Norfenicol (Florfenicol) Solution for Beef & Non-Lactating Dairy Cattle

Florfenicol Antibiotic Injection for Cattle Respiratory and Foot Infections

Product Description

Norfenicol (Florfenicol) Injectable Solution 300 mg/mL is an FDA-approved prescription broad-spectrum antibiotic for IM and SC use in beef and non-lactating dairy cattle only. Each mL has 300 mg florfenicol, 250 mg 2-pyrrolidone, and glycerol formal. It treats and controls bovine respiratory disease (BRD) and foot rot in cattle, and comes in three vial sizes to suit different herd sizes and treatment volumes.

Benefits

• BRD Treatment: Tackles bovine respiratory disease in cattle by targeting the three key bacterial pathogens behind most BRD outbreaks.
• BRD Prevention: Keeps respiratory disease from taking hold in cattle already at high risk from the same three target pathogens.
• Foot Rot Treatment: Clears bovine interdigital phlegmon (foot rot) caused by Fusobacterium necrophorum and Bacteroides melaninogenicus in cattle.
• Dual Administration Routes: Given as two IM doses 48 hours apart or as one SC injection in the neck, depending on the protocol chosen.
• Fast Clinical Response: Most treated cattle begin showing clear clinical improvement within 24 hours of the first dose being given.
• Bactericidal Activity: Florfenicol kills Mannheimia haemolytica and Histophilus somni isolates directly rather than just slowing their growth.

Ingredients

Active Ingredients

Florfenicol: 300 mg per mL

Inactive Ingredients

2-pyrrolidone 250 mg/mL, glycerol formal qs

How to Use

Dosage and Administration Instructions

• Prescription Required: Federal law restricts Norfenicol to use by or on the order of a licensed veterinarian only.
• IM Dose: Give 20 mg/kg (3 mL/100 lbs) intramuscularly, then repeat the same dose 48 hours after the first injection.
• SC Dose: Give one 40 mg/kg (6 mL/100 lbs) subcutaneous injection in the neck as a single-dose alternative to IM dosing.
• SC BRD Control: For high-risk cattle, give a single 40 mg/kg (6 mL/100 lbs) SC neck injection to control BRD before it develops.
• Neck Injection Only: Always inject in the neck only as tissue reactions elsewhere on the body tend to be significantly more severe.
• 10 mL Per Site: Never give more than 10 mL at any one injection site regardless of whether the IM or SC route is being used.
• Re-evaluate at 72 Hours: If the animal shows no clear improvement within 72 hours of starting, revisit the diagnosis right away.
• Use Within 28 Days: Throw out any unused solution 28 days after the vial was first opened to keep it sterile and safe.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Cattle Only: Cleared for IM and SC use in beef and non-lactating dairy cattle only; never give to any other animal species.
• Female Dairy Restriction: Not cleared for female dairy cattle 20 months or older, including dry cows, due to the risk of milk residues.
• Not for Veal Calves: Never use in calves destined for veal processing as no withdrawal period has been set for pre-ruminating calves.
• Not for Breeding Animals: The impact of florfenicol on reproductive performance, pregnancy, and lactation in cattle has not been studied.
• Testicular Degeneration Risk: Animal toxicity studies have linked florfenicol to testicular degeneration and atrophy in dogs, rats, and mice.
• IM Withdrawal Period: Cattle must not go to slaughter for human consumption within 28 days of the last intramuscular dose given.
• SC Withdrawal Period: Cattle treated subcutaneously must stay out of the human food supply for at least 33 days after treatment.
• Hypersensitivity Contraindication: Never give to any animal that has had a prior allergic or hypersensitivity reaction to florfenicol.
• Human Safety: Keep off skin, eyes, and clothes; flush eyes for 15 minutes and wash skin with soap and water if any contact happens.

Possible Side Effects

• Reduced Appetite: Some cattle may eat and drink less than usual in the days following Norfenicol treatment; this is generally temporary.
• Loose Stools: Brief episodes of diarrhea have been reported in cattle after both IM and SC administration of this product.
• Injection Site Reaction: IM injection can cause local tissue damage that lasts past 28 days and may mean losing some edible tissue at slaughter.
• Anaphylaxis Risk: Collapse and anaphylaxis have been reported with florfenicol products after approval; watch cattle closely after each dose.

Storage Information

• Store Below 25°C: No refrigeration needed; brief periods up to 30°C (86°F) will not affect product quality or potency.
• Minimize Heat Exposure: Short exposure up to 40°C (104°F) may be tolerated but should be avoided to keep the product in good condition.
• 28-Day Use Window: Use within 28 days of first opening the vial; a light yellow to straw color in the solution is normal and not a sign of reduced potency.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What infections does Norfenicol florfenicol injection treat in cattle?

Ans: Norfenicol is a prescription florfenicol injection that goes after the bacterial pathogens behind two of the most common cattle infections: bovine respiratory disease and foot rot (bovine interdigital phlegmon) in beef and non-lactating dairy cattle, covering multiple susceptible organisms across both conditions.

Q2: What is the correct dose of Norfenicol cattle antibiotic injection?

Ans: For IM use, give 20 mg/kg (3 mL/100 lbs) twice, 48 hours apart. For SC use, one dose of 40 mg/kg (6 mL/100 lbs) is enough. Both routes require neck injection only, and no single site should receive more than 10 mL at once.

Q3: What is the withdrawal period for Norfenicol florfenicol solution in cattle?

Ans: Cattle given IM doses must stay out of the food supply for 28 days after the last treatment. The SC route requires a longer 33-day wait. Going beyond the approved dose level can stretch drug residue timelines further, so always stick to the label amounts.

Q4: Can Norfenicol cattle antibiotic be used in lactating dairy cows?

Ans: No, Norfenicol is not cleared for female dairy cattle 20 months or older, which includes dry cows. Using it in lactating or older dairy cows risks leaving drug residues in milk and in calves born to cows that received treatment during that period.

Q5: Is Norfenicol the same as Nuflor florfenicol injection for cattle?

Ans: Norfenicol and Nuflor work with the same active ingredient at the same strength, so cattle owners get identical bacterial coverage for respiratory disease and foot rot. Norfenicol is an FDA-approved generic with the ANADA 200-591 approval number, making it a budget-friendly route to the same treatment outcome.