Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Product title
Vendor
$19.99 | $24.99
Injectable Antiemetic to Prevent and Treat Severe Vomiting in Pets
Product Description
Ondansetron HCl Injection 2mg/mL is a prescription antiemetic used by veterinarians for dogs and cats experiencing severe vomiting and nausea. It works by latching onto 5HT3 serotonin receptors on vagal nerve terminals and enteric neurons in the gastrointestinal tract, as well as in the brain's chemoreceptor trigger zone, shutting down the vomiting reflex at multiple points simultaneously. It is particularly effective for chemotherapy-induced vomiting, post-operative nausea, and serious gastrointestinal illness, and is used off-label in veterinary medicine.
Benefits
- Chemotherapy Vomiting Control: Works well at preventing and bringing down vomiting episodes tied to cancer chemotherapy treatment in dogs and cats.
- Dual-Site Mechanism: Takes on serotonin receptors in both the gastrointestinal tract and the brain's chemoreceptor trigger zone for thorough vomiting control.
- Post-Operative Nausea Relief: Given after surgery to keep nausea and vomiting under control during recovery in dogs and cats.
- Parvoviral Enteritis Support: Performs as well as metoclopramide and maropitant in bringing vomiting frequency down in dogs with parvoviral enteritis.
- Fast-Acting Injectable Delivery: The injectable route gets the antiemetic effect going reliably within one to two hours of administration.
Ingredients
Active Ingredients
Ondansetron Hydrochloride 2mg/mL
Other Ingredients
Sodium citrate, citric acid monohydrate, water for injection
How to Use
Ondansetron HCl Injection 2mg/mL is a prescription-only medication. A valid veterinarian prescription is required to purchase this product.
Please follow your veterinarian's specific instructions for the dosage and administration of this medication for your pet.
Disclaimer: Dosage and administration of this medication must be determined by a licensed veterinarian. Always consult your veterinarian before administering or adjusting any prescription medication for your pet.
Additional Information
Precautions
- Known Allergy Contraindication: Pets with a known sensitivity or allergy to ondansetron or related 5HT3 receptor antagonist medications should not receive this medication.
- Caution in Liver Disease: Reduced liver function slows how ondansetron is broken down, which can allow the drug to build up and raise the risk of side effects.
- Caution in Cardiac Conditions: Pets with known cardiac arrhythmias or those on medications that affect heart rhythm need careful management before starting this medication.
- Caution in Pregnancy: How this medication affects pregnant or nursing animals is not fully established, so a veterinarian should review the situation before use.
- Inspect Before Use: Check the vial before every use and set it aside if the solution looks hazy, off in color, or has anything visible floating in it.
- Drug Interaction Risk: Share a full list of your pet's current medications, particularly any serotonergic drugs, with your veterinarian before starting ondansetron.
Possible Side Effects
- Sedation and Lethargy: Some drowsiness and lower energy can show up in dogs and cats following ondansetron administration and are worth monitoring.
- Constipation or Diarrhea: Shifts in bowel habits, whether toward constipation or loose stools, can come up and should be kept an eye on throughout treatment.
- Extrapyramidal Signs: Head shaking and involuntary movements, known as extrapyramidal signs, are an uncommon but noted reaction in some pets on this medication.
- Cardiac Arrhythmias: Arrhythmias and low blood pressure are rare but serious reactions that need immediate veterinary attention if they show up during treatment.
Storage Information
- Controlled Room Temperature: Store vials somewhere cool and dry, maintaining a temperature of 68°F to 77°F and keeping them away from heat and temperature extremes.
- Protect From Light: Keeping the vials away from direct sunlight helps the solution hold its potency and stay stable throughout its shelf life.
- Out of Reach: Keep this medication somewhere children and untreated animals in the home cannot get to it.
NOTE: For generic medications, the product image shown may not reflect the actual item received. Generic medications can vary in size, color, and shape between orders depending on the manufacturer. Additionally, your medication may arrive packaged in a HardyPaw Pharmacy vial.
Shipping & Return
We offer ground, express, and priority delivery; see our shipping policy for details.
For return instructions or product concerns, please refer to our detailed refund policy.
Prescription items are NON-RETURNABLE and NON-REFUNDABLE.
Frequently Asked Questions
Q1: What conditions does ondansetron injection treat in dogs and cats?
Ans: Ondansetron injection covers severe vomiting from chemotherapy, post-operative recovery, parvoviral enteritis, and serious gastrointestinal illness in dogs and cats. It may also be used in some pets for pruritus and sleep apnea. A veterinarian will assess whether ondansetron is the right antiemetic choice for the specific condition being treated.
Q2: How does ondansetron work differently from other antiemetics like metoclopramide?
Ans: Where metoclopramide primarily works as a dopamine antagonist, ondansetron goes after 5HT3 serotonin receptors in the gut and the brain's chemoreceptor trigger zone through a completely different pathway. That distinction makes ondansetron particularly strong for chemotherapy-induced vomiting and equally effective as metoclopramide and maropitant for parvoviral enteritis in dogs.
Q3: Is ondansetron injection FDA-approved for use in dogs and cats?
Ans: Ondansetron only holds FDA approval for human use. Veterinarians are legally able to prescribe it for dogs and cats under extra-label use regulations, which cover situations where no approved veterinary alternative exists for a particular condition. A veterinarian will determine whether it is the right fit for a specific pet's needs.
Q4: Can ondansetron injection be given to cats undergoing chemotherapy?
Ans: Research has shown that giving ondansetron intramuscularly before procedures meaningfully reduced nausea and vomiting in cats, making it a well-supported option for managing chemotherapy-associated vomiting. A veterinarian will work out the right dose and timing as part of the cat's overall cancer treatment plan.
Q5: What signs indicate a serious reaction to ondansetron in pets?
Ans: Serious reactions are uncommon but can include cardiac arrhythmias, a significant drop in blood pressure, heavy sedation, involuntary head shaking or muscle movements, or allergic signs like facial swelling or collapse. Any of these showing up after administration should prompt an immediate call to a veterinarian or emergency clinic.