Proven adult heartworm treatment for Class 1-3 dogs

Product Description

Immiticide Injection - Heartworm Treatment for Dogs 50mg, 2mL (5 vials) delivers melarsomine dihydrochloride, the only FDA-approved adulticide for stabilized Class 1-3 canine heartworm disease. This prescription treatment kills immature and adult heartworms in the pulmonary arteries and heart, helping reduce clinical signs, limit further organ damage, and support safer long-term recovery under strict veterinary supervision.

Benefits

• Targeted Adulticide Action: Kills immature and mature adult Dirofilaria immitis heartworms in infected dogs.
• Class 1-3 Indication: Labeled for stabilized Class 1, 2, and 3 heartworm disease cases.
• Evidence-Backed Efficacy: Clinical trials show high worm-reduction and antigen-conversion rates after treatment.
• Veterinarian-Administered Protocol: Deep intramuscular dosing performed only by licensed veterinarians for safety.
• Convenient Multi-Vial Pack: Five 50 mg vials support complete treatment courses for appropriately sized dogs.

Ingredients

Active Ingredient: Melarsomine Dihydrochloride 50 mg.
Inactive Ingredients: Sodium Citrate, Glycine, and Water for Injection.

How to Use

Dosage & Administration Instructions

• Deep IM Injection Only: Administer by deep intramuscular injection in the lumbar (epaxial) muscles L3-L5. Do not inject intravenously or in any other muscle group.
• Standard Dose Rate: Dose at 2.5 mg/kg (0.1 mL/kg) per injection, accurately calculated from the dog’s weight using the dosing table.
• Class 1-2 Regimen: Give 2.5 mg/kg intramuscularly twice, 24 hours apart; a second two-dose series may be considered four months later based on response and condition.
• Class 3 Alternate Regimen: Stabilize first, then give one 2.5 mg/kg injection; about one month later, administer 2.5 mg/kg twice, 24 hours apart.
• Reconstitution and Use: Reconstitute each 50 mg vial only with the supplied 2 mL sterile diluent; use immediately or within 24 hours if refrigerated and protected from light.

Additional Information

Precautions

• Disease Class Limitation: Contraindicated in dogs with very severe (Class 4) heartworm disease and caval syndrome.
• Low Safety Margin: Immiticide has a low margin of safety; overdosing or incorrect administration can cause severe toxicity.
• Route and Site Restrictions: Must be given only as deep intramuscular injections in lumbar epaxial muscles; avoid superficial injection or leakage.
• Thromboembolism Risk: All treated dogs’ risk post-treatment pulmonary thromboembolism; strict exercise restriction and close monitoring are essential after injections.
• Use in Breeding Dogs: Safety has not been determined in breeding animals or pregnant or lactating bitches; use only if benefits outweigh risks in veterinary judgment.

Shipping & Returns

We offer ground, express, priority, and international delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is Immiticide Injection - Heartworm Treatment for Dogs 50mg, 2mL (5 vials) used for?

Ans: Immiticide Injection is a prescription treatment used to eliminate immature and adult heartworms in dogs diagnosed with stabilized Class 1, 2, or 3 heartworm disease. It is the only FDA-approved melarsomine adulticide, administered exclusively by veterinarians via deep intramuscular injection.

Q2: How does this heartworm treatment work inside the dog’s body?

Ans: The medication contains melarsomine dihydrochloride, an organic arsenical compound that targets adult Dirofilaria immitis worms lodged in the heart and pulmonary arteries. As worms die, the body gradually clears them, which helps reduce disease progression but requires strict rest to limit complications.

Q3: Which dogs are candidates for treatment with this injectable heartworm medication?

Ans: This product is indicated for dogs with confirmed Class 1, 2, or stabilized Class 3 heartworm disease. Veterinarians perform staging using clinical signs, imaging, and lab work, then determine whether the dog is stable enough to undergo adulticide therapy and which dosing protocol is safest.

Q4: How many injections are typically required for a complete treatment course?

Ans: Most dogs receive either a two-dose series or a three-dose alternate regimen. For many Class 1 and 2 dogs, two injections are administered 24 hours apart, sometimes followed by another two-dose series months later. Stabilized Class 3 dogs usually receive the three-dose protocol.

Q5: Why is strict exercise restriction so necessary after adult heartworm treatment?

Ans: When heartworms die, fragments can lodge in pulmonary vessels, causing thromboembolism. Limiting activity reduces strain on the heart and lungs during this fragile period. Veterinarians typically recommend cage rest or minimal movement for several weeks after injections to enhance safety and improve outcomes.

Q6: What common side effects might occur following injections with this medication?

Ans: Dogs frequently experience localized injection-site reactions, such as pain, swelling, tenderness, or stiffness, along with systemic signs, including coughing, lethargy, reduced appetite, fever, or abnormal lung sounds. Most reactions resolve with time and supportive care, though rare severe events can occur.

Q7: Can dogs with very advanced heartworm disease receive this injectable treatment?

Ans: Immiticide is contraindicated in dogs with very severe Class 4 heartworm disease, especially those with caval syndrome. These patients typically require alternate interventions such as surgical worm extraction and intensive supportive care instead of standard melarsomine adulticide treatment protocols.

Q8: Who is allowed to mix and inject this heartworm medication?

Ans: Only licensed veterinarians, or trained staff under direct veterinary supervision, should reconstitute the sterile powder and administer deep lumbar intramuscular injections. Accurate dosing, careful handling, and immediate access to medical support are essential because of the medication’s low safety margin and potential adverse reactions.

Q9: How is the correct dose determined for each dog?

Ans: The veterinarian weighs the dog precisely, then calculates the total dose using 2.5 mg/kg, equivalent to 0.1 mL/kg of reconstituted solution. A dosing table helps verify that the chosen volume matches the dog’s body weight before each injection is administered.

Q10: How should the vials be stored and handled before and after reconstitution?

Ans: Unreconstituted vials are stored upright at controlled room temperature. Immediately before use, the powder is aseptically reconstituted with the supplied sterile water. The solution should be used promptly, within 24 hours if refrigerated and protected from light, and then discarded.