies 8 weeks of age and older, and weighing 4.4 pounds or greater.

  • Kills fleas and ticks
  • Tasty chew
  • Easy to administer
  • Lasts a full month

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Please note product may arrive in a Hardy Paw Pharmacy vial, manufacturer packaging is shown for reference.

Dosage and Administration:

CREDELIO is given orally once a month, at the minimum dosage of 9 mg/lb (20 mg/kg).

credelio dosage schedule

CREDELIO must be administered with food.

Treatment with CREDELIO can begin at any time of the year and can continue year-round without interruption.


There are no known contraindications for the use of CREDELIO.


Not for human use. Keep this and all drugs out of the reach of children. Keep CREDELIO in a secure location out of reach of dogs, cats, and other animals to prevent accidental ingestion or overdose.


Lotilaner is a member of the isoxazoline class. This class has been associated with neurologic adverse reactions including tremors, ataxia, and seizures. Seizures have been reported in dogs receiving isoxazoline class drugs, even in dogs without a history of seizures. Use with caution in dogs with a history of seizures or neurologic disorders.

The safe use of CREDELIO in breeding, pregnant or lactating dogs has not been evaluated.

Storage Information:

Store at 15-25°C (59 -77°F), excursions permitted between 5 to 40°C (41 to 104°F).

Possible Side Effects

Because this is a new drug, monitor your dog closely while taking this medication. If you have any concerns about your animal while taking this medicine, contact your veterinarian.

Side effects that usually are not serious include:

  • Vomiting, diarrhea, decreased appetite.
  • Increased urination.

If any of these are severe, worsen, or continue to be a problem, contact your veterinarian.

Side effects that may be serious or indicate a serious problem include:

  • Vomiting that does not stop.
  • Complete loss of appetite.
  • Tremors, seizures.
  • Difficulty walking (eg, weakness, stumbling).

If you see any of these signs, contact your veterinarian immediately.

Drug & Food Interactions

No adverse reactions were observed from the concomitant use of Credelio with other medications.


Can Credelio tablets be split?
Content uniformity of whole and half tablets has not been established. Therefore, Credelio tablets are not scored and splitting of Credelio tablets is not recommended. A variety of tablet sizes have been developed to allow for accurate dosing according to a dog’s weight.

Can I combine two tablets to achieve the proper dose rate for a dog weighing more than 100 lbs?
Yes, Credelio chewable tablets are formulated to provide a minimum dose of 9 mg/lb of lotilaner. For dogs weighing greater than 100 lbs, the appropriate combination of tablets can be prescribed to achieve the desired dose for a concentration 9 mg/lb.

Does Credelio have to be given with food?
Due to reduced drug bioavailability in the fasted state, Credelio must be administered with a meal or within 30 minutes of feeding to achieve full efficacy.

How should a growing puppy be dosed?
Puppies should be weighed each month and dosed according to the dosing table based on their weight at the time of administration.

Credelio contains lotilaner, a pure enantiomer of the isoxazoline class. What does that mean?
Isoxazolines are chiral molecules with two stereoisomers that are exact mirror images of each other in a 50/50 ratio within the racemic mixture. For lotilaner, one of the enantiomers is active against parasites, the mirror image is inactive. Additional purification steps are taken during the manufacture of the lotilaner in Credelio to remove the inactive form.

Since the inactive portion has been removed, the patient does not need to metabolize the inactive enantiomer and the tablets are smaller.

What is the flavoring used in Credelio tablets?
Credelio tablets are made with meat flavoring containing pork liver and soy but no actual beef. Tablets also contain barley, wheat, and lactose.

What is the shelf life of Credelio?
Credelio has a 3-year shelf life from the date of manufacture.

Can Credelio help improve clinical signs of flea allergy dermatitis (FAD) in a dog?
Yes, Credelio can be used as part of a treatment strategy for the control of flea allergy dermatitis (FAD) due to flea infestation.

Does lotilaner kill flea eggs?
Lotilaner kills existing and newly emerged flea infestations on dogs before the female flea can lay eggs. In Credelio, lotilaner has shown a sustained speed-of-kill of greater than 99% within 8 hours and 100% within 12 hours throughout the month.

As adult fleas cannot begin laying eggs until 24 to 36 hours after taking their first blood meal, the product breaks the flea life cycle and prevents environmental flea contamination in areas to which the dog has access.

I forgot to give Credelio. What should I do?
Treatment should be administered monthly. If a dose is missed, administer Credelio with food and resume a monthly dosing schedule from that date on.

Can Credelio be administered to breeding dogs?The safe use of Credelio in breeding, pregnant or lactating dogs has not been evaluated.
Can Credelio be used in cats?While Credelio cannot be used in cats, Credelio CAT (lotilaner) is available with a lotilaner dosage rate of 2.7 mg/lb.