Lisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets

Lisinopril and Hydrochlorothiazide Tablets for Pet Blood Pressure

Product Description

Lisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets are a prescription-only, higher-strength dual-action combination used off-label in dogs and cats when lower-dose antihypertensive therapy has not brought blood pressure under adequate control. Lisinopril cuts angiotensin II levels by blocking ACE to relax vessel walls, while hydrochlorothiazide lowers circulatory fluid by pushing excess sodium and water out through the kidneys.

Benefits

• Higher Strength Option: A stronger option for pets whose high blood pressure has not been adequately controlled by lower-strength antihypertensive combinations.
• ACE Inhibition Action: Lisinopril blocks the angiotensin-converting enzyme, cutting angiotensin II levels and letting arteries relax and widen in treated pets.
• Diuretic Pressure Reduction: Hydrochlorothiazide lowers circulatory fluid volume by driving excess sodium and water out through the kidneys in treated pets.
• Advanced Hypertension Control: A more powerful approach for pets whose persistent hypertension has not responded to lower-strength antihypertensive combinations under vet care.
• Proteinuria Management: Helps reduce abnormal protein leakage into urine associated with glomerular disease and chronic kidney disease in dogs and cats.

Ingredients

Active Ingredients

How to Use

Dosage & Administration Instructions

Lisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets are a prescription-only medication. A valid veterinarian prescription is required to purchase this product. Please follow your veterinarian's instructions carefully for the dosage and administration of this medication.

Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.

Placing a tablet inside a soft Pill Pocket or wrapping it in a small piece of your pet's favorite treat is a simple and caring way to make each dose easier for both of you. A pill pocket treat takes the stress out of medicating your pet and helps ensure no dose is missed. Shop Pill Pockets for Dogs | Shop Pill Pockets for Cats

Additional Information

Precautions

• ACE Inhibitor Allergy: Avoid in pets with a known allergy to lisinopril, enalapril, benazepril, or any other ACE inhibitor medication.
• Hyperkalemia Risk: This combination may raise blood potassium levels; avoid potassium supplements alongside this product without direct veterinary guidance.
• Severe Kidney Disease: Both components can further reduce kidney perfusion; use with extra caution in pets with significant renal impairment.
• Low Blood Volume: Both components push pressure down; avoid in dehydrated pets or those with low blood volume for this reason.
• Pregnancy Caution: Both lisinopril and hydrochlorothiazide may harm fetuses and nursing young; do not use in pregnant or nursing animals.
• Lupus or Autoimmune History: Flag any history of lupus, blood disorders, or autoimmune conditions to your vet before this product is introduced.
• Sulfonamide Allergy: Avoid in pets allergic to sulfonamide drugs, as hydrochlorothiazide is chemically related to the sulfonamide medication class.
• Drug Interactions: NSAIDs, ARBs, potassium-sparing diuretics, lithium, and cholestyramine all interact with this combination; always keep your vet fully informed.
• Regular Monitoring Required: Blood pressure, kidney values, and electrolytes need checking before starting and regularly throughout the full course of treatment.
• Prescription Only: No veterinary FDA approval exists for either ingredient; both require a licensed veterinarian's direct order before dispensing.

Possible Side Effects

• Low Blood Pressure: Weakness, lethargy, or difficulty standing may signal hypotension; contact your vet promptly if any of these signs develop.
• Kidney Dysfunction: Rising kidney values or shifts in thirst and urination may indicate renal stress from lisinopril in treated pets.
• Electrolyte Imbalances: Hypokalemia, hyponatremia, or hypomagnesemia may develop; watch for muscle weakness, tremors, or irregular heartbeat in treated pets.
• Vomiting and Diarrhea: Gastrointestinal reactions including vomiting and loose stools are among the more frequently reported side effects in treated pets.
• Dry Cough: A persistent dry cough may develop in some pets on lisinopril; contact your vet if this sign appears.
• Allergic Reactions: Facial swelling, hives, or breathing trouble require stopping this product at once and getting emergency veterinary attention without delay.

Storage Information

• Room Temperature Storage: Keep sealed at room temperature away from direct light, heat, and moisture to preserve both active ingredients over time.
• Avoid Humidity Exposure: Always keep the container firmly closed between uses to prevent humidity from degrading tablet quality throughout the shelf life.
• Keep Out of Reach: Keep this product away from children and other animals; accidental ingestion of either ingredient carries serious health risks.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What is the Lisinopril 20 mg and Hydrochlorothiazide 25 mg combination used for in pets?

Ans: Used off-label in dogs and cats to manage systemic hypertension not brought under control by lower-strength therapy. Lisinopril relaxes vessel walls by blocking ACE while hydrochlorothiazide reduces fluid volume through renal excretion, addressing two distinct mechanisms behind high blood pressure.

Q2: Can this combination cause my pet's kidneys to stop working properly?

Ans: Yes. Both components can affect kidney function, particularly if blood pressure drops too low or the pet becomes dehydrated. Regular blood tests throughout treatment allow your vet to catch any signs of renal stress before they become a serious problem.

Q3: Why does this combination also help with kidney disease in pets?

Ans: Lisinopril reduces intraglomerular pressure by blocking angiotensin II, helping limit the protein leakage into urine seen with glomerular and chronic kidney disease. This kidney-protective effect is why vets may choose an ACE inhibitor over other antihypertensive options for affected pets.

Q4: What electrolyte side effects should I watch for in my pet on this combination?

Ans: Hydrochlorothiazide can lower potassium, sodium, and magnesium levels in treated pets. Watch for muscle weakness, lethargy, tremors, or an irregular heartbeat as warning signs. Regular blood tests throughout treatment help your vet catch and address any electrolyte imbalances early.

Q5: Do I need a prescription for Lisinopril 20 mg and Hydrochlorothiazide 25 mg Tablets for my pet?

Ans: Yes, this is a prescription-only combination. Neither ingredient carries veterinary FDA approval, and both can only be dispensed on a licensed veterinarian's direct order. Regular monitoring appointments throughout treatment are essential for keeping your pet safe on this product.