Vetoryl Capsules (Trilostane) for Dogs , 120mg

Once-Daily Trilostane Capsule for Cushing's Disease in Dogs

Product Description

Vetoryl Capsules (Trilostane) 120 mg is an FDA-approved, prescription-only oral treatment for Cushing's disease in dogs. Each capsule holds 120 mg of trilostane, the strongest dose in the Vetoryl range, a synthetic steroid analogue that dials back cortisol production in the adrenal cortex. One capsule a day with food manages both pituitary-dependent and adrenal-dependent forms of the disease, making it the go-to choice for larger dogs needing the highest therapeutic dose.

Benefits

• Treats Cushing's Disease: Works for both pituitary-dependent and adrenal-dependent hyperadrenocorticism, covering the two most common forms seen in dogs.
• Targets the Root Cause: Trilostane reversibly blocks 3-beta-hydroxysteroid dehydrogenase in the adrenal cortex, cutting off the source of excess cortisol production.
• Clinically Proven Results: Field studies showed most dogs experienced less thirst, less urination, and reduced panting within just 14 days of starting therapy.
• Once-Daily Convenience: One oral dose a day fits easily into any routine, making long-term disease management much more manageable for pet owners.
• Highest-Strength Option: At 120 mg per capsule, this is the strongest Vetoryl dose available, designed for large dogs that need maximum trilostane levels for effective cortisol control.
• Reversible Suppression: Trilostane's effect on cortisol production can be reversed, giving your veterinarian the flexibility to adjust or stop treatment when needed.

Ingredients

Composition Table

Other Ingredients

Gelatin capsule shell, Lactose, Magnesium Stearate, Colloidal Silicon Dioxide

How to Use

Dosage & Administration Instructions

• Prescription Required: US Federal law limits this medication to use by or on the order of a licensed veterinarian only.
• For Dogs Only: This medication is for oral use in dogs only and must never be given to humans or other animal species.
• Starting Dose: Your veterinarian will calculate the right starting dose based on your dog's weight and current condition, then prescribe accordingly.
• Give With Food: One dose each morning with food helps the body absorb it better and lowers the chance of stomach upset.
• Keep the Capsule Whole: Never open, empty, or split a capsule; always give it exactly as dispensed without any modification.
• Early Check-In: Around 10 to 14 days after starting, your vet will want to see your dog again for an ACTH stimulation test and a full biochemistry check.
• Dose Adjustments: Any changes to the dose will be guided by test results and how your dog is responding clinically; always follow your veterinarian's lead on this.
• Watch for Warning Signs: If your dog shows vomiting, diarrhea, unusual tiredness, loss of appetite, weakness, or collapse, stop the medication and call your vet straight away.
• Wash Hands After Handling: Give your hands a good wash with soap and water after every time you handle the capsules.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Hypersensitivity: Do not give to any dog that has previously shown an allergic reaction to trilostane.
• Liver or Kidney Disease: Not suitable for dogs with pre-existing liver or kidney conditions; both need to be checked before treatment begins.
• Not for Pregnant Dogs: Trilostane has been linked to birth defects and early pregnancy loss in animal studies; never use in a pregnant dog.
• Pregnant Handlers: Pregnant women or those trying to conceive should avoid handling these capsules entirely due to the risk trilostane poses to fetal development.
• Adrenal Over-Suppression: Too much adrenal suppression can develop at any dose, leading to Addison's disease; some dogs take months to recover and a few never fully do.
• Heart Medications: Use carefully alongside heart disease treatments; let your vet know about every medication your dog is currently taking before starting this one.
• Previous Mitotane Use: If your dog was previously on mitotane, at least one month must pass and ACTH levels must return to normal before switching to Vetoryl.
• Lactating and Breeding Males: Safety in nursing females and males intended for breeding has not been studied; check with your vet before use in these animals.

Possible Side Effects

• Anorexia and Vomiting: Reduced appetite and vomiting are among the most common reactions; stop treatment and reach out to your vet if either persists.
• Lethargy and Weakness: Low energy, reduced activity, and physical weakness have come up regularly in both clinical studies and real-world use.
• Diarrhea: Loose stools have been reported in some dogs; keep an eye on bowel habits and flag any changes to your veterinarian.
• Elevated Liver Enzymes: Liver enzyme rises have been noted in some dogs; regular bloodwork is the best way to catch this early.
• Electrolyte Imbalances: Shifts in potassium and sodium levels have been seen and can be a sign of adrenal over-suppression that needs prompt attention.
• Serious Adverse Events: In rare cases, severe reactions including kidney failure and Addison's disease have led to death; get your dog to a vet immediately if sudden collapse or rapid deterioration occurs.

Storage Information

• Room Temperature Storage: Keep at around 25°C (77°F), away from moisture and direct sunlight.
• Keep Away from Children and Pets: Store this prescription medication somewhere children and other animals simply cannot get to.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What condition does Vetoryl (Trilostane) 120 mg treat in dogs?

Ans: Vetoryl 120 mg treats hyperadrenocorticism, better known as Cushing's disease, in dogs. It works for both the pituitary-dependent form, which is the most common, and the adrenal-dependent form, where a tumor on the adrenal gland drives excess cortisol production throughout the body.

Q2: How does the 120 mg capsule differ from the 60 mg capsule?

Ans: The 120 mg capsule is the strongest in the Vetoryl range, delivering double the dose of the 60 mg capsule per administration. It is designed for larger dogs where a lower strength would fall short of the therapeutic target. Your veterinarian will determine which strength matches your dog's weight and clinical needs.

Q3: How quickly does Vetoryl 120 mg start working in dogs?

Ans: Most dogs showed noticeable improvement within 14 days of starting treatment in clinical field studies. Early signs of progress included less thirst, reduced urination, and lower panting levels. A follow-up ACTH stimulation test is usually scheduled around the 10 to 14 day mark to check how well the dose is working.

Q4: Why does my large dog need regular testing while on Vetoryl 120 mg?

Ans: Testing is essential because even at the right dose, Vetoryl can push adrenal suppression too far, causing Addison's disease. Regular ACTH stimulation tests and biochemistry panels keep cortisol levels within the safe target range and give your vet the information needed to fine-tune the dose over time.

Q5: Is Vetoryl (Trilostane) 120 mg a cure for Cushing's disease in large dogs?

Ans: No. Vetoryl manages the condition rather than curing it. It reduces cortisol production and relieves symptoms, but the underlying disease remains. Stopping the medication allows cortisol levels to climb again and symptoms to return, which is why most dogs stay on it for life.

Clinical Research

FDA - Vetoryl Drug Approval

Merck Veterinary Manual – Cushing's Syndrome in Dogs

PetMD – Trilostane for Dogs