Midamox Topical Solution for Cats, 5.1-9 lbs, Orange Box

Flea, Heartworm, and Worm Spot-On for Small to Medium Cats

Product Description

Midamox Topical Solution for Cats 5.1–9 lbs is an FDA-approved prescription spot-on treatment applied once a month to cats and kittens nine weeks and older within this weight range. Each orange-box applicator delivers imidacloprid and moxidectin, tackling heartworm disease, flea infestations, ear mites, roundworms, and hookworms in a single application. Uniquely, this applicator size also holds FDA approval for heartworm prevention and flea treatment in ferrets weighing at least 2 lbs. It is bioequivalent to Advantage Multi for Cats.

Benefits

• Heartworm Disease Prevention: Keeps small to medium cats protected from Dirofilaria immitis heartworm infection when applied on a consistent monthly schedule.
• Kills Fleas and Controls Infestations: Targets adult fleas on the cat and helps bring active flea infestations in the surrounding home environment under control.
• Clears Ear Mite Infestations: Each monthly application treats and controls Otodectes cynotis ear mite infestations, keeping cats comfortable and itch-free.
• Eliminates Intestinal Worms: Gets rid of Toxocara cati roundworms and Ancylostoma tubaeforme hookworms in cats falling within this weight bracket.
• Approved for Ferrets Too: This is the only Midamox for Cats applicator size with FDA approval for heartworm prevention and flea treatment in ferrets at least 2 lbs in weight.
• Proven Bioequivalent Formula: Norbrook-manufactured and FDA-confirmed to match Advantage Multi for Cats in active ingredient concentration and clinical performance.

Ingredients

Active Ingredients

Imidacloprid 40mg, Moxidectin 4mg per applicator

How to Use

Midamox Topical Solution for Cats 5.1–9 lbs is a prescription-only medication. A valid prescription from a licensed veterinarian is required to purchase this medicine.

Please follow your veterinarian's specific instructions for dosage, frequency, and administration of this medication for your cat.

Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.

Additional Information

Precautions

• Head Base Application Only: The solution should go at the back of the cat's head, not between the shoulder blades, to stop the cat from reaching the spot while grooming.
• Stop Licking Post-Application: Keep the cat away from the treated area for at least 30 minutes and separate pets in shared households until the spot is fully dry.
• Dog Formula is Dangerous for Cats: Moxidectin levels in the dog version of this product far exceed what cats can tolerate and can prove fatal if applied to them.
• Skip Application on Unwell Cats: Cats that are sick, underweight, or in poor condition should not receive this product until cleared by a veterinarian.
• Healthy Skin Only: The application site must be free of broken, inflamed, or irritated skin before the product is applied each month.
• Age and Weight Minimum: Cats and kittens must be at least nine weeks old, and ferrets must weigh a minimum of 2 lbs, before this product can be used.

Possible Side Effects

• Excessive Drooling: Hypersalivation is the side effect seen most often and tends to happen when a cat manages to groom and swallow some of the solution.
• Skin Reactions at Application Site: Patchy hair loss, redness, minor skin lesions, or itching may appear at the treated spot but typically clear up without treatment.
• Temporary Hair Changes: The fur at the application site may look stiff or greasy for a short time after each application; this is normal and not a cause for concern.
• Stomach Upset: Some cats experience vomiting or a dip in appetite after monthly application; these effects are usually mild and short-lived.
• Neurological Warning Signs: Trembling, unsteady walking, hiding, or unusual hyperactivity are uncommon but require emergency veterinary care without hesitation.

Storage Information

• Room Temperature Storage: Tuck applicators away from heat and direct light in a consistently cool spot to keep them in good condition until use.
• Leave in Sealed Pouch: Each applicator should stay inside its foil pouch right up until the moment of application to shield it from heat and light exposure.
• Secure Storage Essential: Put them somewhere completely out of reach of children and any animals in the home that are not being treated with this product.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What does the orange-box Midamox protect small to medium cats against each month?

Ans: Each monthly application of Midamox for cats 5.1–9 lbs addresses heartworm disease, fleas, ear mites, roundworms, and hookworms all at once. Your vet can help you understand which of these parasites pose the greatest threat given where you live and how much time your cat spends outdoors.

Q2: Is the orange-box Midamox the right choice for treating ferrets as well?

Ans: Among all the Midamox for Cats applicator sizes, the orange box is the only one carrying FDA approval for use in ferrets. It covers heartworm prevention and flea treatment in ferrets tipping the scales at 2 lbs or more. Breeding, pregnant, or nursing ferrets fall outside the established safety profile, so a vet check is essential first.

Q3: Why is heartworm prevention more urgent for cats than for dogs?

Ans: A cat's body is not a natural host for heartworms, which means even one or two worms can put a cat's life at serious risk. Signs of infection in cats are often quiet and easy to overlook. Unlike dogs, cats have no approved treatment path once infected, making monthly prevention the only reliable safeguard available.

Q4: Do indoor cats really need monthly parasite protection like Midamox?

Ans: Staying indoors does not make a cat immune to parasites. Mosquitoes that carry heartworm larvae can find their way inside through open windows and doors, and fleas often enter on shoes or clothing. Given how serious heartworm disease is in cats, most vets recommend year-round monthly protection regardless of indoor or outdoor lifestyle.

Q5: How does Midamox orange box compare to Advantage Multi for Cats?

Ans: The two products are FDA-confirmed bioequivalents, built around the same active ingredients at matching concentrations and tested to deliver the same clinical results. Cat owners who switch from Advantage Multi to Midamox can expect the same monthly parasite coverage, often at a noticeably lower cost per dose.

Clinical Research

Heartworm Disease in Cats – American Heartworm Society

Moxidectin – ScienceDirect Topics

Imidacloprid in Cats – VCA Animal Hospitals

Fleas in Cats – MSD Veterinary Manual