NexGard COMBO Topical for Cats 5.6–16.5 lbs
All-in-One Parasite Protection
NexGard COMBO Topical for Cats 5.6–16.5 lbs is a veterinarian-recommended, broad-spectrum topical solution formulated specifically for felines within the 5.6–16.5 lbs weight range. This powerful monthly treatment delivers triple-action protection against fleas, ticks, ear mites, roundworms, hookworms, and tapeworms, ensuring your cat remains parasite-free from head to tail.
Designed for ease and efficacy, NexGard COMBO combines esafoxolaner, eprinomectin, and praziquantel, three clinically-proven ingredients that target internal and external parasites. Whether your cat is an indoor companion or an adventurous outdoor explorer, this advanced formula ensures complete parasitic coverage with just one easy-to-apply dose per month.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.
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What Are the Key Benefits of NexGard COMBO Topical for Cats?
NexGard COMBO stands out due to its comprehensive parasite control and single-application convenience. Here’s what makes it superior to traditional flea or dewormer treatments:
- Triple-active formulation protects against both internal and external parasites
- Kills fleas (Ctenocephalides felis) within 6 hours and prevents reinfestation
- Eliminates common ticks like the black-legged tick (Ixodes scapularis), Gulf Coast tick (Amblyomma maculatum), and American dog tick (Dermacentor variabilis)
- Treats and controls roundworms, hookworms, and tapeworms
- Also kills ear mites, a common cause of feline ear infections
- Fast-drying, waterproof formula ideal for active or outdoor cats
- Vet-approved and FDA-approved for safe monthly use in cats 8 weeks and older

Subscription and Purchase Information
Buying Options and Discounts: Purchase NexGard Combo Topical for Cats (Yellow Box) in a convenient 1, 2, 3, and 6-month supply pack. Subscribe for regular shipments to ensure you never miss a dose and enjoy discounts on your purchases.
Order online for hassle-free delivery to your doorstep.
Who Should Use NexGard COMBO for Cats?
This product is ideal for:
- Indoor cats: who may still be exposed to fleas, mites, or infected rodents.
- Outdoor or indoor-outdoor cats: more prone to tick and worm infestations.
- Rescue or shelter cats: who may have unknown parasitic exposures.
- Multi-pet households: seeking streamlined, broad protection for feline companions.
How to Apply NexGard COMBO for Cats 5.6–16.5 lbs?
Follow these easy steps to ensure safe and effective application:
- Remove one pipette from the packaging.
- Hold your cat in a standing position or gently restrain.
- Part the hair on the back of the neck (at the base of the skull).
- Place the tip of the applicator on the skin and squeeze the entire contents in one spot.
- Allow the area to dry; do not rub in or bathe your cat for 48 hours post-application.
Tips to Maximize Effectiveness of NexGard COMBO
- Apply on dry skin and avoid bathing your cat for 48 hours post-application.
- Use monthly without gaps to ensure continuous protection.
- Keep cats separated briefly after treatment to avoid ingestion during grooming.
- Clean pet bedding and vacuum frequently to reduce environmental infestations.
What Are the Active Ingredients in NexGard COMBO and How Do They Work?
Each 0.9 mL dose of NexGard COMBO contains:
|
Ingredient |
Function |
|
Esafoxolaner |
Kills fleas and ticks by disrupting their nervous system |
|
Eprinomectin |
Paralyzes and kills intestinal parasites like roundworms and hookworms |
|
Praziquantel |
Effectively eliminates tapeworms |
Esafoxolaner is an isoxazoline compound targeting the GABA-gated chloride channels in ectoparasites, leading to paralysis and death of the parasites.
Are There Any Side Effects of NexGard COMBO for Cats?
Most cats tolerate NexGard COMBO well. However, potential side effects may include:
- Temporary hair loss or redness at the application site
- Vomiting, lethargy, or drooling in sensitive cats
- Neurological reactions (rare), such as tremors or incoordination
If adverse symptoms persist or worsen, consult your veterinarian immediately.
What Warnings Should Cat Owners Know Before Using This Product?
- For topical use only. Do not ingest or allow contact with your cat’s eyes or mouth.
- Safe for kittens 8 weeks and older and weighing at least 1.8 lbs
- Avoid use in cats with a history of seizures unless advised by a vet
- Wash hands after application
- Do not allow children or other pets to contact the treated area until dry
Shipping & Returns
Shipping Policy: HardyPaw offer all types of shipping options (Ground, Express, Priority, International) depending on the urgency of the product requirements. To know about our shipping policy in detail, click here.
Refund policy: If you face any issue with our product and want to return it, read our refund policy carefully.
FAQs About NexGard COMBO for Cats 5.6–16.5 lbs
What is NexGard COMBO used for in cats?
NexGard COMBO is used to protect cats against fleas, ticks, intestinal worms, and ear mites. It provides monthly topical protection for both internal and external parasites.
How fast does NexGard COMBO kill fleas and ticks?
NexGard COMBO begins killing fleas within 6 hours and ticks within 24 hours of application, offering fast-acting relief and prevention.
Can NexGard COMBO be used with other medications?
Yes, but always consult your vet before combining treatments. NexGard COMBO has shown compatibility with many common veterinary medications.
How long does one dose of NexGard COMBO last?
Each dose provides 30 days of comprehensive protection. Reapply monthly for continuous coverage.
Is NexGard COMBO safe for pregnant or nursing cats?
The safety of NexGard COMBO in breeding, pregnant, or lactating cats has not been established. Consult a veterinarian before use in such cases.
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