Nuflor (Florfenicol) Injectable Solution for Cattle

Original FDA-Approved Broad-Spectrum Florfenicol Antibiotic for Cattle

Product Description

Nuflor (Florfenicol) Injectable Solution 300 mg/mL is the original FDA-approved prescription broad-spectrum antibiotic for IM and SC use in beef and non-lactating dairy cattle only. Each mL has 300 mg florfenicol, 250 mg NMP, 150 mg propylene glycol, and polyethylene glycol. It treats and controls BRD and foot rot in cattle with no milk or meat withdrawal, available in 100 mL, 250 mL, and 500 mL glass vials.

Benefits

• BRD Treatment: Tackles bovine respiratory disease linked to Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in cattle.
• BRD Prevention: Keeps respiratory disease from developing in high-risk cattle already exposed to the same three BRD-causing pathogens.
• Foot Rot Treatment: Clears bovine interdigital phlegmon caused by Fusobacterium necrophorum and Bacteroides melaninogenicus in beef and dairy cattle.
• Dual Administration Routes: Administered by IM injection (two doses 48 hours apart) or a single SC injection in the neck.
• Bactericidal Activity: Kills Mannheimia haemolytica and Histophilus somni isolates directly rather than just slowing their growth in cattle.
• Fast Clinical Response: Most treated cattle begin showing clear signs of improvement within 24 hours of the first dose being given.
• No Milk Discard: No milk discard and no preslaughter waiting period when this product is used exactly as the label directs.

Variants

Nuflor Injectable Solution 100 mL (300mg/ml)

Nuflor Injectable Solution 250 mL (300mg/ml)

Nuflor Injectable Solution 500 mL (300mg/ml)

Ingredients

Active Ingredients

Florfenicol: 300 mg per mL

Inactive Ingredients

N-methyl-2-pyrrolidone (NMP) 250 mg/mL, propylene glycol 150 mg/mL, polyethylene glycol qs

How to Use

Dosage and Administration Instructions

• Prescription Required: Federal law restricts Nuflor to use by or on the order of a licensed veterinarian only.
• IM Dose: Give 20 mg/kg (3 mL/100 lbs) intramuscularly in the neck and repeat the same dose 48 hours later.
• SC Dose: Give one 40 mg/kg (6 mL/100 lbs) subcutaneous neck injection as a single-dose alternative to IM dosing.
• SC BRD Control: For high-risk cattle, give a single 40 mg/kg (6 mL/100 lbs) SC neck injection to control BRD before it develops.
• Neck Injection Only: Always inject in the neck only as tissue reactions elsewhere on the body tend to be significantly more severe.
• 10 mL Per Site: Never give more than 10 mL at any one injection site regardless of whether the IM or SC route is being used.
• Re-evaluate at 72 Hours: If the animal shows no clear improvement within 72 hours of starting, revisit the diagnosis right away.
• Stopper Puncture Limit: The 100 mL vial stopper caps out at 3 punctures; both the 250 mL and 500 mL stoppers allow up to 17.
• Use Within 30 Days: Throw out any unused solution 30 days after the vial was first opened to keep it sterile and safe.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Cattle Only: Cleared for IM and SC use in beef and non-lactating dairy cattle only; never give to any other animal species.
• Female Dairy Restriction: Not cleared for female dairy cattle 20 months or older, including dry cows, due to the risk of milk residues.
• Not for Veal Calves: Never use in calves destined for veal as no withdrawal period has been set for pre-ruminating calves.
• Not for Breeding Animals: The impact of florfenicol on reproductive performance, pregnancy, and lactation in cattle has not been studied.
• Testicular Degeneration Risk: Animal toxicity studies have linked florfenicol to testicular degeneration and atrophy in dogs, rats, and mice.
• IM Slaughter Withdrawal: Cattle must not go to slaughter for human consumption within 28 days of the last intramuscular dose.
• SC Slaughter Withdrawal: Cattle treated subcutaneously must stay out of the food supply for at least 38 days after treatment.
• Hypersensitivity Contraindication: Never give to any animal that has had a prior allergic reaction to florfenicol.
• NMP Pregnancy Warning: Pregnant women must wear gloves and avoid contact with Nuflor as NMP has shown reproductive toxicity in repeated animal studies.
• Skin and Eye Irritant: Keep off skin, eyes, and clothes; flush eyes for 15 minutes and wash skin with soap if any contact occurs.

Possible Side Effects

• Reduced Appetite: Some cattle may eat and drink less than usual in the days following Nuflor treatment; this is generally temporary.
• Loose Stools: Brief diarrhea has been reported in cattle after both IM and SC administration at the recommended dose.
• Injection Site Reaction: IM injection can cause local tissue damage lasting past 28 days and may mean losing some edible tissue at slaughter.

Storage Information

• Store Between 2-30°C: No refrigeration needed; keep away from light when not in use to protect product stability.
• Use Within 30 Days: Throw out unused solution 30 days after first opening; never exceed the puncture limit for each vial size.
• Keep Out of Reach: Store in a locked spot away from children and animals to prevent any accidental contact or ingestion.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What infections does Nuflor florfenicol injection treat in cattle?

Ans: Nuflor treats bovine respiratory disease (BRD) caused by Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni, and bovine interdigital phlegmon (foot rot) caused by Fusobacterium necrophorum and Bacteroides melaninogenicus. It also controls BRD in beef and non-lactating dairy cattle at high risk of developing these infections.

Q2: What is the correct Nuflor cattle antibiotic dose and route of administration?

Ans: For IM use, give 20 mg/kg (3 mL/100 lbs) twice, 48 hours apart, in the neck only. For SC use, give a single dose of 40 mg/kg (6 mL/100 lbs) in the neck only. Do not exceed 10 mL per injection site for either route.

Q3: What are the withdrawal periods for Nuflor florfenicol in beef and dairy cattle?

Ans: Cattle treated by IM injection must not be slaughtered for human consumption within 28 days of the last treatment. For SC treatment, the preslaughter withdrawal period is 38 days. No milk discard period applies when the product is used as directed.

Q4: What are the stopper puncture limits for the different Nuflor vial sizes?

Ans: The 100 mL vial stopper tops out at 3 punctures while both the 250 mL and 500 mL stoppers can handle up to 17. All three sizes need to be used up within 30 days of first being opened, no matter how many times the stopper has been entered.

Q5: How does Nuflor florfenicol solution differ from Norfenicol for cattle?

Ans: Both share the same 300 mg/mL florfenicol strength and cover the same conditions. Nuflor uses NMP, propylene glycol, and PEG as inactive ingredients while Norfenicol uses 2-pyrrolidone and glycerol formal. The SC withdrawal period is also longer for Nuflor at 38 days versus 33 days for Norfenicol, and Nuflor is the original brand under NADA 141-063.