Ketoconazole is used to treat several fungal infections in dogs, cats and other small species. It is also used clinically for the medical treatment of hyperadrenocorticism in dogs. It can be used in palliative therapy in dogs with large, malignant, or invasive tumors and in whom surgery is not an option. It is used frequently in dogs for stabilization prior to surgery.
Possible Side Effects
Gastrointestinal signs of anorexia, vomiting, and/or diarrhea and weight loss are the most common adverse effects seen with ketoconazole therapy and are more prevalent in cats. Dividing the dose and/or giving it with meals may minimize gastrointestinal side effects. Appetite stimulants such as oxazepam or cyproheptadine may also be of benefit in cats.
Hepatic toxicity consisting of cholangiohepatitis and increased liver enzymes has been reported with ketoconazole, and may be either idiosyncratic in nature or a dose-related phenomenon. Cats may be more prone to developing hepatotoxicity than dogs. While liver enzymes should be monitored during therapy, an increase does not necessarily mandate dosage reduction or discontinuation unless concomitant anorexia, vomiting, diarrhea, or abdominal pain is present. Thrombocytopenia has also been reported with ketoconazole therapy, but is rarely encountered. A reversible lightening of haircoat may also occur in pets treated with ketoconazole. Cataracts in dogs, anecdotally attributed to ketoconazole therapy has been reported.
Ketoconazole has a transient dose-related suppressant effect on gonadal and adrenal steroid synthesis. Doses as low as 10 mg/kg depressed serum testosterone levels in dogs within 3-4 hours after dosing, but levels returned to normal within 10 hours. Doses of 30 mg/kg/day have been demonstrated to suppress serum cortisol levels in dogs with hyperadrenocorticism. Dogs undergoing high dose antifungal therapy may need additional glucocorticoid support during periods of acute stress.
use as directed by your veterinarian.
Store at temperatures between 68° - 77°F.
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NOTE: For generic medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Hardy Paw Pharmacy vial.