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$19.99 | $24.99
Product title
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$19.99 | $24.99
Product title
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$19.99 | $24.99
Product title
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$19.99 | $24.99
Once-Daily Trilostane Capsule for Cushing's Disease in Dogs
Product Description
Vetoryl Capsules (Trilostane) 5 mg is an FDA-approved, prescription-only oral treatment for Cushing's disease in dogs. Each capsule holds 5 mg of trilostane, a synthetic steroid analogue that brings cortisol production in the adrenal cortex under control. Given once daily with food, it manages both pituitary-dependent and adrenal-dependent forms of the condition and is the smallest strength in the range, making it the natural starting point for toy breeds and very small dogs.
Benefits
- Treats Cushing's Disease: Effective for both pituitary-dependent and adrenal-dependent hyperadrenocorticism, the two most frequently diagnosed forms of Cushing's disease in dogs.
- Targets the Root Cause: By reversibly blocking 3-beta-hydroxysteroid dehydrogenase in the adrenal cortex, trilostane reduces the overproduction of cortisol right at its source.
- Clinically Proven Results: Most dogs in clinical field studies showed measurable improvement in thirst, urination, and panting within the first 14 days of therapy.
- Once-Daily Convenience: One oral dose each day is all that is needed, making it simple to build into a long-term daily care routine.
- Ideal Starter Strength: As the smallest available Vetoryl dose, the 5 mg capsule is the go-to choice for toy breeds and very small dogs beginning trilostane therapy for the first time.
- Reversible Suppression: Trilostane's cortisol-reducing effect can be reversed, so your veterinarian can safely adjust or stop treatment as your dog's needs change over time.
Ingredients
Composition Table
| Ingredient | Quantity |
| Trilostane | 5 mg per capsule |
Other Ingredients
Gelatin capsule shell, Lactose, Magnesium Stearate, Colloidal Silicon Dioxide
How to Use
Dosage & Administration Instructions
- Prescription Required: US Federal law limits this medication to use by or on the order of a licensed veterinarian only.
- For Dogs Only: This medication is for oral use in dogs only and must never be given to humans or other animal species.
- Starting Dose: Your veterinarian will work out the appropriate starting dose for your dog based on body weight and individual health needs before prescribing.
- Give With Food: Give one dose each morning with food to support proper absorption and reduce the likelihood of digestive upset.
- Keep the Capsule Whole: Never break open, empty, or divide the capsule; it should always be given intact as your vet or pharmacist dispensed it.
- Early Check-In: Plan for a vet visit around 10 to 14 days after starting, where an ACTH stimulation test and full biochemistry panel will be carried out.
- Dose Adjustments: Changes to the dose are made based on test results and how your dog is doing clinically; never adjust the dose without your veterinarian's direction.
- Watch for Warning Signs: If your dog vomits, has diarrhea, seems unusually tired, loses interest in food, becomes weak, or collapses, stop the medication right away and call your vet.
- Wash Hands After Handling: Wash your hands thoroughly with soap and water each time you handle the capsules.
Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.
Additional Information
Precautions
- Hypersensitivity: Do not use in dogs with a known allergic reaction or sensitivity to trilostane.
- Liver or Kidney Disease: Dogs with liver or kidney problems are not suitable candidates; both organ systems should be evaluated before treatment starts.
- Not for Pregnant Dogs: Trilostane has been associated with birth defects and early pregnancy loss in animal studies; it must never be used in pregnant dogs.
- Pregnant Handlers: Anyone who is pregnant or trying to conceive should avoid all contact with these capsules given the known teratogenic risk of trilostane.
- Adrenal Over-Suppression: Addison's disease can develop regardless of the dose used; some dogs need months to recover normal adrenal function and some may not recover fully at all.
- Heart Medications: Take extra care if your dog is on any heart medication; inform your vet of everything your dog is currently taking before beginning treatment.
- Previous Mitotane Use: At least one full month must pass after stopping mitotane, and ACTH levels must be back to normal, before Vetoryl therapy can begin.
- Lactating and Breeding Males: The safety profile in nursing females and males used for breeding has not been established; always check with your vet before using in these animals.
Possible Side Effects
- Anorexia and Vomiting: A drop in appetite and vomiting are the most commonly reported reactions; if your dog experiences either, pause the medication and get in touch with your vet.
- Lethargy and Weakness: Tiredness, reduced interest in activity, and general physical weakness have been consistently reported across clinical and post-market data.
- Diarrhea: Loose or watery stools have been noted in some dogs; keep an eye on bowel habits and report anything unusual to your veterinarian.
- Elevated Liver Enzymes: Some dogs show rises in liver enzyme levels; this is another reason why regular bloodwork matters throughout treatment.
- Electrolyte Imbalances: Changes in potassium and sodium balance can signal that adrenal suppression has gone too far and needs to be addressed quickly.
- Serious Adverse Events: Rare but serious outcomes including kidney failure and Addison's disease have in some cases been fatal; get veterinary help immediately if your dog suddenly worsens or collapses.
Storage Information
- Room Temperature Storage: Keep at around 25°C (77°F), away from moisture and direct sunlight.
- Keep Away from Children and Pets: Store this prescription medication somewhere children and other animals simply cannot get to.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What condition does Vetoryl (Trilostane) 5 mg treat in dogs?
Ans: Vetoryl 5 mg treats hyperadrenocorticism, more commonly known as Cushing's disease, in dogs. It is effective for both the pituitary-dependent type, which is the most frequently seen form, and the adrenal-dependent type, where excess cortisol stems from a growth on the adrenal gland.
Q2: How does trilostane in Vetoryl work to control Cushing's disease?
Ans: Trilostane reversibly blocks 3-beta-hydroxysteroid dehydrogenase, the enzyme that drives cortisol production in the adrenal cortex. By interrupting this step, it reduces the amount of cortisol the body produces, easing the hormonal overload that causes the symptoms of Cushing's disease in dogs.
Q3: How quickly does Vetoryl 5 mg start working in dogs?
Ans: Most dogs in clinical studies showed clear signs of improvement within 14 days of starting Vetoryl. Owners typically noticed less thirst, fewer bathroom trips, and reduced panting fairly early on. A follow-up ACTH stimulation test is usually booked for the 10 to 14 day mark to check how the dose is performing.
Q4: Why does my dog need regular testing while on Vetoryl 5 mg?
Ans: Regular testing matters because even a low dose can sometimes suppress adrenal function more than intended, leading to Addison's disease. Routine ACTH stimulation tests and biochemistry panels keep cortisol within a safe range and help your vet catch any concerning shifts before they become serious.
Q5: Is Vetoryl (Trilostane) 5 mg a cure for Cushing's disease in dogs?
Ans: No. Vetoryl controls the condition by lowering cortisol production but does not remove the underlying cause. When treatment stops, cortisol levels rise again and symptoms return, which is why the vast majority of dogs with Cushing's disease remain on this medication for life.