Vetoryl Capsules (Trilostane) for Dogs - 20mg

Once-Daily Trilostane Capsule for Cushing's Disease in Dogs

Product Description

Vetoryl Capsules (Trilostane) 20 mg is an FDA-approved, prescription-only oral medication for managing Cushing's disease in dogs. Each capsule delivers 20 mg of trilostane, a synthetic steroid analogue that reversibly inhibits cortisol production in the adrenal cortex. Given once daily with food, it effectively manages both pituitary-dependent and adrenal-dependent forms of the disease, offering a precise intermediate dose option for small to medium-sized dogs.

Benefits

• Treats Cushing's Disease: Indicated for both pituitary-dependent and adrenal-dependent hyperadrenocorticism, the two most common forms in dogs.
• Addresses Root Cause: Trilostane blocks excessive cortisol by reversibly inhibiting 3-beta-hydroxysteroid dehydrogenase within the adrenal cortex of dogs.
• Clinically Proven Results: Field studies showed improvement in signs like reduced thirst, urination, and panting in most dogs.
• Once-Daily Convenience: Given orally once a day, making it straightforward to include in a dog's long-term daily routine.
• Precise Intermediate Dose: The 20 mg capsule bridges the gap between 10 mg and 30 mg strengths for more accurate dosing.
• Reversible Suppression: Trilostane's cortisol inhibition is reversible, allowing therapy to be safely adjusted or stopped under veterinary guidance.

Ingredients

Composition Table

Other Ingredients

Gelatin capsule shell, Lactose, Magnesium Stearate, Colloidal Silicon Dioxide

How to Use

Dosage & Administration Instructions

• Prescription Required: US law requires this drug to be given only when prescribed or directed by a licensed veterinarian.
• For Dogs Only: Intended for oral use in dogs only and must not be given to humans or other animal species.
• Give With Food: Administer orally once daily, preferably in the morning with food to improve absorption and reduce stomach upset.
• Do Not Divide Capsules: Never empty the capsule contents or split it; always administer the whole capsule as dispensed.
• Monitor After Starting: Around 10 to 14 days in, a re-examination, ACTH stimulation test, and serum biochemical panel should be conducted.
• Dose Adjustments: Any changes to the dose should be based on ACTH stimulation results and made under your veterinarian's guidance.
• Stop If Side Effects Occur: Stop therapy immediately and contact your veterinarian if vomiting, diarrhea, lethargy, appetite loss, or collapse occurs.
• Wash Hands After Handling: Always wash hands thoroughly with soap and water after handling the capsules each time.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Hypersensitivity Contraindication: Do not use in dogs that have previously shown an allergic reaction or hypersensitivity to trilostane.
• Liver or Kidney Disease: Dogs with hepatic disease or poor kidney function should not receive Vetoryl, and organ tests should be done first.
• Not for Pregnant Dogs: Trilostane has caused teratogenic effects and early pregnancy loss in lab animals; never use in pregnant dogs.
• Pregnant Handlers: Women who are pregnant or trying to conceive must never handle Vetoryl capsules due to teratogenic risks.
• Adrenal Over-Suppression Risk: Addison's disease can develop at any dose and some dogs may never fully regain normal adrenal function.
• Caution With Heart Medications: Use with caution in dogs on heart disease medications; inform your veterinarian of all current medications beforehand.
• Prior Mitotane Treatment: Wait at least one month after stopping mitotane and until ACTH levels normalize before starting Vetoryl therapy.
• Lactating and Breeding Males: The safety of Vetoryl has not been evaluated in lactating dogs or males intended for breeding.

Possible Side Effects

• Anorexia and Vomiting: Loss of appetite and vomiting are among the most commonly reported side effects; contact your vet immediately.
• Lethargy and Weakness: Depression, reduced activity, and physical weakness have been frequently reported in both field studies and post-approval experience.
• Diarrhea: Loose stools or diarrhea have been reported; monitor your dog's bowel movements and report any changes promptly.
• Elevated Liver Enzymes: Elevated hepatic enzyme levels have been reported; routine biochemical monitoring helps detect these changes at an early stage.
• Electrolyte Imbalances: Elevated potassium and decreased sodium levels have been reported and may signal adrenal over-suppression in treated dogs.
• Serious Adverse Events: Death has been reported in some cases; contact your veterinarian immediately if sudden collapse or rapid deterioration occurs.

Storage Information

• Room Temperature Storage: Store at room temperature 25°C (77°F), with excursions permitted between 15°C and 30°C (59°F to 86°F).
• Keep Away from Children and Pets: Store this prescription medication securely out of reach of children and other animals at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What condition does Vetoryl (Trilostane) 20 mg treat in dogs?

Ans: Vetoryl Capsules treat hyperadrenocorticism, commonly known as Cushing's disease, in dogs. It works for both pituitary-dependent and adrenal-dependent forms of the disease, where excess cortisol is produced by either a pituitary or adrenal gland tumor, causing various clinical signs.

Q2: How is the 20 mg capsule different from other Vetoryl strengths?

Ans: The 20 mg trilostane capsule provides an intermediate option between the 10 mg and 30 mg strengths. It allows veterinarians to prescribe a more accurate weight-based dose for dogs whose ideal dose falls between those two strengths, avoiding unnecessary over or under-dosing.

Q3: How quickly does Vetoryl 20 mg start working in dogs?

Ans: Clinical field studies showed improvement in most dogs within 14 days of starting Vetoryl. Early signs include reduced thirst, less urination, decreased panting, and better appetite. A follow-up ACTH stimulation test is conducted after the first 10 to 14 days.

Q4: Why does my dog need regular testing while on Vetoryl?

Ans: Regular ACTH stimulation tests and biochemical panels are required because Vetoryl can cause adrenal over-suppression at any dose, leading to Addison's disease. Monitoring keeps cortisol within a safe range and allows your veterinarian to adjust the dose appropriately and safely over time.

Q5: Is the Cushing's disease trilostane capsule a permanent cure for dogs?

Ans: No. Vetoryl controls the signs of Cushing's disease by suppressing excess cortisol but does not cure the underlying condition. If the medication is stopped or missed regularly, cortisol levels will rise again and signs will return, making lifelong therapy typically necessary for dogs.

Clinical Research

FDA - Vetoryl Drug Approval

Merck Veterinary Manual – Cushing's Syndrome in Dogs

PetMD – Trilostane for Dogs