Midamox Topical Solution for Dogs, 3-9 lbs, Green Box

Monthly Parasite Spot-On Protection for Small Breed Dogs

Product Description

Midamox Topical Solution for Dogs 3–9 lbs is an FDA-approved prescription monthly spot-on parasiticide for dogs and puppies seven weeks and older within this weight range. Each green-box carton holds six single-dose applicators, giving small and toy breed owners a six-month supply. The formulation combines imidacloprid and moxidectin to cover heartworm disease, flea infestations, sarcoptic mange, intestinal worms, and circulating microfilariae in a single monthly application. It is bioequivalent to Advantage Multi for Dogs.

Benefits

• Prevents Heartworm Disease: Keeps small and toy breed dogs protected against Dirofilaria immitis heartworm infection when applied faithfully on a monthly basis.
• Kills Fleas and Tackles Infestations: Rapidly wipes out adult fleas on the dog and helps bring active flea infestations in the home under control with each application.
• Treats Sarcoptic Mange: Addresses sarcoptic mange caused by Sarcoptes scabiei var. canis in small dogs, bringing relief from the intense itching and skin damage this mite causes.
• Covers Intestinal Worms: Takes care of hookworm, roundworm, and whipworm infections internally, giving small dogs both external and internal parasite coverage in one product.
• Treats Circulating Microfilariae: The only FDA-approved active ingredient combination for treating heartworm microfilariae in confirmed heartworm-positive dogs, under close veterinary supervision.
• Six-Month Supply Per Box: Each green-box carton contains six applicators, covering a full six months of parasite protection for small and toy breed dogs.

Ingredients

Active Ingredients

Imidacloprid 10%, Moxidectin 2.5% per applicator

How to Use

Midamox Topical Solution for Dogs 3–9 lbs is a prescription-only medication. A valid prescription from a licensed veterinarian is required to purchase this medicine.

Please follow your veterinarian's specific instructions for dosage, frequency, and administration of this medication for your dog.

Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.

Additional Information

Precautions

• Minimum Age and Weight: Only use on dogs and puppies that are at least seven weeks old and weigh a minimum of three pounds at the time of application.
• Apply Between Shoulder Blades: For dogs in this weight range, the full contents of the applicator go onto a single spot between the shoulder blades on the back.
• Prevent Licking After Application: Stop the treated dog from licking the application site on themselves or any other treated animal for at least 30 minutes after applying.
• Never Apply to Cats: Moxidectin levels in this dog formulation far exceed what cats can safely handle and can prove fatal if applied to them.
• Caution in Unwell Dogs: Sick, debilitated, or underweight dogs carry a higher risk of adverse reactions and should only receive this product under direct veterinary guidance.
• Avoid in Breeding or Pregnant Dogs: Safety has not been confirmed in breeding, pregnant, or lactating dogs; only use in these animals if a vet has specifically approved it.
• MDR1-Affected Breeds: Collies and other breeds with the MDR1 gene mutation may have heightened sensitivity to moxidectin; speak to your vet before use in these breeds.

Possible Side Effects

• Diarrhea and Bloody Stools: Gut-related effects including loose stools or bloody stools have been reported, and may be more likely in dogs carrying a heavy parasite burden at the time of treatment.
• Lethargy and Reduced Appetite: Some small dogs show lower energy levels and less interest in food following their monthly application of this product.
• Respiratory and Eye Discharge: Coughing, nasal discharge, and eye discharge have been noted particularly in heartworm-positive dogs receiving microfilariae treatment.
• Hair Changes at Application Site: The fur at the treated spot may look stiff or oily for a short while after application, but this clears up on its own within about 48 hours.
• Serious Neurological Signs: Tremors, loss of coordination, or seizures are uncommon but require emergency veterinary attention the moment they are noticed.

Storage Information

• Room Temperature Storage: Tuck applicators away from heat and direct light in a consistently cool spot to keep them in good condition until use.
• Keep Sealed Until Use: Leave each applicator inside its foil pouch right up until the moment of monthly application to protect potency and prevent contamination.
• Keep Out of Reach: Store in a location that children and untreated animals in the household simply cannot get into at any point.

NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What parasites does the green-box Midamox cover in small dogs?

Ans: Midamox for dogs 3–9 lbs addresses heartworm disease, adult fleas and flea infestations, sarcoptic mange, hookworms, roundworms, and whipworms all in one monthly application. Your vet will help work out which of these parasites are most relevant based on your dog's lifestyle, environment, and geographic location.

Q2: Why is heartworm prevention especially important for small and toy breed dogs?

Ans: Small dogs have less physical capacity in their heart and blood vessels, meaning even a modest worm burden can create serious problems faster than it would in a larger dog. Starting monthly prevention from seven weeks of age is the most reliable way to keep toy and small breeds safe from a disease that is far easier to prevent than it is to manage once established.

Q3: Can Midamox green-box be used alongside other medications my small dog is taking?

Ans: Field safety studies showed this product used safely alongside a broad range of common medications including anticonvulsants, corticosteroids, NSAIDs, antihistamines, and thyroid hormones. That said, always give your vet a full picture of everything your dog is currently taking before starting Midamox, as individual situations can vary.

Q4: Should a small dog be tested for heartworm before starting Midamox?

Ans: Yes, a heartworm test before starting any monthly preventive is strongly recommended. Beginning Midamox in a dog that already carries an adult heartworm infection will not clear those worms and can trigger adverse reactions as microfilariae are eliminated. Your vet will map out the right course of action if a positive result comes back.

Q5: Is Midamox green-box the same as Advantage Multi for Dogs in small breed size?

Ans: Midamox is FDA-confirmed bioequivalent to Advantage Multi for Dogs, built on the same active ingredients at matching concentrations. Small breed owners who switch can count on the same broad monthly parasite coverage, often at a noticeably lower cost per dose than the branded alternative.

Clinical Research

FDA – Heartworm Disease in Dogs

CDC – Parasites in Dogs

PetMD – Flea & Tick Treatments