PromAce (acepromazine) 10mg/ml Injection, 50ml vial

Multi-Species Phenothiazine Injectable Tranquilizer and Preanesthetic for Dogs, Cats, and Horses

Product Description

PromAce (Acepromazine Maleate) Injectable Solution 10 mg/mL is an FDA-approved prescription phenothiazine neuroleptic for intravenous, intramuscular, or subcutaneous use in dogs, cats, and horses, supplied in a 50 mL multi-dose vial. Each mL contains 10 mg acepromazine maleate, 0.36% sodium citrate, 0.075% citric acid, 1% benzyl alcohol as preservative, and water for injection. It acts rapidly to produce sedation, muscular relaxation, and reduction in spontaneous activity through central nervous system depression, without a hypnotic effect. Indicated for tranquilization and as a preanesthetic agent across all three species. Unlike the tablet form, the injectable covers dogs, cats, and horses in a single formulation.

Benefits

• Three-Species Coverage: A single vial provides injectable tranquilization for dogs, cats, and horses — the only PromAce formulation approved across all three species.
• Three Administration Routes: Can be given IV, IM, or SC depending on the clinical situation and species, giving the veterinarian flexible delivery options at the point of care.
• Effective Equine Procedure Aid: Particularly useful in horses when combined with local anesthesia for firing, castration, neurectomy, skin tumor removal, ocular surgery, and cast application.
• Facilitates Loading and Transport in Horses: Helps manage fractious horses during examination, treatment, loading, and transportation where oral administration is not practical.
• Lowers Anesthetic Requirements Across Species: As a preanesthetic in dogs, cats, and horses, acepromazine reduces total general anesthetic dose needed and supports smoother induction.
• Rapid Onset Without Hypnosis: Acts quickly to calm and sedate without producing a hypnotic state, keeping the animal responsive throughout the procedure.
• 50 mL Multi-Dose Vial: The 50 mL format supports repeated veterinary clinic use across multiple patients, making it practical for practice inventory and large animal field work.

Ingredients

Active Ingredients

Acepromazine Maleate: 10 mg per mL

Inactive Ingredients

Sodium citrate 0.36%, citric acid 0.075%, benzyl alcohol 1% (preservative), water for injection

How to Use

Dosage and Administration Instructions

• Prescription Required: Federal law restricts PromAce Injectable to use by or on the order of a licensed veterinarian only.
• Individualize Every Dose: The dose should be tailored to the degree of tranquilization required; as a general rule, the mg/lb requirement decreases as the animal's body weight increases.
• Dog Dose (IV/IM/SC): Give 0.25 to 0.5 mg/lb of body weight; IV doses must be administered slowly with at least 15 minutes allowed for full effect to develop.
• Cat Dose (IV/IM/SC): Give 0.5 to 1 mg/lb of body weight; cats require a relatively higher dose per pound than dogs to achieve the same level of sedation.
• Horse Dose (IV/IM/SC): Give 2 to 4 mg per 100 lb of body weight; limit the dose to the minimum needed due to the risk of penile paralysis in male horses.
• IV Administration — Allow 15 Minutes: After IV injection across all species, wait a full 15 minutes before assessing full sedative effect or making any dose adjustments.
• Smaller Doses for Sensitive Patients: Reduce the dose and proceed with extra caution in animals under stress, cardiac disease, hypovolemia, or shock conditions.
• Additive CNS Effects Require Anesthetic Dose Reduction: When used as a preanesthetic, reduce the dose of general anesthetics accordingly as acepromazine potentiates CNS depression.

Disclaimer: This dosage information is provided by the manufacturer. Always consult your veterinarian before administering or adjusting any supplement for your pet.

Additional Information

Precautions

• Organophosphate Contraindication: Phenothiazines potentiate organophosphate toxicity; never use PromAce Injectable alongside organophosphate dewormers, ectoparasiticides, or flea collars in any species.
• Procaine Hydrochloride Contraindication: Do not use PromAce Injectable alongside procaine hydrochloride; acepromazine potentiates the activity of this local anesthetic.
• Epinephrine Contraindicated: Do not administer epinephrine to acepromazine-treated animals; the alpha-blockade caused by phenothiazines leads to a paradoxical, potentially fatal blood pressure drop.
• Penile Paralysis Risk in Male Horses: Acepromazine can cause irreversible paralysis of the retractor penis muscle in castrated and uncastrated male horses; use only the minimum dose needed and warn owners of this risk.
• Intracarotid Injection in Horses is Potentially Fatal: Accidental intracarotid injection in horses can cause clinical signs ranging from disorientation and convulsions through to death; exercise extreme care during equine IV administration.
• Not for Horses Intended for Human Consumption: Do not use PromAce Injectable in horses destined for the human food supply.
• No Reversal Agent Available: There is no pharmacological reversal agent for acepromazine across any species; all treated animals must be monitored throughout the full duration of sedation.
• Keep Out of Reach: Store in a secured location away from children and all animals to prevent any accidental access to this injectable CNS-active agent.

Possible Side Effects

• Prolonged CNS Depression or Motor Restlessness: Excessive doses or use in sensitive animals can cause prolonged depression or paradoxical motor restlessness instead of the intended calming effect.
• Idiosyncratic Behavioral Reactions in Dogs and Cats: Rare but serious reactions including aggression, biting or chewing, and nervousness have been reported following parenteral acepromazine administration.
• Penile Protrusion in Male Horses: Reversible protrusion of the penis is a normal clinical sign during equine acepromazine narcosis; however, irreversible retractor muscle paralysis, though rare, has been reported.
• Intracarotid Reaction in Horses: Signs from accidental intracarotid injection range from disorientation and convulsive seizures to death in horses; this underscores the importance of confirmed venous placement before equine IV injection.

Storage Information

• Controlled Room Temperature: Store at 20-25°C (68-77°F); excursions between 15-30°C (59-86°F) are permitted without affecting injectable solution stability or potency.
• Keep Out of Reach: Store in a locked, secure location away from children and all animals at all times.

Shipping & Return

We offer ground, express, and priority delivery; see our shipping policy for details.

For return instructions or product concerns, please refer to our detailed refund policy.

Prescription items are NON-RETURNABLE and NON-REFUNDABLE.

Frequently Asked Questions

Q1: What animals can PromAce injectable acepromazine be used in?

Ans: PromAce Injectable 10 mg/mL is FDA-approved for intravenous, intramuscular, or subcutaneous use in dogs, cats, and horses. Unlike the PromAce tablet form, which is approved for dogs only, the injectable solution covers all three species in a single 50 mL multi-dose vial formulation.

Q2: What are the correct doses of PromAce acepromazine injection for dogs, cats, and horses?

Ans: For dogs, give 0.25-0.5 mg/lb by IV, IM, or SC. For cats, give 0.5-1 mg/lb by IV, IM, or SC. For horses, give 2-4 mg per 100 lb by IV, IM, or SC. IV doses must be given slowly across all species, with a minimum 15-minute wait before assessing full effect. Dosages decrease per lb as body weight increases.

Q3: What is the penile paralysis risk in male horses given PromAce acepromazine injection?

Ans: Acepromazine can cause irreversible paralysis of the retractor penis muscle in both castrated and uncastrated male horses, which is distinct from the reversible penile protrusion expected during normal acepromazine narcosis. The two cannot be differentiated at the time of tranquilization; therefore, only the minimum dose needed for the desired effect should be used in male horses.

Q4: Why is intracarotid injection of PromAce so dangerous in horses?

Ans: Accidental intracarotid injection of acepromazine in horses can produce severe neurological reactions ranging from disorientation and convulsive seizures all the way through to death. This makes confirming proper venous placement critical before any equine intravenous injection; when there is any doubt about the injection site, the IM route is the safer alternative.

Q5: Why is the cat dose of PromAce injectable higher per pound than the dog dose?

Ans: Cats typically require a higher dose on a mg/lb basis (0.5–1 mg/lb) than dogs (0.25–0.5 mg/lb), due to species-related differences in drug metabolism and receptor sensitivity to phenothiazines. In general across species, the required mg/lb dose tends to decrease as body weight increases, meaning smaller cats often need a greater dose per pound compared with larger dogs.