Lutalyse HighCon Injection – Estrus Control for Cattle

Lutalyse HighCon Injection is the prostaglandin concentrate solution used in reproductive management for cattle. Its preparation consists of dinoprost tromethamine and can be used in estrus synchrony, induction of luteolysis, and for the support of breeding programs in beef and dairy cows. Therefore, injectable solutions regulate the estrous cycle, treat uterine infections, and induce abortions whenever necessary, all things the injectable product does to enhance reproductive efficiencies. As compared to standard Lutalyse, Lutalyse HighCon offers lower volumes for injections because of its highly concentrated strength, allowing for better ease of use and convenience.

Benefits:

• Estrus Synchronization: Synchronization of breeding programs will greatly enhance reproductive efficiency.
• High Concentration: Lower volume for injection than regular Lutalyse.
• Luteolysis and Termination of Pregnancy: Effectively induces lucal regression when necessary.
• Treating of Uterine Infection: Aid in getting rid of postpartum reproductive tract infections.
• Veterinary-Reliable Reproductive Support – A reliable solution for cattle breeding management.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

How is Lutalyse HighCon administered?

Lutalyse HighCon is administered by intramuscular (IM) injection. The lower injection volume improves convenience without loss of effectiveness. Always follow veterinary recommendations for maximum dosage.

What is the difference between Lutalyse HighCon and regular Lutalyse?

Lutalyse HighCon has a higher concentration of dinoprost tromethamine, enabling a lower injection volume to have the same effectiveness as regular Lutalyse.

Dosage & Administration:

As with any multi-dose vial, practice aseptic techniques in withdrawing each dose to decrease the possibility of post-injection bacterial infections. Adequately clean and disinfect the vial stopper before entry with a sterile needle and syringe. Use only sterile needles, and use each needle only once. No vial stopper should be entered more than 20 times.

1. For Estrus Synchronization in Beef Cows, Beef Heifers and Replacement Dairy Heifers. LUTALYSE HighCon Injection is used to control the timing of estrus and ovulation in estrous cycling cattle that have a corpus luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) intramuscularly or subcutaneously either once or twice at a 10 to 12-day interval. With the single injection, cattle should be bred at the usual time relative to estrus. With the two injections, cattle can be bred after the second injection either at the usual time relative to detected estrus or at about 80 hours after the second injection of LUTALYSE HighCon Injection. Estrus is expected to occur 1 to 5 days after injection if a corpus luteum is present. Cattle that do not become pregnant to breed at estrus on days 1 to 5 after injection will be expected to return to estrus in about 18 to 24 days.
2. For Unobserved (Silent) Estrus in Lactating Dairy Cows with a Corpus Luteum. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection. Breed cows as they are detected in estrus. If estrus has not been observed by 80 hours after injection, breed at 80 hours. If the cow returns to estrus, breed at the usual time relative to estrus.
3. For Treatment of Pyometra (chronic endometritis) in Cattle. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection.
4. For Abortion of Beef Cows, Beef Heifers & Replacement Dairy Heifers. LUTALYSE HighCon Injection is indicated for its abortifacient effect in beef cows, beef heifers, and replacement dairy heifers during the first 100 days of gestation. Inject a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection. Cattle that abort will abort within 35 days of injection.
5. For use with FACTREL (gonadorelin injection) Injection to synchronize estrous cycles to allow fixed-time artificial insemination (FTAI) in lactating dairy cows: Administer 2 to 4 mL FACTREL Injection (100-200 mcg gonadorelin) per cow as an intramuscular injection in a treatment regimen with the following framework:
• Administer the first dose of FACTREL Injection (2-4 mL) on Day 0
• Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection 6-8 days after the first dose of FACTREL Injection.
• Administer a second dose of FACTREL Injection (2-4 mL) 30 to 72 hours after the LUTALYSE HighCon Injection.
• Perform FTAI 0 to 24 hours after the second dose of FACTREL Injection, or inseminate cows on detected estrus using standard herd practices.
6. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for Synchronization of Estrus in Lactating Dairy Cows:
• Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday).
• Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection at the time of removal of the EAZI-BREED CIDR Cattle Insert.
• Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following normal herd practices.
7. For use with EAZI-BREED CIDR (progesterone intravaginal insert) Cattle Insert for synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers:
• Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday).
• Administer a dose of 2 mL LUTALYSE HighCon Injection (25 mg dinoprost) by intramuscular or subcutaneous injection 1 day before EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7-day administration period.
• Observe animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals about 12 hours after onset of estrus.

Warnings:

User Safety: Not for human use. Keep out of the reach of children. Women of childbearing age, asthmatics, and persons with bronchial and other respiratory problems should exercise extreme caution when handling this product. In the early stages, women may be unaware of their pregnancies. Dinoprost tromethamine is readily absorbed through the skin and can cause abortion and/or bronchospasms. Accidental spillage on the skin should be washed off immediately with soap and water.

Residue Warnings: No milk discard or preslaughter drug withdrawal period is required for labeled uses in cattle. Use of this product over the approved dose may result in drug residues.

Animal Safety Warnings: Severe localized clostridial infections associated with injection of LUTALYSE Injection have been reported. In rare instances, such infections have resulted in death. Aggressive antibiotic therapy should be employed at the first sign of infection at the injection site whether localized or diffuse. Do not administer intravenously (IV) as this route may potentiate adverse reactions. Non-steroidal anti-inflammatory drugs may inhibit prostaglandin synthesis; therefore this class of drugs should not be administered concurrently. Do not administer to pregnant cattle, unless abortion is desired. Cattle administered a progestin would be expected to have a reduced response to LUTALYSE Injection.

Storage:

Store below 25°C (77°F), with brief excursions between 0°C and 40°C (32°F and 104°F). Use contents within 12 weeks of the first vial puncture. The stopper may be punctured a maximum of 20 times.

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FAQ

What is Lutalyse HighCon Injection used for?

Lutalyse HighCon is an injection of prostaglandin to be used in estrus synchronization, pregnancy termination, and treatment of uterine infections (pyometra) in beef and dairy cows.

What is the correct dosage of Lutalyse HighCon?

The usual dose is 2mL (25mg dinoprost) per cow, but a veterinarian should be consulted for accurate dosing according to your herd's reproductive management plan.

Is a prescription needed to buy Lutalyse HighCon?

Yes, Lutalyse HighCon is a prescription drug, and a veterinarian has to approve its use.

How soon after injection does estrus begin?

Estrus (heat) typically follows 2 to 5 days post-injection, depending on the timing of injection in the estrous cycle.

Can pregnant cows be treated with Lutalyse HighCon?

Yes, but will induce an abortion if given at the appropriate stage, thus should only be used on veterinary recommendation.

Are there side effects to the use of Lutalyse HighCon?

A few cows can show temporary discomfort in the injection site, elevated body temperature, or sweating. Have a veterinarian consult if reactions are severe.